A Long Cytoplasmic Loop Governs the Sensitivity of the Anti-viral Host Protein SERINC5 to HIV-1 Nef
Cell Reports, 2018 We recently identified the multipass transmembrane protein SERINC5 as an antiviral protein that can potently inhibit HIV-1 infectivity and is counteracted by HIV-1 Nef.
Weiwei Dai +3 more
doaj +1 more source
The Human Thioesterase II Protein Binds to a Site on HIV-1 Nef Critical for CD4 Down-regulation [PDF]
, 2000 A HIV-1 Nef affinity column was used to purify a 35-kDa Nef-interacting protein from T-cell lysates. The 35-kDa protein was identified by peptide microsequence analysis as the human thioesterase II (hTE) enzyme, an enzyme previously identified in a yeast
Baltimore, David +4 more
core +1 more source
mBio, 2023 Human immunodeficiency virus type 1 (HIV-1) Nef hijacks the clathrin adaptor complex 2 (AP-2) to downregulate the viral receptor CD4 and the antiviral multipass transmembrane proteins SERINC3 and SERINC5, which inhibit the infectivity of progeny virions ...
Balaji Olety +4 more
doaj +1 more source
COMPLEMENT-MEDIATED ADIPOCYTE LYSIS BY NEPHRITIC FACTOR SERA [PDF]
, 1993 Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway.
Lachmann, PJ +4 more
core +1 more source
HIV protein Nef expression in human microglia drives the release of distinct Nef-containing extracellular vesicles. [PDF]
Extracell Vesicles Circ Nucl AcidsLavrin T +13 more
europepmc +2 more sources
On nef and semistable hermitian lattices, and their behaviour under tensor product [PDF]
, 2010 We study the behaviour of semistability under tensor product in various settings: vector bundles, euclidean and hermitian lattices (alias Humbert forms or Arakelov bundles), multifiltered vector spaces.
André, Yves
core +2 more sources
Proteomic profiling of SupT1 cells reveal modulation of host proteins by HIV-1 Nef variants. [PDF]
PLoS ONE, 2015 Nef is an accessory viral protein that promotes HIV-1 replication, facilitating alterations in cellular pathways via multiple protein-protein interactions.
Reshu Saxena +5 more
doaj +1 more source
Asymptotic base loci on singular varieties [PDF]
, 2011 We prove that the non-nef locus and the restricted base locus of a pseudoeffective divisor coincide on KLT pairs. We also extend to KLT pairs F. Russo's characterization of nef and abundant divisors by means of asymptotic multiplier ideals.Comment ...
Di Biagio, Lorenzo, Salvatore Cacciola
core +1 more source
Le Narrenschiff de Sébastien Brant à l’épreuve du filtre foucaldien
Babel: Littératures Plurielles, 2012 Pour illustrer sa thèse historico-philosophique du partage entre une expérience cosmique et une expérience critique de la folie à l’aube de l’âge moderne, Michel Foucault mobilise au tout début de l’Histoire de la folie un ouvrage jusque là peu connu du ...
Jonas Kurscheidt
doaj +1 more source
Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity [PDF]
, 2013 G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome.
Frasson, Ilaria +8 more
core +2 more sources