Results 61 to 70 of about 19,678 (222)

Transcriptome Analysis Reveals That NEFA and β-Hydroxybutyrate Induce Oxidative Stress and Inflammatory Response in Bovine Mammary Epithelial Cells

Metabolites, 2022
Non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHBA) are the metabolites of fat mobilization initiated by negative energy balance (NEB) during the perinatal period in dairy cows, which have an adverse effect on cell physiology of various bovine
Chengmin Li, Junpeng Huang, Xiangxing Chen, Yexiao Yan, Lian Li, Weiguo Zhao   +5 more
doaj   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowly

, 2014
OBJECTIVE: Meal duration may influence cardiometabolic health. The aim of this study was to explore postprandial effects of meal duration on human metabolism and appetite.
Halder, Louise, Piya, Milan K. (R19111), Reddy, N.L., Peng, C, Barber, Thomas M., Casanueva, FF, Casanueva, Felipe F., Thomas M. Barber, Tripathi, G, Hattersley, John G., Casanueva, F.F., Carreira, MC, Kumar, S., Casanueva, F.F, McTernan, Philip G., Marcos C. Carreira, Piya, M.K, Milan K. Piya, Casanueva, F. F, Reddy, Narendra L., Casanueva Freijo, Felipe, Halder, L., John Hattersley, Piya, Milan K., Tripathi, Gyanendra, Randeva, Harpal S., McTernan, P. G., Piya, M.K., Hattersley, J, Barber, T.M., Peng, Chenjing, Halder, L, Piya, MK, Chenjing Peng, Carreira, Marcos C., McTernan, P.G, McTernan, PG, Sudhesh Kumar, Reddy, N.L, Hattersley, J., Barber, TM, Felipe F. Casanueva, Carreira, C., Harpal S. Randeva, Tripathi, G., Louise Halder, Philip G. McTernan, Barber, T. M., Randeva, HS, Peng, C., Reddy, NL, Gyanendra Tripathi, Kumar, Sudhesh, Narendra L. Reddy, Reddy, Narendra Lakshmana, Carreira, M.C, McTernan, P.G., Kumar, S, Peng, C.J., Carreira, M.C., Randeva, H.S., Randeva, H.S   +61 more
core   +1 more source

Evaluation of the diagnostic accuracy of a point-of-care device to measure concentrations of nonesterified fatty acids in serum and whole blood

JDS Communications, 2023
The objective of this study was to compare measurements of nonesterified fatty acids (NEFA) between the gold standard diagnostic laboratory method and a handheld NEFA meter (Qucare Pro meter, DFI Co. Ltd.).
P.L. Venjakob, L.F. Bretzinger, S. Borchardt, C. Weber, W. Heuwieser   +4 more
doaj   +1 more source

Dose–Response Effect of Glucagon on Glucose, Beta‐Cell Secretion and Metabolism in Healthy Individuals

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Glucagon is a key regulator of glucose and energy metabolism, yet the dose–response effects of glucagon on markers of metabolism in humans are not fully characterised. We investigated the dose‐dependent effects of glucagon on glucose metabolism, β‐cell secretion and markers of hepatic metabolism in healthy adults.
Sophie Betty Brock, Nina Lerberg Hansen, Elvar Már Sturlaugsson Jóhönnuson, Sasha Alexandra Sampson Kjeldsen, Nicolai J. Wewer Albrechtsen   +4 more
wiley   +1 more source

Pre‐Exercise Galactose or Lactose Reduces Glycaemic Excursions During Exercise in Adults With Type 1 Diabetes: A Randomised, Double‐Blind, Crossover Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To test whether pre‐exercise galactose and lactose reduce glycaemic excursions during exercise compared with dextrose while maintaining protection against hypoglycaemia compared with placebo in adults with Type 1 diabetes Methods In a randomised, double‐blind, 4‐condition crossover trial, 14 adults with Type 1 diabetes completed four 60 ...
Karoline R. Schmidt, Rakel F. Johansen, Simon B. Riis, Mads S. Larsen, Henrik Støvring, Gareth A. Wallis, David Rowlands, Lars C. Gormsen, Esben Søndergaard   +8 more
wiley   +1 more source

Differences in the serum nonesterified Fatty Acid profile of young women associated with a recent history of gestational diabetes and overweight/obesity. [PDF]

PLoS ONE, 2015
Nonesterified fatty acids (NEFA) play pathophysiological roles in metabolic syndrome and type 2 diabetes (T2D). In this study, we analyzed the fasting NEFA profiles of normoglycemic individuals at risk for T2D (women with a recent history of gestational ...
Marina Fugmann, Olaf Uhl, Christian Hellmuth, Holger Hetterich, Nora N Kammer, Uta Ferrari, Klaus G Parhofer, Berthold Koletzko, Jochen Seissler, Andreas Lechner   +9 more
doaj   +1 more source

Subgroups of Adult‐Onset Diabetes: A Prospective Follow‐Up Study of Progression of Insulin Resistance and Deficiency and Association With Liver Steatosis and Fibrosis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To assess progression of insulin deficiency and resistance in diabetes, the stability of cluster‐based subgrouping, and the association between steatotic liver disease (SLD), liver fibrosis (LF), and tissue insulin resistance. Materials and Methods Participants from a regional diabetes register were studied within 3 years from diagnosis ...
Aleksi Laitinen, Annemari Käräjämäki, Aki J. Käräjämäki, Samu Kurki, Liisa Hakaste, Olof Asplund, Johan Hultman, Kaj Lahti, Mikko Lehtovirta, Emma Ahlqvist, Tiinamaija Tuomi   +10 more
wiley   +1 more source

ADMINISTRATION OF EARLY POST-PARTUM ORAL DRENCH IN DAIRY COWS: EFFECTON METABOLIC PROFILE

Revista de la Facultad de Medicina Veterinaria y de Zootecnia, 2015
Some prophylactic treatments have been proposed in high-yielding dairy cattle in order to minimize the effects of negative energy balance and some disturbances such as hypocalcaemia and ketosis.
R. Schallenberger Gonçalves, F. Cardoso, F. de Souza Guagnini, L. J. Reyes Castañeda, F. Gonzalez   +4 more
doaj  

Aerobic Exercise Training Increases Circulating sRAGE in Adults With Type 2 Diabetes: Associations With Sheddase Regulation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective Soluble receptor for advanced glycation end‐products (sRAGE) and soluble Toll‐like receptor 4 (sTLR4) are circulating pattern recognition receptor isoforms implicated in inflammatory regulation in type 2 diabetes mellitus (T2DM). This study examined the effects of supervised aerobic exercise training (AET) on circulating sRAGE, sTLR4,
Ryan K. Perkins, Corey E. Mazo, James Shadiow, Pallavi Varshney, Edwin R. Miranda, Victoria R. Miranda, Maggie Eisenberg, Jane E. Nakamura, Elif A. Oral, Jacob M. Haus   +9 more
wiley   +1 more source