Acute effects of elevated NEFA on vascular function: a comparison of SFA and MUFA [PDF]
British Journal of Nutrition, 2010 There is emerging evidence to show that high levels of NEFA contribute to endothelial dysfunction and impaired insulin sensitivity. However, the impact of NEFA composition remains unclear.
Abby K. Thompson +9 more
core +5 more sources
Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2+ [PDF]
Diabetologia, 2018 Aims/hypothesisThe blood triacylglycerol level is one of the main determinants of blood Mg2+ concentration in individuals with type 2 diabetes.
S. Kurstjens +15 more
semanticscholar +5 more sources
Influence of endogenous NEFA on beta cell function in humans [PDF]
Diabetologia, 2015 It is a commonly held view that chronically elevated NEFA levels adversely affect insulin secretion and insulin action (lipotoxicity). However, the effect of NEFA on beta cell function has only been explored using acute NEFA elevations. Our aim was to analyse the relationship between endogenous NEFA levels and beta cell function.In 1,267 individuals ...
E. Rebelos +9 more
semanticscholar +6 more sources
Xylitol prevents NEFA-induced insulin resistance in rats [PDF]
Diabetologia, 2012 Increased NEFA levels, characteristic of type 2 diabetes mellitus, contribute to skeletal muscle insulin resistance. While NEFA-induced insulin resistance was formerly attributed to decreased glycolysis, it is likely that glucose transport is the rate-limiting defect.
P. Kishore +7 more
semanticscholar +4 more sources
Physiological regulation of NEFA availability: lipolysis pathway [PDF]
Proceedings of the Nutrition Society, 2004 Plasma NEFA are an important energy substrate and, furthermore, play a key role in the induction of insulin resistance in the body. The availability of NEFA is determined predominantly by their mobilization from adipose tissue triacylglycerol stores by the process of lipolysis.
V. Štich, M. Berlan
semanticscholar +3 more sources
A Model of NEFA Dynamics with Focus on the Postprandial State
Annals of Biomedical Engineering, 2009 To improve the understanding of the mechanisms underlying the behavior of plasma non-esterified fatty acids (NEFA) in the postprandial state, we have developed a physiology-based mathematical model of plasma NEFA dynamics. Known physiological mechanisms are quantified and used to describe NEFA dynamics. Insulin is the major regulator of NEFA metabolism
Katarina Jelic +2 more
semanticscholar +5 more sources
A Tale of Two Biomarkers: Untargeted 1H NMR Metabolomic Fingerprinting of BHBA and NEFA in Early Lactation Dairy Cows [PDF]
Metabolites, 2020 Disorders of energy metabolism, which can result from a failure to adapt to the period of negative energy balance immediately after calving, have significant negative effects on the health, welfare and profitability of dairy cows.
T.D.W. Luke +3 more
openalex +2 more sources
n-3 NEFA: vascular implications [PDF]
European Heart Journal, 2002 P. Gerry Fegan
openalex +3 more sources
Association of NEFA composition with insulin sensitivity and beta cell function in the Prospective Metabolism and Islet Cell Evaluation (PROMISE) cohort [PDF]
Diabetologia, 2017 Luke Johnston +6 more
openalex +2 more sources
Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes [PDF]
Diabetologia, 2012 Aims/hypothesisType 2 diabetes mellitus is associated with reduced incretin effects. Although previous studies have shown that hyperglycaemia contributes to impaired incretin responses in beta cells, it is largely unknown how hyperlipidaemia, another ...
Zhanfang Kang +7 more
openalex +2 more sources