Results 261 to 270 of about 3,750,504 (279)

and characterization of a novel negative allosteric modulator of neuronal nAChRs

Neuropharmacology, 2010
F Ivy Carroll, M Imad Damaj, Bruce E Blough   +2 more
exaly  

Negative allosteric modulation of the µ-opioid receptor

Biophysical Journal
Evan S. O'Brien, Vipin A. Rangari, Amal El Daibani, Shainnel O. Eans, Betsy White, Haoqing Wang, Yuki Shiimura, Kaavya Krishna Kumar, Kevin Appourchaux, Chensong Zhang, Jesper M. Mathiesen, Tao Che, Jay P. McLaughlin, Susruta Majumdar, Brian K. Kobilka   +14 more
openaire   +1 more source

Discovery of ONO-8590580: A novel, potent and selective GABA α negative allosteric modulator for the treatment of cognitive disorders

Bioorganic and Medicinal Chemistry Letters, 2020
exaly  

Discovery of (1,2)--(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator

Bioorganic and Medicinal Chemistry Letters, 2013
Junliang Hao, Edda F Roberts, James A Monn   +2 more
exaly  

Discovery of a Negative Allosteric Modulator of GABAB Receptors

ACS Medicinal Chemistry Letters, 2014
Jianfeng Liu, Fa-Jun Nan, Lin-Hai Chen
exaly  

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D receptor

Biochemical Pharmacology, 2018
Carmen Klein Herenbrink, Ben Capuano, Jonathan Javitch   +2 more
exaly  

NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2

2016
CONN P JEFFREY, LINDSLEY CRAIG W, EMMITTE KYLE A, FELTS ANDREW S, BOLLINGER KATRINA A   +4 more
openaire   +2 more sources

A Phase I randomized clinical trial testing the safety, tolerability and preliminary pharmacokinetics of the mGluR5 negative allosteric modulator GET 73 following single and repeated doses in healthy volunteers

European Journal of Pharmaceutical Sciences, 2017
Kimberly Goodyear, Carolina Haass-Koffler   +1 more
exaly  

Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2

ACS Chemical Neuroscience, 2017
Nicholas D P Cosford, Hye Jin Kang, Ming-Rong Zhang   +2 more
exaly  

Discovery of VU0431316: A negative allosteric modulator of mGlu with activity in a mouse model of anxiety

Bioorganic and Medicinal Chemistry Letters, 2014
Colleen M. Niswender, Carrie K Jones, Kyle A. Emmitte   +2 more
exaly