Results 61 to 70 of about 2,682,293 (230)

The SVZ stem cell niche–components, functions, and in vitro modelling

Frontiers in Cell and Developmental Biology, 2023
Neocortical development depends on the intrinsic ability of neural stem and progenitor cells to proliferate and differentiate to generate the different kinds of neurons in the adult brain.
Nesil Eşiyok, Michael Heide
doaj   +1 more source

H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion. [PDF]

, 2021
Increase in the size of human neocortex―acquired in evolution―accounts for the unique cognitive capacity of humans. This expansion reflects the evolutionarily enhanced proliferative ability of basal progenitors (BPs), including the basal radial glia ...
Seong, R.H., Esgleas Izquierdo, M., Kovachev, E., Brand-Saberi, B., Sakib, M.S., Rosenbusch, J., Albert, M., Seong, R., Angelova, M., Tuoc, T., Kaurani, L., Nguyen, H.T., Minkov, R., Huttner, W.B., Kerimoglu, C., Abbas, E., Nguyen, H.P., Teichmann, U., Esgleas, M., Stoykova, A., Tonchev, A., Pham, L., Tonchev, A.B., Nguyen, H., Sokpor, G., Xie, Y., Sakib, M., Maricic, N., Staiger, J.F., Staiger, J., Ulmke, P.A., Capece, V., Fischer, A., Huttner, W., Michurina, A., Ulmke, P., Kerimoglu, Cemil, Sakib, M. Sadman, Abbas, Eman, Ulmke, Pauline Antonie, Pham, Linh, Tonchev, Anton B., Xie, Yuanbin, Kaurani, Lalit, Nguyen, Huong, Sokpor, Godwin, Tuoc, Tran, Joachim Rosenbusch, Anton B. Tonchev, Nenad Maricic, Alexandra Michurina, Miriam Esgleas, Andre Fischer, Ulrike Teichmann, Rho H. Seong, Cemil Kerimoglu, Lalit Kaurani, Huu Phuc Nguyen, Eman Abbas, Godwin Sokpor, Radoslav Minkov, Anastassia Stoykova, Vincenzo Capece, Huong Nguyen, Wieland B. Huttner, Linh Pham, Beate Brand-Saberi, Mareike Albert, Emil Kovachev, Jochen F. Staiger, Meglena Angelova, Pauline Antonie Ulmke, Tran Tuoc, Yuanbin Xie, M. Sadman Sakib   +74 more
core   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

The microcircuit concept applied to cortical evolution:from three-layer to six-layer cortex

Frontiers in Neuroanatomy, 2011
Understanding the principles of organization of the cerebral cortex requires insight into its evolutionary history. This has traditionally been the province of anatomists, but evidence regarding the microcircuit organization of different cortical areas ...
Gordon M Shepherd
doaj   +1 more source

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

Printing‐Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling

Advanced Science, EarlyView.
Extrusion‐based 3D printing of silicones and discrete electronic components are combined to create cortical implants for rodents that integrate thermal neuromodulation and electrical recording. Linked to an autonomous auxiliary driver unit, the system enables rapid, stable and localized hypothermia alongside ECoG recording.
Spencer Ryan Moore, Naomi King, Aruã Clayton Da Silva, Clare Howarth, Jason Berwick, Thomas E. Paterson, Ivan R. Minev   +6 more
wiley   +1 more source

Spread of epileptiform activity in the immature rat neocortex studied with voltage-sensitive dyes and laser scanning microscopy [PDF]

, 1994
1. Adult rats and rats with a postnatal age of 3-29 days (PN 3-29) were used for the preparation of in vitro slices of the frontal neocortex. Epileptiform activity was induced by bath application of the gamma-aminobutyric acid-A (GABAA) receptor ...
Rucker, F., Ten Bruggencate, Gerrit, Sutor, Bernd, Hablitz, John H.   +3 more
core   +2 more sources

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Oral Actinomyces Species Exposure is Associated with Anxiety‐Like Behavior, Mitochondrial Remodeling, and Altered GABAergic Pathways

Advanced Science, EarlyView.
Oral exposure to cannabis‐associated Actinomyces species, particularly A. meyeri, is associated with anxiety‐like behavior in mice in the absence of detectable bacterial translocation or overt systemic inflammation. These findings support a potential oral‐brain metabolic axis involving candidate metabolites such as arginine and argininosuccinate ...
Tabinda Salman, Zhenwu Luo, Douglas Johnson, Arshad A. Noorani, Zhuang Wan, Bogdan Bordieanu, Zhi‐wei Ye, Rachel D. Penrod, Hongxu Xian, Sylvia Fitting, Peter W. Kalivas, Wei Jiang   +11 more
wiley   +1 more source

Role of cell metabolism in the pathophysiology of brain size-associated neurodevelopmental disorders

Neurobiology of Disease
Cell metabolism is a key regulator of human neocortex development and evolution. Several lines of evidence indicate that alterations in neural stem/progenitor cell (NPC) metabolism lead to abnormal brain development, particularly brain size-associated ...
Lei Xing, Wieland B. Huttner, Takashi Namba   +2 more
doaj   +1 more source