Results 11 to 20 of about 19,678 (222)

Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2+ [PDF]

Diabetologia, 2018
The blood triacylglycerol level is one of the main determinants of blood Mg2+ concentration in individuals with type 2 diabetes. Hypomagnesaemia (blood Mg2+ concentration 27 kg/m2) who participated in the 300-Obesity study (an observational cross-sectional cohort study, as part of the Human Functional Genetics Projects), we investigated the association
Kurstjens, S, de Baaij, JHF, Overmars-Bos, C, Van Den Munckhof, ICL, Garzero, V, De Vries, MA, Burggraaf, B, Van Diepen, JA, Riksen, NP, Rutten, JHW, Netea, MG, Cabezas, M, Bindels, RJM, Ashcroft, FM, Tack, CJJ, Hoenderop, JGJ   +15 more
openaire   +6 more sources

Contribution of glycerophospholipids and sphingomyelin to the circulating NEFA

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2016
Serum nonesterified fatty acids (NEFA) are known to be associated with the development of insulin resistance. Recently, differences in the NEFA profile were found in subjects with history of gestational diabetes (postGDM) and healthy controls. Little is known about the NEFA sources in the postprandial state, which prevails most of the day in humans in ...
Felicitas Maier, Hans Demmelmair, Marina Fugmann, Christian Hellmuth, Andreas Lechner, Berthold Koletzko, Olaf Uhl   +6 more
openaire   +5 more sources

Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals [PDF]

International Journal of Endocrinology, 2013
Introduction. The mechanisms underlying the association between insulin resistance and intrahepatic lipid (IHL) accumulation are not completely understood.
Francis M. Finucane, Stephen J. Sharp, Mensud Hatunic, Alison Sleigh, Ema De Lucia Rolfe, Avan Aihie Sayer, Cyrus Cooper, Simon J. Griffin, David B. Savage, Nicholas J. Wareham   +9 more
doaj   +3 more sources

Quantitative and qualitative analysis of human salivary NEFA with gas-chromatography and mass spectrometry

Frontiers in Physiology, 2012
Salivary NEFA are proposed to play a role in oral health, oral fat detection, and they may hold diagnostic and prognostic potential. Yet, little is known about the array and concentrations of NEFA in saliva.
Bhushan V Kulkarni, Karl V Wood, Richard D Mattes   +2 more
doaj   +2 more sources

Effect of high NEFA concentration on lipid metabolism disorders in hepatocytes based on lipidomics [PDF]

Frontiers in Pharmacology
Introduction: High concentrations of nonesterified fatty acids (NEFA) is the key of characteristic of fatty liver in dairy cows. Therefore, the aim of this study was to investigate the effect of high concentration of NEFA on lipid metabolism in ...
Xinyi Fan, Jie Xu, Yuan Hu, Kui Wang, Yiyi Zhao, Jinyin Cai, Xinyuan Zhang, Binghai Pan, Anqi Xu, Yajing Chen, Songhao Liu, Kangfeng Jiang, Xiaobing Li   +12 more
doaj   +4 more sources

A Model of NEFA Dynamics with Focus on the Postprandial State

Annals of Biomedical Engineering, 2009
To improve the understanding of the mechanisms underlying the behavior of plasma non-esterified fatty acids (NEFA) in the postprandial state, we have developed a physiology-based mathematical model of plasma NEFA dynamics. Known physiological mechanisms are quantified and used to describe NEFA dynamics. Insulin is the major regulator of NEFA metabolism
Jelic, Katarina, Hallgreen, Christine E., Colding-Jørgensen, Morten   +2 more
openaire   +4 more sources

NDUFAB1 as a Novel Regulator of NEFA-Induced Metabolic Dysfunction in Bovine Adipocytes

Animals
Elevated non-esterified fatty acid (NEFA) levels are closely associated with metabolic disorders in dairy cattle, yet their direct effects on adipocyte physiology remain poorly understood.
Jing Zhou, Tao Tang, Wenqiang Sun, Xianbo Jia, Jie Wang, Hengwei Yu, Songjia Lai   +6 more
doaj   +2 more sources

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Non-esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway

Antioxidants, 2020
Negative energy balance (NEB) during the perinatal period can affect dairy cow follicular development and reduce the fecundity. Non-esterified fatty acid (NEFA) concentration is elevated during NEB, and is known to be toxic for multiple cell types.
Yiru Wang, Chengmin Li, Julang Li, Genlin Wang, Lian Li   +4 more
doaj   +1 more source

Solvent-extracted soybean meal top-dressed on a fresh cow diet increased milk production, but not milk components, and decreased plasma non-esterified fatty acids

Czech Journal of Animal Science, 2019
Post-ruminally infused casein has increased milk and milk protein yield in post-partum cows. We theorised top dressing (TD) higher amounts of soybean meal (SBM) might mimic these effects.
Mohammad Ghelichkhan, Hamid Amanlou, Ehsan Mahjoubi, Robert A. Patton   +3 more
doaj   +1 more source