Results 11 to 20 of about 23,293 (232)

Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals [PDF]

International Journal of Endocrinology, 2013
Introduction. The mechanisms underlying the association between insulin resistance and intrahepatic lipid (IHL) accumulation are not completely understood.
Francis M. Finucane, Stephen J. Sharp, Mensud Hatunic, Alison Sleigh, Ema De Lucia Rolfe, Avan Aihie Sayer, Cyrus Cooper, Simon J. Griffin, David B. Savage, Nicholas J. Wareham   +9 more
doaj   +3 more sources

Contribution of glycerophospholipids and sphingomyelin to the circulating NEFA

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2016
Serum nonesterified fatty acids (NEFA) are known to be associated with the development of insulin resistance. Recently, differences in the NEFA profile were found in subjects with history of gestational diabetes (postGDM) and healthy controls. Little is known about the NEFA sources in the postprandial state, which prevails most of the day in humans in ...
Felicitas Maier, Hans Demmelmair, Marina Fugmann, Christian Hellmuth, Andreas Lechner, Berthold Koletzko, Olaf Uhl   +6 more
openaire   +5 more sources

Are We Waking Up to the Effects of NEFA? [PDF]

Diabetologia, 2015
NEFA are mobilised from adipose tissues during fasting or stress. Under conditions of acute or chronic NEFA excess, skeletal muscle and hepatic insulin resistance may ensue. Hence, a wealth of literature has focused on the crosstalk between NEFA and glucose in the pathogenesis of insulin resistance.
Jonathan C Jun, Vsevolod Y Polotsky
exaly   +3 more sources

Xylitol Prevents NEFA-Induced Insulin Resistance in Rats [PDF]

Diabetologia, 2012
Increased NEFA levels, characteristic of type 2 diabetes mellitus, contribute to skeletal muscle insulin resistance. While NEFA-induced insulin resistance was formerly attributed to decreased glycolysis, it is likely that glucose transport is the rate-limiting defect.
Meredith Hawkins, M R El-Maghrabi, P Kishore   +2 more
exaly   +3 more sources

Influence of Endogenous NEFA on Beta Cell Function in Humans [PDF]

Diabetologia, 2015
It is a commonly held view that chronically elevated NEFA levels adversely affect insulin secretion and insulin action (lipotoxicity). However, the effect of NEFA on beta cell function has only been explored using acute NEFA elevations. Our aim was to analyse the relationship between endogenous NEFA levels and beta cell function.In 1,267 individuals ...
Andrea Mari, Eleuterio Ferrannini, Markku Laakso   +2 more
exaly   +6 more sources

Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2+ [PDF]

Diabetologia, 2018
The blood triacylglycerol level is one of the main determinants of blood Mg2+ concentration in individuals with type 2 diabetes. Hypomagnesaemia (blood Mg2+ concentration 27 kg/m2) who participated in the 300-Obesity study (an observational cross-sectional cohort study, as part of the Human Functional Genetics Projects), we investigated the association
Kurstjens, S, de Baaij, JHF, Overmars-Bos, C, Van Den Munckhof, ICL, Garzero, V, De Vries, MA, Burggraaf, B, Van Diepen, JA, Riksen, NP, Rutten, JHW, Netea, MG, Cabezas, M, Bindels, RJM, Ashcroft, FM, Tack, CJJ, Hoenderop, JGJ   +15 more
openaire   +6 more sources

Effect of high NEFA concentration on lipid metabolism disorders in hepatocytes based on lipidomics [PDF]

Frontiers in Pharmacology
Introduction: High concentrations of nonesterified fatty acids (NEFA) is the key of characteristic of fatty liver in dairy cows. Therefore, the aim of this study was to investigate the effect of high concentration of NEFA on lipid metabolism in ...
Xinyi Fan, Jie Xu, Yuan Hu, Kui Wang, Yiyi Zhao, Jinyin Cai, Xinyuan Zhang, Binghai Pan, Anqi Xu, Yajing Chen, Songhao Liu, Kangfeng Jiang, Xiaobing Li   +12 more
doaj   +2 more sources

NDUFAB1 as a Novel Regulator of NEFA-Induced Metabolic Dysfunction in Bovine Adipocytes

Animals
Elevated non-esterified fatty acid (NEFA) levels are closely associated with metabolic disorders in dairy cattle, yet their direct effects on adipocyte physiology remain poorly understood.
Jing Zhou, Tao Tang, Wenqiang Sun, Xianbo Jia, Jie Wang, Hengwei Yu, Songjia Lai   +6 more
doaj   +2 more sources

Metabolic biomarkers and milk production indicators associated with elevated non-esterified fatty acids in holstein dairy cows. [PDF]

BMC Vet Res
Background Negative energy balance (NEB) is a common metabolic challenge during early lactation in dairy cows and is characterized by increased mobilization of body fat reserves and elevated circulating non-esterified fatty acids (NEFA).
Grigė S, Girdauskaitė A, Sabeckienė I, Lembovičiūtė G, Šertvytytė G, Džermeikaitė K, Krištolaitytė J, Antanaitis R.   +7 more
europepmc   +2 more sources

Biochemical abnormality in the Brown Swiss breed cows affected with ketosis in the perinatal period

Theoretical and Applied Veterinary Medicine, 2023
Ketosis is widespread disturbance among dairy cows, causing significant economic losses and requiring further study of its pathogenesis. This particularly applies to less traditional dairy breeds, including the Brown Swiss.
V. H. Yefimov
doaj   +1 more source