Results 131 to 140 of about 2,682,293 (230)

Habitual Diet, Gut Microbiome Dysbiosis, and α‐Synucleinopathy Conversion in Isolated Rapid Eye Movement (REM) Sleep Behavior Disorder

Movement Disorders, EarlyView.
Abstract Background Accumulating evidence indicates that habitual diet, including plant‐based dietary patterns, is associated with neurodegenerative α‐synucleinopathy risk. However, the role of diet and its correlation with the gut microbiome in prodromal α‐synucleinopathy, specifically among patients with isolated rapid eye movement (REM) sleep ...
Suyi Xie, Yuhua Yang, Shi Tang, Li Zhou, Jing Wang, Joey W.Y. Chan, Brian Or, Ningning Li, Siyi Gong, Zhixuan He, Jianzhang Ni, Yaping Liu, Jihui Zhang, Paul K.S. Chan, Zigui Chen, Sunny Hei Wong, Vincent C.T. Mok, Ngan Yin Chan, Steven W.H. Chau, Yun Kwok Wing, Bei Huang   +20 more
wiley   +1 more source

Cortical Cholinergic Pathway Degeneration Reflects Cognitive Impairment and Dementia in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Cognitive impairment is a prevalent and debilitating feature of Parkinson's disease (PD). Increasing evidence from postmortem and in vivo positron emission tomography imaging studies supports cholinergic dysfunction in PD. There is, however, little evidence regarding the influence of the structural integrity of cortical cholinergic ...
Nicola M. Slater, Daniel J. Myall, Reza Shoorangiz, Wassilios G. Meissner, Ian J. Kirk, Ross J. Keenan, Rebecca M. Lee, Kyla‐Louise Horne, Michael R. MacAskill, Campbell J. Le Heron, Toni L. Pitcher, Tim J. Anderson, Tracy R. Melzer, John C. Dalrymple‐Alford   +13 more
wiley   +1 more source

Potential value of slow‐wave sleep in management of chronic insomnia disorder

Sleep Research, EarlyView.
Abstract Chronic insomnia disorder (CID), acknowledged as the most common sleep disorder, has traditionally been diagnosed and managed with a focus on reducing sleep onset latency and extending total sleep duration. However, the critical importance of slow‐wave sleep (SWS), a key indicator of objective sleep quality, has been largely overlooked in ...
Liping Zhang, Qi Wu, Mengmeng Fan, Xianchao Zhao, Changjun Su   +4 more
wiley   +1 more source

Volumetric Comparison of Overall Brain and Neuropil Size Between Social and Non‐social Spiders: Exploring the Social Brain Hypothesis

Integrative Zoology, EarlyView.
Brain size may be influenced by the cognitive demands of sociality (social brain hypothesis). We used microCT to compare CNS and brain volumes in social versus solitary huntsman and crab spiders. Social huntsman spiders had larger arcuate and mushroom bodies, while social crab spiders had larger visual neuropils.
Vanessa Penna‐Gonçalves, Donald James Mclean, Nikolas J. Willmott, Michael B. J. Kelly, Jay R. Black, Elizabeth C. Lowe, Marie E. Herberstein   +6 more
wiley   +1 more source

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies

Brain Pathology, EarlyView.
Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom, Pawel Palmowski, Andrew Porter, Joe O'Neill, Johannes Attems, Laura A. Smith, Viktor I. Korolchuk, Daniel Erskine   +7 more
wiley   +1 more source

Clinicopathological and molecular heterogeneity of amyloid‐β in unnatural deaths under 70 years: A forensic autopsy–based study

Brain Pathology, EarlyView.
This study investigates amyloid‐beta (Aβ) pathology in a forensic autopsy cohort of relatively young individuals (40–69 years). Using detailed immunohistochemical analyses of multiple Aβ species, we demonstrate marked regional and molecular heterogeneity, particularly within the striatum.
Shojiro Ichimata, Yukiko Hata, Koji Yoshida, Ryo Tanaka, Shigeo Murayama   +4 more
wiley   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

The proto-cortical amygdala: a perspective on the functional and evolutionary relationship between the basolateral amygdala complex and neocortex in mammals. [PDF]

Brain Struct Funct
James FLJ, Ahamed SK, Yang C, Wilson R, Canales JJ, Caruso V, Johnson LR.   +6 more
europepmc   +1 more source

Neuropathology of a patient with Parkinson's disease and biallelic expansion in RFC1

Brain Pathology, EarlyView.
This is the first report of neuropathology in biallelic RFC1 expansion‐associated Parkinson’s disease (PD). It shows a synucleinopathy of intraneuronal Lewy bodies consistent with the clinical PD diagnosis while neuropathological CANVAS (Cerebellar Ataxia with Neuropathy and bilateral Vestibular Areflexia) features were absent.
Jussi Sipilä, Tuomas Rauramaa, Laura Kytövuori, Kari Majamaa   +3 more
wiley   +1 more source

Quantitative and Phylogenetic Analyses of Immature Neurons in Cortical Layer II and Amygdala of Macaque Monkeys. [PDF]

Cells
Pattaro A, Ghibaudi M, Bramel M, Sherwood CC, Bonfanti L.   +4 more
europepmc   +1 more source