Results 271 to 280 of about 51,913 (289)

Mitoxyperilysis: A Milestone Discovery in the Field of Cell Death

open access: yes
MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
Maochen Li, Yuhan Niu, Pengtao Jiao
wiley   +1 more source

Necroptosis in atherosclerosis

Clinica Chimica Acta, 2022
Atherosclerosis, a chronic inflammatory disease, is a leading cause of death worldwide. Vascular endothelial cells (VECs), vascular smooth muscle cells (VSMCs) and macrophages play extremely vital roles in the formation of atherosclerotic plaques and subsequent atherosclerosis.
Xiaofan, Zhang   +3 more
openaire   +2 more sources

Necroptosis pathways in tumorigenesis

Seminars in Cancer Biology, 2022
Necroptosis is a caspase-independent form of programmed cell death executed by the receptor interacting protein kinase 1 (RIPK1)-RIPK3-mixed lineage kinase domain-like protein (MLKL) signaling cascade, deregulation of which can cause various human diseases including cancer.
Tao, Zhang   +3 more
openaire   +2 more sources

Necroptosis at a glance

Journal of Cell Science, 2022
ABSTRACT Necroptosis, or programmed necrosis, is an inflammatory form of cell death with important functions in host defense against pathogens and tissue homeostasis. The four cytosolic receptor-interacting protein kinase homotypic interaction motif (RHIM)-containing adaptor proteins RIPK1, RIPK3, TRIF (also known as TICAM1) and ZBP1 ...
Kidong Kang   +2 more
openaire   +2 more sources

Necroptosis and tumor progression

Trends in Cancer, 2022
Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense against certain pathogen invasions. The deregulation of necroptosis is also a key factor of many inflammatory diseases. Recent studies have revealed an important role of necroptosis in tumorigenesis and metastasis and imply the potential of targeting necroptosis as a
Jiong, Yan   +3 more
openaire   +2 more sources

Necroptosis and Inflammation

Annual Review of Biochemistry, 2016
Necroptosis is a regulated form of necrosis, with the dying cell rupturing and releasing intracellular components that can trigger an innate immune response. Toll-like receptor 3 and 4 agonists, tumor necrosis factor, certain viral infections, or the T cell receptor can trigger necroptosis if the activity of the protease caspase-8 is compromised ...
Kim, Newton, Gerard, Manning
openaire   +2 more sources

Distinguishing Necroptosis from Apoptosis

2018
Apoptosis was the first programmed cell death to be defined-highly regulated and immunologically silent, as apoptotic bodies are being removed without triggering inflammation. Few decades later, necroptosis was discovered-uniquely regulated but inflammatory.
Inbar, Shlomovitz   +4 more
openaire   +2 more sources

Home - About - Disclaimer - Privacy