Results 21 to 30 of about 39,640 (202)

S6_Data from Nef et al.

, 2022
S6 Data from the publication of Nef et al. in PLOS Biology entitled "Whole-genome scanning reveals environmental selection mechanisms that shape diversity in populations of the epipelagic diatom Chaetoceros".
Nef, Charlotte, Madoui, Mohammed-Amin, Pelletier, Éric, Bowler, Chris   +3 more
core   +1 more source

Exosomes are unlikely involved in intercellular Nef transfer. [PDF]

PLoS ONE, 2015
HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Several recent studies including ours have demonstrated that Nef can be transferred to neighboring cells and alters the function of these cells.
Xiaoyu Luo, Yan Fan, In-Woo Park, Johnny J He   +3 more
doaj   +1 more source

S10_S17_Data from Nef et al.

, 2022
Supplementary Data from the publication of Nef et al. in PLOS Biology entitled "Whole-genome scanning reveals environmental selection mechanisms that shape diversity in populations of the epipelagic diatom Chaetoceros". S10 Data.
Nef, Charlotte, Madoui, Mohammed-Amin, Pelletier, Éric, Bowler, Chris   +3 more
core   +1 more source

HIV-1 Nef Targets HDAC6 to Assure Viral Production and Virus Infection

Frontiers in Microbiology, 2019
HIV Nef is a central auxiliary protein in HIV infection and pathogenesis. Our results indicate that HDAC6 promotes the aggresome/autophagic degradation of the viral polyprotein Pr55Gag to inhibit HIV-1 production.
Sara Marrero-Hernández, Sara Marrero-Hernández, Daniel Márquez-Arce, Daniel Márquez-Arce, Romina Cabrera-Rodríguez, Romina Cabrera-Rodríguez, Judith Estévez-Herrera, Judith Estévez-Herrera, Silvia Pérez-Yanes, Silvia Pérez-Yanes, Jonathan Barroso-González, Ricardo Madrid, Ricardo Madrid, José-David Machado, Julià Blanco, Julià Blanco, Agustín Valenzuela-Fernández, Agustín Valenzuela-Fernández   +17 more
doaj   +1 more source

A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding. [PDF]

PLoS ONE, 2018
The HIV-1 Nef accessory protein is essential for viral pathogenicity and AIDS progression. Nef forms complexes with multiple host cell factors to facilitate viral replication and promote immune escape of HIV-infected cells.
Mousheng Wu, John J Alvarado, Corinne E Augelli-Szafran, Roger G Ptak, Thomas E Smithgall   +4 more
doaj   +1 more source

Flavin Catalysts in Organic Synthesis

Angewandte Chemie, EarlyView.
Flavins and their congeners are potent catalysts for organic synthesis inspired by enzymatic transformations. In addition to catalysis in the flavin ground state via covalent intermediates, the excited singlet and triplet states unlock applications including photooxidation, photoreduction, and energy transfer via sensitization.
Jan Freudenberg, Golo Storch
wiley   +2 more sources

S8_Data from Nef et al.

, 2022
S8 Data from the publication of Nef et al. in PLOS Biology entitled "Whole-genome scanning reveals environmental selection mechanisms that shape diversity in populations of the epipelagic diatom Chaetoceros". (A) Pairwise FST values of ARC_116.
Nef, Charlotte, Madoui, Mohammed-Amin, Pelletier, Éric, Bowler, Chris   +3 more
core   +1 more source

Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex

mBio, 2015
Human immunodeficiency virus type 1 (HIV-1) Nef enhances virus replication and contributes to immune evasion in vivo, but the underlying molecular mechanisms remain incompletely defined.
Andrea Imle, Libin Abraham, Nikolaos Tsopoulidis, Bernard Hoflack, Kalle Saksela, Oliver T. Fackler   +5 more
doaj   +1 more source

Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation

Retrovirology, 2012
Background HIV-1 Nef protein contributes to pathogenesis via multiple functions that include enhancement of viral replication and infectivity, alteration of intracellular trafficking, and modulation of cellular signaling pathways.
Mukerji Joya, Olivieri Kevin C, Misra Vikas, Agopian Kristin A, Gabuzda Dana   +4 more
doaj   +1 more source

Alkylating HIV-1 Nef - a potential way of HIV intervention

AIDS Research and Therapy, 2010
Background Nef is a 27 KDa HIV-1 accessory protein. It downregulates CD4 from infected cell surface, a mechanism critical for efficient viral replication and pathogenicity.
Cai Catherine, Zhang Xiaoping, Jin Yong-Jiu, Burakoff Steven J   +3 more
doaj   +1 more source