PLoS ONE, 2011 Nef is a multifunctional HIV-1 protein that accelerates progression to AIDS, and enhances the infectivity of progeny viruses through a mechanism that is not yet understood.
Nopporn Chutiwitoonchai +9 more
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HIV-1 Nef inhibits Protease activity and its absence alters protein content of mature viral particles. [PDF]
PLoS ONE, 2014 Nef is an important player for viral infectivity and AIDS progression, but the mechanisms involved are not completely understood. It was previously demonstrated that Nef interacts with GagPol through p6*-Protease region.
Luiza M Mendonça +4 more
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HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanism. [PDF]
PLoS ONE, 2014 Human and Simian Immunodeficiency virus (HIV-1, HIV-2, and SIV) encode an accessory protein, Nef, which is a pathogenesis and virulence factor. Nef is a multivalent adapter that dysregulates the trafficking of many immune cell receptors, including ...
Prabha Chandrasekaran +5 more
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HIV-1 Nef Disrupts CD4 T Lymphocyte Polarity, Extravasation, and Homing to Lymph Nodes via Its Nef-Associated Kinase Complex Interface. [PDF]
, 2018 HIV-1 Nef is a multifunctional protein that optimizes virus spread and promotes immune evasion of infected cells to accelerate disease progression in AIDS patients.
Thoma, Judith +16 more
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, 2023 1899 gründete Karl Nef die Ortsgruppe Basel der Internationalen Gesellschaft für Musik. Nach der einseitigen Auflösung der I.G.M. durch den deutschen Landesverein, wurde die Ortsgruppe Basel zum einem Rückzugsort für die Vernetzung von ...
Urchueguía, Cristina
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Nef-containing exosomes deliver Nef to macrophages.
, 2019 A—Size distribution of the extracellular vesicles secreted by HEK293 cells determined by EM; Inset–EM micrograph of the vesicles; bar– 200 nm. B—Western blot for the exosomal marker Alix and Nef in cells and exosomes (exNef); C—Western blot for the ...
Ryunosuke Ohkawa (514009) +15 more
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Biology Direct, 2021 Background A variety of hematopoietic abnormalities are commonly seen in human immunodeficiency virus-1 (HIV-1) infected individuals despite antiviral therapy, but the underlying mechanism remains elusive.
Wei Zou +8 more
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Exploiting knowledge of immune selection in HIV-1 to detect HIV-specific CD8 T-cell responses [PDF]
, 2010 Since HLA-restricted cytotoxic T-cell responses select specific polymorphisms in HIV-1 sequences and HLA diversity is relatively static in human populations, we investigated the use of peptide epitopes based on sites of HLA-associated adaptation in HIV-1
McKinnon, E. +21 more
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HIV-1 Myristoylated Nef Treatment of Murine Microglial Cells Activates Inducible Nitric Oxide Synthase, NO2 Production and Neurotoxic Activity. [PDF]
PLoS ONE, 2015 The potential role of the human immunodeficiency virus-1 (HIV-1) accessory protein Nef in the pathogenesis of neuroAIDS is still poorly understood.
Giorgio Mangino +12 more
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A Highly Conserved Residue in HIV-1 Nef Alpha Helix 2 Modulates Protein Expression
mSphere, 2016 Extensive genetic diversity is a defining characteristic of human immunodeficiency virus type 1 (HIV-1) and poses a significant barrier to the development of an effective vaccine.
Aaron L. Johnson +6 more
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