Results 101 to 110 of about 23,293 (232)

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11143-11177, December 2026.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Study of Soil Microflora from Assam and NEFA

, 2014
This short note describes the fungi isolated from various soil samples of Assam and NEFA with special reference to the celluloytic types of fungal ...
Tandan, R. N., Nigam, S. S., Chatterji, M. G., Tandan, G. P.   +3 more
core   +1 more source

Aflatoxin B1 Exacerbates Ketogenic Diet‐Induced Hepatic Oxidative Stress and Glucose and Lipid Metabolic Disturbances in Mice

Food Frontiers, Volume 7, Issue 6, November 2026.
AFB1 exposure aggravates KD‐associated hepatic oxidative stress, inflammation, and glucose and lipid metabolic disturbances in mice. These effects are accompanied by dysregulation of AMPK, mTOR, and PPAR‐γ signaling and extensive hepatic metabolic reprogramming. ABSTRACT Aflatoxin B1 (AFB1) is a widespread mycotoxin with severe hepatotoxicity.
Xueyuan Hu, Zhenjun Sun, Xiaojing Wang, Shaochun Liu, ZhenBang Ye, Xueshu Han, Yang Ni, Linlin Hou, Yongping Chen, Huanqi Liu   +9 more
wiley   +1 more source

NEFA-species in rat liver and rat serum.

, 2014
A NEFA-species in rat liver homocysteine in rat serum; B NEFA-species in rat serum. The control group is shown as black bar, the fructose-fed group is shown as red bar and the FF treated group is shown as a blue bar; values given are means±s.d ...
Mark Broenstrup (627128), Tatiana Konovalova (548743), Hans-Ludwig Schaefer (627126), Gerd Schmitz (44452), Martin Troetzmueller (627127), Thomas Kopf (548745), Harald Koefeler (440003)   +6 more
core   +1 more source

Protecting CEACAM1 Expression Prevents Diet‐Induced Metabolic Dysfunction and Hepatic Fibrosis in Male Mice

Obesity, Volume 34, Issue 11, Page 2094-2108, November 2026.
ABSTRACT Objective High‐fat diet represses Ceacam1 transcription via a PPARα‐mediated mechanism to cause insulin resistance before inflammation develops. The current study investigated whether mutating PPRE‐RXRα in Ceacam1 promoter prevents diet‐induced metabolic abnormalities and hepatic fibrosis in male C57BL6/J mice.
Raziyeh Abdolahipour, Saja S. Khuder, William M. Philbrick, Agnes O. Portuphy, Getachew D. Belew, Hatem G. Fallouh, Harrison T. Muturi, Boyeon Kim, Jason K. Kim, Sonia M. Najjar   +9 more
wiley   +1 more source

Effects of exercise on plasma glucose, NEFA, glycerol and triglyceride levels from WT and IL-6^−/− mice.

, 2013
Values are means ±SE for 4–7 animals per group. NEFA, nonesterified fatty acid; Glucose and NEFA in sedentary group were measured in the fed state a P
Ian Ritchie (315016), Catherine B. Chan (294687), Marie-Soleil Beaudoin (315017), Laura Castellani (315018), Zhongxiao Wan (294685), David C. Wright (294688)   +5 more
core   +1 more source

Pharmacological and Therapeutic Potential of Garlic (Allium sativum): Integrating Phytochemistry, Molecular Mechanisms, and Clinical and Preclinical Evidence

ChemistryOpen, Volume 15, Issue 11, November 2026.
Garlic bioactive compounds, including organosulfur compounds (allicin, DADS, DATS, and SAC), phenolic compounds, and quercetin, regulate the Nrf2/HO‐1, NF‐κB, PI3K/Akt, and AMPK/eNOS signaling pathways. These actions enhance antioxidant defenses, suppress inflammation, improve metabolic and cardiovascular function, and contribute to reduced blood ...
Gudisa Bereda
wiley   +1 more source

Concentrations of Serum Non-Esterified Fatty Acid (NEFA) and BetaHydroxybutyrate (BHB) through the Transition Period and their Associations with Risk of Clinical Disease

, 2007
Serum non-esterified fatty acid (NEFA) and Beta-Hydroxybutyrate (BHB) concentrations provide important insight into the metabolic health of transition dairy cows. Previous studies have linked elevated prepartum NEFA and postpartum BHB concentrations with
Santos, J. E., LeBlanc, S. J., Godden, S. M., Carson, M. E., Capel, M. B., Overton, M. W.   +5 more
core   +1 more source

Cullin 3 mitigates nonesterified fatty acid–induced oxidative stress in mammary epithelial cells: Involvement of BCL2/BECN1 and autophagy

Journal of Dairy Science
: High nonesterified fatty acid (NEFA) concentrations in cows with clinical ketosis lead to metabolic dysfunction in mammary cells, resulting in oxidative stress.
Yifei Dong, Wenwen Gao, Kai Liu, Cai Lin, Muhammad Usman, Juan J. Loor, Guojin Li, Liguang Cao, Zifeng Yang, Jianchun Luo, Depeng Li, Qianwen Sun, Lin Lei, Xiliang Du, Yuxiang Song, Guowen Liu, Xinwei Li   +16 more
doaj   +1 more source

Hepatic Overexpression of Lysophospholipid Acyltransferase LPLAT14/MBOAT1 Ameliorates Mild Liver Injury During Early High‐Fat Diet Feeding

FASEB BioAdvances, Volume 8, Issue 11, November 2026.
Using an improved adenovirus vector, we investigated the effects of hepatic LPLAT14 overexpression on high‐fat diet (HFD)‐induced metabolic disorders and mild liver injury in mice. LPLAT14 selectively increased oleic acid (OA)‐containing phosphatidylserine (PS) species in the liver. This specific lipidomic remodeling attenuated mild liver injury during
Sho Hori, Kahori Shimizu, Taiga Kikuchi, Hajime Miyata, Hiroaki Hase, Hiroki Nakanishi, Hideo Shindou, Hiroyuki Mizuguchi   +7 more
wiley   +1 more source