Results 121 to 130 of about 4,213 (269)

THE ROLE OF THE NEONATAL FC RECEPTOR IN THE UNCOATING OF ECHOVIRUSES AND COXSACKIEVIRUS A9

Problems of Virology, 2019
The aim of this study was to determine the role of the human neonatal receptor for the Fc fragment of IgG (hFcRn) as a common uncoating cellular receptor for echoviruses and coxsackievirus A9 during infection of human rhabdomyosarcoma (RD) cells. Material and methods.
A. V. Rezaykin, A.G. Sergeev, A.V. Novoselov, P. S. Usoltseva, A. V. Alimov   +4 more
openaire   +5 more sources

Integrative cross‐tissue analysis unveils complement‐immunoglobulin augmentation and dysbiosis‐related fatty acid metabolic remodeling during mammalian aging

iMeta, EarlyView.
Our study provides a comprehensive multi‐omics profile of aging, integrating proteomic, metabolomic, and metagenomic analyses across diverse tissues and plasma. We identified the synergistic amplification of the circulating complement system and tissue‐wide immunoglobulin accumulation as key molecular drivers of inflammaging.
Feng Zhang, Rong Li, Yasong Liu, Jinliang Liang, Yihang Gong, Cuicui Xiao, Jianye Cai, Tingting Wang, Qiang You, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Yingcai Zhang, Yang Yang, Hua Li, Jia Yao, Qi Zhang, Jun Zheng   +17 more
wiley   +1 more source

Cause-of-death estimates for the early and late neonatal periods for 194 countries from 2000-2013 [PDF]

arXiv, 2014
Objective: Cause-of-death distributions are important for prioritising interventions. We estimated proportions, risks, and numbers of deaths (with uncertainty) for programme-relevant causes of neonatal death for 194 countries for 2000-2013, differentiating between the early (days 0-6) and late (days 7-27) neonatal periods.
arxiv  

Automatic Coding for Neonatal Jaundice From Free Text Data Using Ensemble Methods [PDF]

arXiv, 2018
This study explores the creation of a machine learning model to automatically identify whether a Neonatal Intensive Care Unit (NICU) patient was diagnosed with neonatal jaundice during a particular hospitalization based on their associated clinical notes.
arxiv  

DEFECTIVE TARGET CELL ADHESION AND IgG Fc RECEPTOR (FcR)EXPRESSION ASSSOCIATED WITH LOW NEONATAL ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY (ADCC) TO HERPES SIMPLEX VIRUS (HSV) [PDF]

, 1984
Steve Kohl, L S Loo, Bernard Gonik
openalex   +1 more source

Registered trials on novel therapies for myasthenia gravis: a cross-sectional study on ClinicalTrials.gov

Scientific Reports
Novel biologics in MG therapy research is on the rise. This research aimed to investigate the characteristics of registered trials on novel therapies for myasthenia gravis on ClinicalTrials.gov.
Xingyue Li, Jinxin Chen, Youtao Wang, Siwei Zheng, Kun Wan, Xiaodong Liu   +5 more
doaj   +1 more source

Frequency of the polymorphonuclear neutrophil Fc gamma receptor III deficiency in the French population and its involvement in the development of neonatal alloimmune neutropenia [PDF]

, 1992
Patricia Fromont, Ali Bettaı̈eb, H Skouri, Corentin Le Floc’h, E Poulet, N. Duédari, P Bierling   +6 more
openalex   +1 more source

Effect of cystic fibrosis modulator therapies on serum levels of fat‐soluble vitamins

JPGN Reports, EarlyView.
Abstract This is a prospective, multicenter study of a cohort of 224 cystic fibrosis (CF) patients treated with CF transmembrane conductance regulator (CFTR) modulators (CFTRm). Our aim was to prospectively analyze the effect of CFTRm treatment on fat‐soluble vitamin serum levels.
Elena Crehuá‐Gaudiza, Saioa Vicente Santamaría, Marina Álvarez Beltrán, Carmen Martín Fernández, Carlos Tutau Gómez, Inés Loverdos Eseverri, Ruth García Romero, Encarni Torcuato Rubio, Rodrigo Del Brío Castillo, María Garriga García, Celia Gascón Galindo, José Ramón Gutiérrez Martínez, Ana María Castro Millán, Sara Sierra San Nicolás, Pilar Ortiz Pérez, Camila García Volpe, Enrique Salcedo Lobato, Agustín De La Mano Hernández, Sara María Fernández González, Ana Reyes Domínguez, Luis Peña‐Quintana, David González Jiménez, Cystic Fibrosis and Pancreas Working Group of the Spanish Gastroenterology, Hepatology and Nutrition Paediatric Society (SEGHNP)   +23 more
wiley   +1 more source

Harnessing Open‐Source Solutions: Insights From the First Open Systems Pharmacology (OSP) Community Conference

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT In 2017, the free and open‐source software Open Systems Pharmacology (OSP) was launched. Since then, OSP has evolved from a small community into a diverse network of stakeholders committed to advancing open‐source solutions for model‐informed drug development (MIDD). In this context, the first OSP Community Conference was hosted by Novartis in
André Dallmann, Denise Feick, Pavel Balazki, Salih Benamara, Rolf Burghaus, Marylore Chenel, Siak‐Leng Choi, Henrik Cordes, Mariana Guimarães, Abdullah Hamadeh, Ibrahim Ince, Kathleen M. Job, Tobias Kanacher, Andreas Kovar, Lars Kuepfer, Jörg Lippert, Julia Macente, Nina Nauwelaerts, Christoph Niederalt, Sheila Peters, Susana Proença, Masanobu Sato, Stephan Schaller, Jan Frederik Schlender, Annika Schneider, Erik Sjögren, Juri Solodenko, Alexander Staab, Paul Vrenken, Thomas Wendl, Wilhelmus E. A. de Witte, Donato Teutonico   +31 more
wiley   +1 more source

Structure and dynamics of dynorphin peptide and its receptor [PDF]

arXiv, 2019
Dynorphin is a neuropeptide involved in pain, addiction and mood regulation. It exerts its activity by binding to the kappa opioid receptor (KOP) which belongs to the large family of G-protein coupled receptors. The dynorphin peptide was discovered in 1975, while its receptor was cloned in 1993.
arxiv