Results 41 to 50 of about 115,708 (268)

Affective neuroscience, emotional regulation, and international relations [PDF]

, 2019
International relations (IR) has witnessed an emerging interest in neuroscience, particularly for its relevance to a now widespread scholarship on emotions.
Gammon, Earl
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Zolpidem Activation of Alpha 1-Containing GABAA Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons

Frontiers in Pharmacology, 2019
Introduction: High frequency neuronal activity in the cerebral cortex can be induced by noxious stimulation during surgery, brain injury or poisoning. In this scenario, it is essential to block cortical hyperactivity to protect the brain against damage ...
Elena Neumann, Uwe Rudolph, Daniel E. Knutson, Guanguan Li, James M. Cook, Harald Hentschke, Bernd Antkowiak, Bernd Antkowiak, Berthold Drexler   +8 more
doaj   +1 more source

What Are the Human-Specific Aspects of Neocortex Development?

Frontiers in Neuroscience, 2022
When considering what makes us human, the development of the neocortex, the seat of our higher cognitive abilities, is of central importance. Throughout this complex developmental process, neocortical stem and progenitor cells (NSPCs) exert a priming ...
Felipe Mora-Bermúdez, Wieland B. Huttner   +1 more
doaj   +1 more source

Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding

, 2018
Background: We sought to determine if ripple oscillations (80-120Hz), detected in intracranial EEG (iEEG) recordings of epilepsy patients, correlate with an enhancement or disruption of verbal episodic memory encoding.
Berry, Brent, Camarillo-Rodriguez, Liliana, Chervenova, Inna, Das, Sandhitsu, Davis, Katheryn A., Davis, Leon A., Elahian, Bahareh, Ganne, Chaitanya, Gorniak, Richard, Gross, Robert, He, Xiao-Song, Inman, Cory S., Jobst, Barbara C., Khadjevand, Mehraneh, Kucewicz, Michal, Lega, Bradley C., Rizzuto, Daniel S., Sharan, Ashwini D., Shimamoto, Shoichi, Sperling, Michael, Stein, Joel, Tracy, Joseph, Waldman, Zachary J., Wanda, Paul, Weiss, Shennan A., Worrell, Gregory, Zaghloul, Kareem   +26 more
core   +1 more source

Cognitive Status in People With Epilepsy in the Republic of Guinea: A Prospective, Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick, Cheick O. Soumah, Malé Doré, Oumar Mara, Desiré Neldje, Fodé A. Cissé, Toure M. Lamine, Aminata Diallo, Seungwon Lee, Siddharth Satish, Alexander J. X. Chen, Alice Liu, Nomin Enkhtsetseg, Farrah J. Mateen, The Guinea Epilepsy Project   +14 more
wiley   +1 more source

Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex

eLife
In the cerebellum, climbing fibers (CFs) provide instructive signals for supervised learning at parallel fiber to Purkinje cell synapses. It has not been tested so far whether CF signaling may also influence plasticity in other brain areas. Here, we show
Abby Silbaugh, Kevin P Koster, Christian Hansel   +2 more
doaj   +1 more source

The Functioning of a Cortex without Layers

Frontiers in Neuroanatomy, 2017
A major hallmark of cortical organization is the existence of a variable number of layers, i.e., sheets of neurons stacked on top of each other, in which neurons have certain commonalities. However, even for the neocortex, variable numbers of layers have
Julien Guy, Jochen F. Staiger, Jochen F. Staiger   +2 more
doaj   +1 more source

Distinctive Structural and Molecular Features of Myelinated Inhibitory Axons in Human Neocortex. [PDF]

, 2018
Numerous types of inhibitory neurons sculpt the performance of human neocortical circuits, with each type exhibiting a constellation of subcellular phenotypic features in support of its specialized functions.
Chang, Edward F, Cobbs, Charles, Lein, Ed, Madison, Daniel V, Micheva, Kristina D, Nana, Alissa L, Seeley, William W, Smith, Stephen J, Ting, Jonathan T, Weinberg, Richard J   +9 more
core   +1 more source

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source