Results 81 to 90 of about 15,236 (204)

Caveolin 1 ameliorates nonesterified fatty acid–induced oxidative stress via the autophagy regulator beclin 1 in bovine mammary gland epithelial cells

Journal of Dairy Science
: High blood concentrations of nonesterified fatty acids (NEFA) during ketosis enhance uptake by the mammary gland and impair autophagy while causing oxidative stress.
Kai Liu, Yifei Dong, Liguang Cao, Guojin Li, Zifeng Yang, Jianchun Luo, Lin Lei, Xiliang Du, Yuxiang Song, Muhammad Usman, Juan J. Loor, Guowen Liu, Xinwei Li, Wenwen Gao   +13 more
doaj   +1 more source

Estrogen Receptor Beta Activation Coordinates Liver Lipid Remodeling and Metabolic Fluxes, Preventing Lipotoxicity

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
ERβ activation restores glucose and lipid homeostasis by remodeling the hepatic lipidome. Mechanistically, it promotes complete fatty acid oxidation and decreases Acetyl‐CoA levels, leading to reduced ketogenesis and lipotoxicity, as demonstrated through in vivo and in vitro approaches.
Debora Santos Rocha, Eloisa Vilas‐Boas, Camille C. Caldeira da Silva, Everton L. Vogt, Marcos Yoshinaga, Mariana Pacheco Teixeira de Carvalho, Maiara I. C. Queiroz, Tiago Eugênio Oliveira da Silva, Sayuri Miyamoto, Alicia J. Kowaltowski   +9 more
wiley   +1 more source

Co-ordination of hepatic and adipose tissue lipid metabolism after oral glucose

Journal of Lipid Research, 1999
The integration of lipid metabolism in the splanchnic bed and in subcutaneous adipose tissue before and after ingestion of a 75 g glucose load was studied by Fick's principle in seven healthy subjects.
Jens Bülow, Lene Simonsen, David Wiggins, Sandy M. Humphreys, Keith N. Frayn, David Powell, Geoffrey F. Gibbons   +6 more
doaj   +1 more source

The Postprandial Chronobiome in Interorgan Glucose Homeostasis

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
The postprandial chronobiome framework proposes that meal‐timed oscillations in microbial communities and metabolites may interact with host tissue clocks to shape glucose handling. The liver is the best‐supported temporal interpreter, while phase‐aware human studies are needed to establish causal interorgan effects.
Josko Bozic, Roko Santic, Marko Kumric
wiley   +1 more source

Chemokine receptor CCR1 restrains adipose tissue remodelling via cAMP/PKA/CREB signalling and adipocyte‒macrophage crosstalk in mice

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
CCR1 expression is significantly elevated in adipose tissue of obese individuals. Systemic and adipocyte‐specific Ccr1 deletion promotes fat browning via cAMP/PKA/CREB activation and M2 macrophage polarisation, protecting against obesity. Pharmacological blockade of CCR1 suppresses obesity progression, highlighting its potential as a novel target for ...
Suili Cai, Mengchen Ma, Yuqin Zhu, Mengru Shi, Xiaoyan Dai, Yujie Wang, Mengru Li, Yanwen Yu, Yajiao Wang, Liang Xu   +9 more
wiley   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Structure‐Guided Extremophile Genome Mining Expands the PETase Landscape and Reveals PET‐Hydrolysing True Lipase Lineages

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
Genome mining of extremophiles revealed previously unknown PET‐hydrolising true lipases. Structural and functional analyses identified determinants of dual lipase–PETase activity and expanded the repertoire of microbial biocatalysts available for sustainable PET recycling.
Rubén Muñoz‐Tafalla, José M. González‐Romero, Paula Vidal, Laura Fernandez‐Lopez, Ana Robles‐Martín, David Almendral, José L. Gonzalez‐Alfonso, Francisco J. Plou, Manuel Ferrer, Víctor Guallar, Rafael Bargiela   +10 more
wiley   +1 more source

The In Vitro Effects of Choline on Non-Esterified Fatty Acid-Treated Bovine Peripheral Blood Leukocytes

Animals
The transition period is defined as 3 weeks around parturition, involving the rapid increase in the energy demand, promoting adipose mobilization and non-esterified fatty acid (NEFA) release.
Cheng-Yan Li, Yueh-Tung Chen, Tossapol Moonmanee, Jacky Peng-Wen Chan, Chien-Kai Wang   +4 more
doaj   +1 more source

Dose–Response Effect of Glucagon on Glucose, Beta‐Cell Secretion and Metabolism in Healthy Individuals

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6941-6949, August 2026.
ABSTRACT Aim Glucagon is a key regulator of glucose and energy metabolism, yet the dose–response effects of glucagon on markers of metabolism in humans are not fully characterised. We investigated the dose‐dependent effects of glucagon on glucose metabolism, β‐cell secretion and markers of hepatic metabolism in healthy adults.
Sophie Betty Brock, Nina Lerberg Hansen, Elvar Már Sturlaugsson Jóhönnuson, Sasha Alexandra Sampson Kjeldsen, Nicolai J. Wewer Albrechtsen   +4 more
wiley   +1 more source

Fast & fuelious: the malate–aspartate shuttle in brown adipocyte lipid metabolism

The FEBS Journal, Volume 293, Issue 15, Page 4480-4483, August 2026.
Brown adipose tissue (BAT) produces heat in response to cold exposure, for which it relies on the coordination of aerobic and anaerobic metabolism. However, how reaction intermediates connect these two essential pathways is unclear. In this issue of The FEBS Journal, Veliova et al., report that the malate–aspartate shuttle (MAS) supports norepinephrine‐
Lukas Blaas, Alexander Bartelt
wiley   +1 more source