A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities. [PDF]
PLoS ONE, 2015 To find out new determinants required for Nef activity we performed a functional alanine scanning analysis along a discrete but highly conserved region at the core of HIV-1 Nef.
Marta Martínez-Bonet +7 more
doaj +3 more sources
A Critical History of Co-Production in the Design and Delivery of UK Mental Health Services. [PDF]
Health ExpectABSTRACT Background The term co‐production is now very common and risks losing its original egalitarian and emancipatory meaning. Questions about what the term means relate to how the concept developed historically. We conduct a critical history of the concept to shed some light on this and inform contemporary practice.
Fleischmann P, Schofield P.
europepmc +2 more sources
mBio, 2023 Human immunodeficiency virus type 1 (HIV-1) Nef hijacks the clathrin adaptor complex 2 (AP-2) to downregulate the viral receptor CD4 and the antiviral multipass transmembrane proteins SERINC3 and SERINC5, which inhibit the infectivity of progeny virions ...
Balaji Olety +4 more
doaj +1 more source
COVID-19: What Iodine Maps From Perfusion CT can reveal—A Prospective Cohort Study
Critical Care, 2020 Background Subtraction CT angiography (sCTA) is a technique used to evaluate pulmonary perfusion based on iodine distribution maps. The aim of this study is to assess lung perfusion changes with sCTA seen in patients with COVID-19 pneumonia and correlate
Mario G. Santamarina +6 more
doaj +1 more source
Expression, intracellular targeting and purification of HIV Nef variants in tobacco cells [PDF]
, 2007 Background Plants may represent excellent alternatives to classical heterologous protein expression systems, especially for the production of biopharmaceuticals and vaccine components.
Buriani, Giampaolo +23 more
core +1 more source
Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41. [PDF]
PLoS Pathogens, 2011 Primate lentivirus nef is required for sustained virus replication in vivo and accelerated progression to AIDS. While exploring the mechanism by which Nef increases the infectivity of cell-free virions, we investigated a functional link between Nef and ...
Rachel P J Lai +6 more
doaj +1 more source
Viruses, 2021 Nef is a multifunctional viral protein that has the ability to downregulate cell surface molecules, including CD4 and major histocompatibility complex class I (MHC-I) and, as recently shown, also members of the serine incorporator family (SERINC).
Zita Kruize +6 more
doaj +1 more source
Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity [PDF]
, 2013 G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome.
NADAI, MATTEO +36 more
core +2 more sources
A Long Cytoplasmic Loop Governs the Sensitivity of the Anti-viral Host Protein SERINC5 to HIV-1 Nef
Cell Reports, 2018 We recently identified the multipass transmembrane protein SERINC5 as an antiviral protein that can potently inhibit HIV-1 infectivity and is counteracted by HIV-1 Nef.
Weiwei Dai +3 more
doaj +1 more source
Proteomic profiling of SupT1 cells reveal modulation of host proteins by HIV-1 Nef variants. [PDF]
PLoS ONE, 2015 Nef is an accessory viral protein that promotes HIV-1 replication, facilitating alterations in cellular pathways via multiple protein-protein interactions.
Reshu Saxena +5 more
doaj +1 more source