Results 41 to 50 of about 41,389 (184)

A guide to heat shock factors as multifunctional transcriptional regulators

The FEBS Journal, Volume 292, Issue 16, Page 4133-4155, August 2025.
The heat shock factors (HSFs) are evolutionarily conserved transcription factors best known as regulators of molecular chaperone genes in response to heat shock and other protein‐damaging stresses. Vertebrate HSFs, HSF1‐5, HSFX, and HSFY, are implicated in various physiological and pathological processes, including organismal development and cancer ...
Hendrik S. E. Hästbacka, Alejandro J. Da Silva, Lea Sistonen, Eva Henriksson   +3 more
wiley   +1 more source

Characterization of the longitudinal HIV-1 quasispecies evolution in HIV-1 infected individuals co-infected with Mycobacterium tuberculosis [PDF]

, 2010
One of the earliest and most striking observations made about HIV is the extensive genetic variation that the virus has within individual hosts, particularly in the hypervariable regions of the env gene which is divided into 5 variable regions (V1-V5 ...
Leulebirhan, Tsigereda Biru
core  

Selective Activation of Src Family Kinases by the HIV-1 Nef Protein [PDF]

, 2006
Nef is a critical HIV-1 accessory factor shown to promote viral pathogenesis by altering host cell signaling pathways. Nef has been shown to bind several members of the Src family of protein-tyrosine kinases, and these interactions have been implicated ...
Trible, Ronald P
core   +1 more source

Natural variation of the nef gene in human immunodeficiency virus type 2 infections in Portugal [PDF]

, 2003
Human immunodeficiency virus type 2 (HIV-2) infections cause severe immunodeficiency in humans, although HIV-2 is associated frequently with reduced virulence and pathogenicity compared to HIV-1.
Almond, N., Berry, N., Bootman, J., Brown, S., Jenkins, A., Paixão, M.T., Pádua, E.   +6 more
core   +1 more source

Reactive Oxygen Species: From Tumorigenesis to Therapeutic Strategies in Cancer

Cancer Medicine, Volume 14, Issue 10, May 2025.
ABSTRACT Background Reactive oxygen species (ROS), a class of highly reactive molecules, are closely linked to the pathogenesis of various cancers. While ROS primarily originate from normal cellular processes, external stimuli can also contribute to their production. Cancer cells typically exhibit elevated ROS levels due to disrupted redox homeostasis,
Iqra Attique, Zahra Haider, Maha Khan, Samina Hassan, Mohamed Mohamed Soliman, Wisam Nabeel Ibrahim, Sumaira Anjum   +6 more
wiley   +1 more source

Cellular Viral Rebound after Cessation of Potent Antiretroviral Therapy Predicted by Levels of Multiply Spliced HIV-1 RNA Encoding nef [PDF]

, 2017
To characterize newly arising replication of human immunodeficiency virus (HIV) type 1 in vivo at the cellular level, distinct viral RNA species in peripheral blood mononuclear cells (PBMCs) from HIV-1-infected patients were monitored during 2 weeks of ...
Bleiber, Gabriela, Fischer, Marek, Günthard, Huldrych F., Hirschel, Bernard, Joos, Beda, Weber, Rainer   +5 more
core  

Oxidative Stress in People Living With HIV: Are Diverse Supplement Sources the Solution?

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aim Antiretroviral therapy (ART) has reduced human immunodeficiency virus (HIV)/AIDS to a manageable chronic condition even though no cure exists. Despite ART control, latent HIV infection results in failed memory CD4 T‐cell responses, immune overactivation, inflammation, oxidative stress, genomic instability, deoxyribonucleic ...
Esimebia Adjovi Amegashie, Ruth Oyawole Sikeola, Emmanuel Ayitey Tagoe, Elijah Paintsil, Kwasi Torpey, Osbourne Quaye   +5 more
wiley   +1 more source

Nef binds p6* in gagpol during replication of human immunodeficiency virus type 1

, 2004
The atypical Nef protein (NefF12) from human immunodeficiency virus type 1 strain F12 (HIV-1F12) interferes with virion production and infectivity via a mysterious mechanism.
Costa, Luciana J., Fackler, Oliver T., Mak, Johnson, Peterlin, B. Matija, Sabotic, Jerica, Zheng, Yong-Hui   +5 more
core   +2 more sources

Conserved presence of G-quadruplex forming sequences in the Long Terminal Repeat Promoter of Lentiviruses [PDF]

, 2017
G-quadruplexes (G4s) are secondary structures of nucleic acids that epigenetically regulate cellular processes. In the human immunodeficiency lentivirus 1 (HIV-1), dynamic G4s are located in the unique viral LTR promoter.
A Ayouba, A Henderson, A Rambaut, AK Todd, AM Fleming, AN Lane, AR Haeusler, B Berkhout, B Zhou, BF Keele, D Piekna-Przybylska, D Qu, D Rhodes, D Sen, DJ Patel, E Tosoni, EA Raiber, F Barre-Sinoussi, F Benachenhou, F Bibollet-Ruche, F Heuverswyn Van, F Turrini, G Biffi, GE Crooks, IT Holder, J Felsenstein, J Norseen, J Qiu, J Song, J Yamaguchi, JE Clements, JF Fisette, JP Taylor, K Tamura, K Tluckova, KA Jones, LA Pereira, M Fry, M Metifiot, M Sala, M Scalabrin, MA Larkin, N Maizels, ND Perkins, NH Campbell, P Fratta, P Ivanov, P Murat, P Sket, R Perrone, R Perrone, R Perrone, R Perrone, RC Edgar, RC Gallo, RJ Gifford, S Amrane, S Artusi, S Artusi, S Balasubramanian, S Bhatia, S Broos, S Burge, S Pohlmann, SE Tong-Starksen, SR Wang, SR Wang, Y Wang   +67 more
core   +1 more source

Genetic Evolution Between HIV‐1 Groups M and O: HIV‐1/MO Recombinant Forms

Journal of Medical Virology, Volume 97, Issue 5, May 2025.
ABSTRACT HIV exhibits significant genetic diversity, with genetic recombination being a major evolutionary process. The co‐circulation of HIV‐1/M and HIV‐1/O variants has led to the description of 20 HIV‐1/M+O dual infections since 1998. Despite the genetic divergence between these variants, HIV‐1/M+O dual infections have resulted in the emergence of ...
Alice Moisan, Fabienne Tombette, Jean‐Christophe Plantier   +2 more
wiley   +1 more source