Results 11 to 20 of about 15,236 (204)

High Concentrations of Non-Esterified Fatty Acids During Bovine In Vitro Fertilisation Are Detrimental for Spermatozoa Quality and Pre-Implantation Embryo Development [PDF]

Journal of Developmental Biology
High non-esterified fatty acids (NEFAs) during negative energy balance in dairy cattle can impair reproduction. While their effects on oocyte maturation and preimplantation embryo development are known, their impact during fertilisation is largely ...
Abdullah F. Idriss, Edward J. Okello, Roger G. Sturmey, Miguel A. Velazquez   +3 more
doaj   +2 more sources

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Circulating Non-Esterified Fatty Acids as Biomarkers for Fat Content and Composition in Pigs

Animals, 2021
Circulating non-esterified fatty acids (NEFA) can reflect the composition of dietary fat or adipose tissues depending on the fasting conditions. Therefore, circulating NEFA may be valuable as biomarkers for meat quality traits, such as intramuscular fat ...
Marc Tor, Francesca Vilaró, Roger Ros-Freixedes, Javier Álvarez-Rodríguez, Lluís Bosch, Sofia Gol, Ramona N. Pena, Josep Reixach, Joan Estany   +8 more
doaj   +1 more source

Non-esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway

Antioxidants, 2020
Negative energy balance (NEB) during the perinatal period can affect dairy cow follicular development and reduce the fecundity. Non-esterified fatty acid (NEFA) concentration is elevated during NEB, and is known to be toxic for multiple cell types.
Yiru Wang, Chengmin Li, Julang Li, Genlin Wang, Lian Li   +4 more
doaj   +1 more source

Association between prepartum nonesterified fatty acid serum concentrations and postpartum diseases in dairy cows

Journal of Dairy Science, 2022
: The objective of the present study was to quantify the relationships between prepartum nonesterified fatty acid (NEFA) concentrations and the development of subsequent diseases or culling and to identify the optimal thresholds allowing identification ...
I. Nicola, H. Chupin, J.-P. Roy, S. Buczinski, V. Fauteux, N. Picard-Hagen, R. Cue, J. Dubuc   +7 more
doaj   +1 more source

Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2+ [PDF]

Diabetologia, 2018
The blood triacylglycerol level is one of the main determinants of blood Mg2+ concentration in individuals with type 2 diabetes. Hypomagnesaemia (blood Mg2+ concentration 27 kg/m2) who participated in the 300-Obesity study (an observational cross-sectional cohort study, as part of the Human Functional Genetics Projects), we investigated the association
Kurstjens, S, de Baaij, JHF, Overmars-Bos, C, Van Den Munckhof, ICL, Garzero, V, De Vries, MA, Burggraaf, B, Van Diepen, JA, Riksen, NP, Rutten, JHW, Netea, MG, Cabezas, M, Bindels, RJM, Ashcroft, FM, Tack, CJJ, Hoenderop, JGJ   +15 more
openaire   +4 more sources

Solvent-extracted soybean meal top-dressed on a fresh cow diet increased milk production, but not milk components, and decreased plasma non-esterified fatty acids

Czech Journal of Animal Science, 2019
Post-ruminally infused casein has increased milk and milk protein yield in post-partum cows. We theorised top dressing (TD) higher amounts of soybean meal (SBM) might mimic these effects.
Mohammad Ghelichkhan, Hamid Amanlou, Ehsan Mahjoubi, Robert A. Patton   +3 more
doaj   +1 more source

Impaired Ratio of Unsaturated to Saturated Non-Esterified Fatty Acids in Saliva from Patients with Cystic Fibrosis

Diagnostics, 2020
Impaired salivary non-esterified fatty acids (NEFA) levels have been previously observed in cystic fibrosis (CF). This study aimed to characterize the salivary NEFA profile in CF and to examine whether the alterations are related to the pancreatic status
Monica Gelzo, Paola Iacotucci, Vincenzo Carnovale, Alice Castaldo, Marika Comegna, Gustavo Cernera, Gaetano Corso, Giuseppe Castaldo   +7 more
doaj   +1 more source

Inhibition of cluster antigen 36 protects against fatty acid-induced lipid accumulation, oxidative stress, and inflammation in bovine hepatocytes

Journal of Dairy Science, 2023
: When ketosis occurs, supraphysiological concentrations of nonesterified fatty acids (NEFA) display lipotoxicity and are closely related to the occurrence of hepatic lipid accumulation, oxidative stress, and inflammation, resulting in hepatic damage and
Chenchen Zhao, Jinxia Li, Menglin Liu, Linfang Chen, Yiwei Zhu, Wenwen Gao, Xiliang Du, Yuxiang Song, Guowen Liu, Lin Lei, Xinwei Li   +10 more
doaj   +1 more source

Physiological regulation of NEFA availability: lipolysis pathway [PDF]

Proceedings of the Nutrition Society, 2004
Plasma NEFA are an important energy substrate and, furthermore, play a key role in the induction of insulin resistance in the body. The availability of NEFA is determined predominantly by their mobilization from adipose tissue triacylglycerol stores by the process of lipolysis.
V, Stich, M, Berlan
openaire   +2 more sources