Results 71 to 80 of about 23,293 (232)

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Mogroside V Promotes Brown Adipose Thermogenesis via FTO‐m6A‐LETMD1‐UCP1 Pathway to Combat Obesity

Phytotherapy Research, EarlyView.
Mogroside V (MV) alleviates high‐fat diet‐induced obesity and metabolic dysfunction. Mechanistically, MV suppresses FTO expression, thereby increasing m6A modification of Letmd1 mRNA and enhancing its YTHDC2‐dependent stabilization. Theincreased LETMD1 expression is associated with elevated PGC1α and UCP1 levels, contributing to brown adipocyte ...
Yuan‐hai Sun, Ling‐huan Li, Ya‐qian Feng, Teng‐jiao Zhao, Min‐you Qi, Han‐bing Li   +5 more
wiley   +1 more source

Emergence of Indian National Congress and Its Role in State Politics of Arunachal Pradesh

Dera Natung Government College Research Journal, 2018
The political activities in Arunachal Pradesh are of recent origin as it remains unexposed to outer world for long time. Traditional socio-political institutions of various tribal communities were primarily responsible for managing people’s day-to-day ...
Nyajum Lollen
doaj  

Effect of Non-Esterified Fatty Acids on Fatty Acid Metabolism-Related Genes in Calf Hepatocytes Cultured in Vitro

Cellular Physiology and Biochemistry, 2013
Background: NEFA plays numerous roles in the metabolism of glucose, lipids, and proteins. A number of experimental studies have shown that NEFA may have an important role in fatty acid metabolism in the liver, especially in dairy cows that experience ...
Peng Li, Yiming Liu, Yi Zhang, Miao Long, Yang Guo, Zhe Wang, Xinwei Li, Cai Zhang, Xiaobing Li, Jianbin He, Guowen Liu   +10 more
doaj   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

α-klotho in pregnancy toxemia in goats: a new biomarker candidate? [PDF]

Eurasian Journal of Veterinary Sciences
This study aimed to evaluate the potential use of serum α-Klotho as a biomarker in pregnancy toxemia. The study included 45 Damascus goats that had given birth at least once and were between 120 and 150 days of gestation, brought to the Animal Hospital ...
Omer Yaprakci, Tugra Akkus
doaj  

NEFA levels in HC and RA patients.

, 2016
Heatmap of NEFA serum levels showing the different NEFA species (columns). Each row corresponds with an individual. Colours in the vertical bar at the left of the heatmap identifies healthy controls (yellow), NEFAhigh RA patients (brown) and NEFAlow RA ...
Javier Rodríguez-Carrio (474343), Mercedes Alperi-López (511456), Francisco Javier Ballina-García (511457), Patricia López (64361), Ana Suárez (64365)   +4 more
core   +1 more source

Serum growth differentiation factor-15 and non-esterified fatty acid levels in patients with coronary artery disease and hyperuricemia

Lipids in Health and Disease, 2023
Background High serum NEFA and GDF-15 are risk factors for CAD and have been linked to detrimental cardiovascular events. It has been hypothesized that hyperuricemia causes CAD via the oxidative metabolism and inflammation.
Jingru Cheng, Yongnan Lyu, Yufeng Mei, Qian Chen, Hang Liu, Yan Li   +5 more
doaj   +1 more source

Differences in the serum nonesterified Fatty Acid profile of young women associated with a recent history of gestational diabetes and overweight/obesity. [PDF]

PLoS ONE, 2015
Nonesterified fatty acids (NEFA) play pathophysiological roles in metabolic syndrome and type 2 diabetes (T2D). In this study, we analyzed the fasting NEFA profiles of normoglycemic individuals at risk for T2D (women with a recent history of gestational ...
Marina Fugmann, Olaf Uhl, Christian Hellmuth, Holger Hetterich, Nora N Kammer, Uta Ferrari, Klaus G Parhofer, Berthold Koletzko, Jochen Seissler, Andreas Lechner   +9 more
doaj   +1 more source

Diet‐Related Differences Predominate Over Breed‐Associated Differences in Hepatic Lipid Metabolism, Antioxidant Vitamins and Lipid Quality Indices Among Beef Cattle

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Understanding how nutritional management and genetic background influence hepatic metabolism is important for improving the nutritional quality of bovine products in tropical production systems. This study evaluated breed‐associated differences under a common dietary regimen and diet‐related differences within the Nelore breed with respect to ...
Laíza de Kássia Mendes da Conceição, José de Brito Lourenço‐Júnior, Jamile Andréa Rodrigues da Silva, Leonel António Joaquim, Mariana Jucá Moraes, Thomaz Cyro Guimarães de Carvalho Rodrigues, Joana Inês Ferreira, Ana Maria Ramos Fontes, Maria Pinheiro Spínola, Érica Coutinho David, Antônio Vinicius Correa Barbosa, Bruno Cabral Soares, José António Mestre Prates   +12 more
wiley   +1 more source