Results 41 to 50 of about 178,038 (303)

Sequestration of noble gases in giant planet interiors

open access: yes, 2010
The Galileo probe showed that Jupiter's atmosphere is severely depleted in neon compared to protosolar values. We show, via ab initio simulations of the partitioning of neon between hydrogen and helium phases, that the observed depletion can be explained
Burkhard Militzer   +2 more
core   +1 more source

The contribution of Oxygen-Neon white dwarfs to the MACHO content of the Galactic Halo [PDF]

open access: yes, 2007
The interpretation of microlensing results towards the Large Magellanic Cloud (LMC) still remains controversial. White dwarfs have been proposed to explain these results and, hence, to contribute significantly to the mass budget of our Galaxy. However,
Adams   +45 more
core   +4 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Electronic spectra of linear HC$_5$H and cumulene carbene H$_2$C$_5$ [PDF]

open access: yes, 2015
The $1 ^3\Sigma_u^- \leftarrow X^3\Sigma_g^-$ transition of linear HC$_5$H (A) has been observed in a neon matrix and gas phase. The assignment is based on mass-selective experiments, extrapolation of previous results of the longer HC$_{2n+1}$H ...
Adam Nagy   +7 more
core   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

ON THE CHANGE OF THE SURFACE ENERGY UNDER THE ALL-ROUND COMPRESSION OR SPRAINING OF THE CRYSTAL [PDF]

open access: yesФизико-химические аспекты изучения кластеров, наноструктур и наноматериалов, 2011
Expressions for the dependencies of the specific surface energy σ and its isochoric derivative with respect to the temperature (∂σ/∂T)V versus of the relative volume V/V0 of the simple matter crystal are received.
M.N. Magomedov
doaj  

Factors affecting relative height and ground elevation estimations of GEDI among forest types across the conterminous USA

open access: yesGIScience & Remote Sensing, 2022
The Global Ecosystem Dynamics Investigation (GEDI), a new spaceborne LiDAR system of the National Aeronautics and Space Administration (NASA), has the potential to revolutionize global measurements of vertical vegetation structure.
Cangjiao Wang   +7 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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