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Necrotizing autoimmune myopathy
Orvosi Hetilap, 2012Idiopathic inflammatory myopathies are systemic autoimmune diseases characterized by symmetrical proximal muscle weakness. One of them is the subgroup of necrotizing autoimmune myopathy, which has recently been recognized as a separate entity. In addition to the typical symmetrical muscle weakness, it is characterized by very high creatine kinase ...
Levente, Bodoki +6 more
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Necrotizing myopathy: Clinicoserologic associations
Muscle & Nerve, 2012AbstractIntroduction: Necrotizing myopathy (NM) is distinguished from idiopathic inflammatory myositis (IIM) by dominance of myofiber necrosis, lack of mononuclear inflammatory infiltrates, and presence of antibodies to signal recognition particle (SRP). Methods: The clinical features of 64 cases of NM were determined. Measurement of autoantibodies was
Ellis, E. +6 more
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Postinfectious Focal Necrotizing Myopathy
Clinical Nuclear Medicine, 2008A 37-year-old woman was admitted to our department with general fatigue, fever, and asymmetric pain in her lower legs, 2 weeks after a common cold. Dynamic skeletal scintigraphy with 780 MBq (20 mCi) Tc-99m HDP revealed increased perfusion and tracer uptake in the soft tissue of the lower legs, suggesting an inflammatory etiology.
Manuel, Dafotakis +5 more
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Scintigraphic Findings in Necrotizing Myopathy
Clinical Nuclear Medicine, 2003Necrotizing myopathy is a rare syndrome associated with several causes, including non-small-cell lung carcinoma. The authors present a case of this infrequently occurring disease, describe an unusual scintigraphic pattern, and show tracer uptake localized in soft tissues rather than the skeleton.
Christina, Nanni +7 more
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Acute Necrotizing Myopathy in a Dog
Journal of the American Animal Hospital Association, 2011A 9 yr old spayed female cocker spaniel presented for an acute onset of weakness. Rhabdomyolysis and myoglobinuria were found 36 hr after presentation. The dog was managed for several electrolyte and mineral abnormalities and rhabdomyolysis-induced acute renal failure.
Jill A, Willamson +2 more
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Immune-mediated necrotizing myopathy
Zeitschrift für Rheumatologie, 2016Immune-mediated necrotizing myopathy (IMNM) is a newly identified subgroup of idiopathic inflammatory myopathies. It is defined as a rare and severe disease, with symmetrical and proximal muscle weakness and a characteristic histology. An autoimmune aspect of IMNM is suggested by its association with autoantibodies directed against signal recognition ...
C, Bergua +6 more
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Paraneoplastic necrotizing myopathy
Neurology, 1998To characterize the clinical features and muscle pathology of paraneoplastic necrotizing myopathy.Paraneoplastic syndromes involving many levels of the nervous system are well described, but there are only rare case reports of a necrotizing myopathy associated with cancer.Case series.We identified four patients with paraneoplastic necrotizing myopathy ...
M I, Levin +3 more
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[Necrotizing autoimmune myopathies].
Revue neurologique, 2014Necrotizing autoimmune myopathies are included in the spectrum of inflammatory myopathies, together with polymyosis, dermatopolymyosis and inclusion body myositis, despite the characteristic feature of marked muscular necrosis without inflammatory infiltrates.
P, Petiot +4 more
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Statin-associated necrotizing autoimmune myopathy
Modern Rheumatology, 2013Necrotizing autoimmune myopathy (NAM) is a severe adverse effect of statins. We report a 66-year-old Caucasian female who had progressive proximal muscle weakness after treatment with statins. Results of a muscle biopsy showed necrotizing myopathy with minimal inflammatory cell infiltrate and increased major histocompatibility class I antigen ...
Geórgea Hermogenes, Fernandes +2 more
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Rhabdomyolysis, myoglobinuria, and necrotizing myopathies
Veterinary Clinics of North America: Small Animal Practice, 2004The clinical syndrome of rhabdomyolysis is composed of acute muscle necrosis with swollen painful muscles (myalgia), limb weakness or collapse, markedly elevated creatine kinase (CK) concentration, and dark ‘‘cocacola’’–colored urine (myoglobinuria).
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