Quantifying negative selection on synonymous variants [PDF]
HGG AdvancesSummary: Widespread adoption of DNA sequencing has resulted in large numbers of genetic variants, whose contribution to disease is not easily determined.
Mikhail Gudkov +2 more
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Adaptation of Prokaryotic Toxins for Negative Selection and Cloning-Independent Markerless Mutagenesis in Streptococcus Species [PDF]
mSphere, 2023 The Streptococcus mutans genetic system offers a variety of strategies to rapidly engineer targeted chromosomal mutations. Previously, we reported the first S. mutans negative selection system that functions in a wild-type background.
Lena Li +5 more
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Oral delivery of peptides and proteins: pharmacokinetic boundaries, negative selection, and route triage [PDF]
Frontiers in Drug DeliveryOral delivery of peptides and proteins has been pursued for over a century due to its noninvasive nature. Despite sustained innovation across multiple technological generations—such as enteric coatings, enzyme inhibitors, permeation enhancers ...
Sarfaraz K. Niazi
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Genomic Features and Pervasive Negative Selection in Rhodanobacter Strains Isolated from Nitrate and Heavy Metal Contaminated Aquifer [PDF]
Microbiology Spectrum, 2022 Rhodanobacter species dominate in the Oak Ridge Reservation (ORR) subsurface environments contaminated with acids, nitrate, metal radionuclides, and other heavy metals.
Mu Peng +16 more
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Manufacture of CD22 CAR T cells following positive versus negative selection results in distinct cytokine secretion profiles and γδ T cell output [PDF]
Molecular Therapy: Methods & Clinical DevelopmentChimeric antigen receptor T cells (CART) have demonstrated curative potential for hematological malignancies, but the optimal manufacturing has not yet been determined and may differ across products.
Hannah W. Song +17 more
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Is T Cell Negative Selection a Learning Algorithm? [PDF]
Cells, 2020 Our immune system can destroy most cells in our body, an ability that needs to be tightly controlled. To prevent autoimmunity, the thymic medulla exposes developing T cells to normal “self” peptides and prevents any responders from entering ...
Inge M. N. Wortel +4 more
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A Clone Selection Based Real-Valued Negative Selection Algorithm [PDF]
Complexity, 2018 Excessive detectors, high time complexity, and loopholes are main problems which current negative selection algorithms have face and greatly limit the practical applications of negative selection algorithms.
Ruirui Zhang, Xin Xiao
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Journal of Modern Power Systems and Clean Energy, 2023 Considering a variety of sampled value (SV) attacks on busbar differential protection (BDP) which poses challenges to conventional learning algorithms, an algorithm to detect SV attacks based on the immune system of negative selection is developed in ...
Jun Mo, Hui Yang
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Thymic Microenvironment: Interactions Between Innate Immune Cells and Developing Thymocytes
Frontiers in Immunology, 2022 The thymus is a crucial organ for the development of T cells. T cell progenitors first migrate from the bone marrow into the thymus. During the journey to become a mature T cell, progenitors require interactions with many different cell types within the ...
Helen Wang +2 more
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Antibody Dynamics Simulation—A Mathematical Exploration of Clonal Deletion and Somatic Hypermutation
Biomedicines, 2023 We have employed mathematical modeling techniques to construct a comprehensive framework for elucidating the intricate response mechanisms of the immune system, facilitating a deeper understanding of B-cell clonal deletion and somatic hypermutation.
Zhaobin Xu +4 more
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