Results 51 to 60 of about 39,640 (202)
ELECTROPHORESIS, EarlyView.Lentiviral vector purification using QA CIM monolith anion‐exchange chromatography was optimized via 96‐well and DOE, increasing recovery from 20% to 90%. The process achieved 3.3‐log host cell protein reduction, decreased particle impurities, and showed high binding capacity, supporting large‐scale manufacturing.
Luka Bevc +7 more
wiley +1 more source
Cells, 2020 A significant number of people living with HIV (PLWH) develop HIV-associated neurocognitive disorders (HAND) despite highly effective antiretroviral therapy (ART). Dysregulated macroautophagy (autophagy) is implicated in HAND pathogenesis.
Laura Cheney +5 more
doaj +1 more source
Intracellular overexpression of HIV-1 Nef impairs differentiation and maturation of monocytic precursors towards dendritic cells. [PDF]
PLoS ONE, 2012 Nef functions as an immunosuppressive factor critical for HIV-1 replication, survival and development of AIDS following HIV-1 infection. What effects Nef exerts on differentiation and maturation of monocytes towards dendritic cells (DCs) remains greatly ...
Yan Guo +5 more
doaj +1 more source
Rack1 Binds HIV-1 Nef and Can Act as a Nef–Protein Kinase C Adaptor [PDF]
, 2001 Nef proteins of primate immunodeficiency viruses exert pleiotropic effects, such as enhanced endocytosis of CD4 and MHC-I cell surface molecules, perturbation of signal transduction cascades, and virion infectivity enhancement.
Rossi, F., Milanesi, G., Gallina, A.
core +1 more source
International Studies of Economics, EarlyView.Abstract This paper examines the link between climate risk, energy consumption, and financial market performance in a sample of emerging countries over the period 2000–2024. The objective is to model the dynamic interactions between these three dimensions, in order to understand the extent to which energy dependence and exposure to climate risks ...
Abdelkader Mohamed Derbali
wiley +1 more source
HIV-1 Nef is released in extracellular vesicles derived from astrocytes: Evidence for Nef-mediated neurotoxicity [PDF]
, 2017 © The Author(s) 2017. Human immunodeficiency virus-Associated neurological disorders (HANDs) affect the majority of AIDS patients and are a significant problem among HIV-1-infected individuals who live longer because of combined anti-retroviral therapies.
Cicalese, S +5 more
core +1 more source
Public Administration and Development, EarlyView.ABSTRACT The lack of a common variable for comparison has been a major obstacle to the development of Comparative Public Administration (CPA). State autonomy enables an integrative contextualization approach, allowing both the analysis of contextual individual country experiences and the generation of generalized comparable knowledge.
Wilson Wong
wiley +1 more source
HIV-1 Nef Stabilizes the Association of Adaptor Protein Complexes with Membranes
, 2003 The maximal virulence of HIV-1 requires Nef, a virally encoded peripheral membrane protein. Nef binds to the adaptor protein (AP) complexes of coated vesicles, inducing an expansion of the endosomal compartment and altering the surface expression of ...
Douglas Hitchin +19 more
core +1 more source
Oxaziridines: Versatile Reagents in Modern Organic Synthesis
The Chemical Record, EarlyView.Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra +2 more
wiley +1 more source
Вопросы вирусологииIntroduction. Nef provides high level of HIV-1 replication due to synergy of its multiple functions and is an important factor in the pathogenesis of HIV infection. Nef is considered as a target for development of therapeutic agents.
Anna I. Kuznetsova +10 more
doaj +1 more source