Results 101 to 110 of about 4,213 (269)

Bioactive Compound Characterization and Phytopharmacological Potentials of Tulbaghia violacea Fruits and Seeds

Chemistry &Biodiversity, EarlyView.
Flow chat for the quantitative and qualitative profiles and the biological activities of T. violacea fruits and seeds. ABSTRACT Tulbaghia violacea is an established medicinal plant that is indigenous to southern Africa. All its plant parts have been profiled for their phytochemical constituents and medicinal potentials except for the seeds and fruits ...
Rebecca Opeyemi Oyerinde, Ida Masana Risenga   +1 more
wiley   +1 more source

Sepsis is a syndrome with hyperactivity of TH17-like innate immunity and hypoactivity of adaptive immunity [PDF]

arXiv, 2013
Currently, there are two major theories for the pathogenesis of sepsis: hyperimmune and hypoimmune. Hyperimmune theory suggests that cytokine storm causes the symptoms of sepsis. On the contrary, hypoimmune theory suggests that immunosuppression causes the manifestations of sepsis.
arxiv  

Engineering and Structural Elucidation of a Sac7d‐Derived IgG Fc‐Specific Affitin and Its Application for the Light‐Controlled Affinity Purification of Antibodies

ChemBioChem, EarlyView.
An affitin derived from the Sac7d scaffold enables the light‐controlled affinity purification of antibodies under physiological conditions, thus overcoming limitations of protein A chromatography. X‐ray crystallographic analysis and affinity measurements reveal complex formation with Fc at the CH2/CH3 junction, similar to protein A/G and FnRn. Combined
Felix Veitl, Andreas Eichinger, Peter Mayrhofer, Markus R. Anneser, Mauricio Testanera, Kilian Rauscher, Matthias Lenz, Arne Skerra   +7 more
wiley   +1 more source

Interactions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fcγ receptors and functional impact on immune cells in vitro

mAbs
Rozanolixizumab is a humanized anti-neonatal Fc receptor (FcRn) monoclonal antibody (mAb) of the immunoglobulin G4 (IgG4) sub-class, currently in clinical development for the treatment of IgG autoantibody-driven diseases.
Omar S. Qureshi, Emma J. Sutton, Rosemary F. Bithell, Shauna M. West, Rona M. Cutler, Gillian McCluskey, Graham Craggs, Asher Maroof, Nicholas M. Barnes, David P. Humphreys, Stephen Rapecki, Bryan J. Smith, Anthony Shock   +12 more
doaj   +1 more source

Optimizing Brentuximab Vedotin Dosing in Pediatric Patients with Advanced Hodgkin Lymphoma: A Population Pharmacokinetic and Exposure‐Response Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric patients with advanced‐stage newly diagnosed Hodgkin lymphoma (HL) were treated with brentuximab vedotin (BV) combined with adriamycin, vinblastine, and dacarbazine (A + AVD). Weight‐based BV dosing is employed in adult patients, while both body weight‐ and body surface area (BSA)‐based dosing are used in pediatric patients.
Xiaofei Zhou, Diane R. Mould, Lia Gore, Xiang Bai, Neeraj Gupta   +4 more
wiley   +1 more source

Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics

International Journal of Cell Biology, 2013
Transport of macromolecules across the blood-brain-barrier (BBB) requires both specific and nonspecific interactions between macromolecules and proteins/receptors expressed on the luminal and/or the abluminal surfaces of the brain capillary endothelial ...
Guangqing Xiao, Liang-Shang Gan
doaj   +1 more source

Metabolic changes during cardiac regeneration in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background The axolotl is a prominent model organism of heart regeneration due to its ability to anatomically and functionally repair the heart after an injury that mimics human myocardial infarction. In humans, such an injury leads to permanent scarring. Cardiac regeneration has been linked to metabolism and the oxygenation state, but so far,
Anita Dittrich, Sofie Amalie Andersson, Morten Busk, Kasper Hansen, Casper Bindzus Foldager, Johan Palmfeldt, Asger Andersen, Michael Pedersen, Mikkel Vendelbo, Kirstine Lykke Nielsen, Henrik Lauridsen   +10 more
wiley   +1 more source

Human FcRn can mediate the transport across intestinal mucosal barrier and prolong the half-life of rabbit IgG in vivo

Brazilian Archives of Biology and Technology, 2015
FcRn (neonatal Fc receptor) plays an important role in IgG transportation, antigen presentation and signal transmission. In this study, the complement fixation test and flow cytometry test were performed to verify whether the heterologous antibody could ...
Guangchang Pang, Yufang Wang, Junbo Xie, Qingsen Chen, Zhihe Hu   +4 more
doaj   +1 more source

Breast Milk Metabolomic Profile Is Associated With Maternal Overweight/Obesity Status or Adherence to Mediterranean Diet and Infant Weight Gain During the First Month of Lactation

Food Frontiers, EarlyView.
Maternal diet and overweight/obesity can affect breast milk metabolites and infant growth. ABSTRACT Breast milk provides a wide range of nutritional and bioactive components crucial for infant growth and development during lactation, ultimately influencing future health outcomes.
Catalina A. Pomar, Petr Zouhar, María DeLucas, Tomas Cajka, Pilar Cobo, María Victoria Jiménez‐Cabanillas, Pere Bibiloni, Jan Kopecky, Andreu Palou, Francisca Serra, Juana Sánchez, Catalina Picó   +11 more
wiley   +1 more source

Fructose promotes more than glucose the adipocytic differentiation of pig mesenchymal stem cells

Journal of Food Biochemistry, Volume 46, Issue 12, December 2022., 2022
This work show the effect of fructose on adipose differentiation. High levels of fructose increase the expansion of genes such as C/EBPβ, PPARγ, and NOX4 as well as the increase in XOR activity and high production of ROS during the differentiation process.
Francisco Campos‐Maldonado, María L. González‐Dávalos, Enrique Piña, Miriam Aracely Anaya‐Loyola, Armando Shimada, Alfredo Varela‐Echavarria, Ofelia Mora   +6 more
wiley   +1 more source