Results 131 to 140 of about 4,213 (269)

Pterostilbene Exhibits Broad‐Spectrum Antiviral Activity by Targeting the Enterovirus Capsid, Inactivating Viral Particles, Blocking Viral Binding, and Protecting Mice From Lethal EV‐A71 Challenge

Phytotherapy Research, EarlyView.
Pterostilbene (Pte) binds to the VP1 hydrophobic pocket of enteroviruses, stabilizing the viral capsid and preventing uncoating and RNA release. In vitro, Pte inactivates virions and impairs viral attachment, entry, and replication. In vivo, oral administration of Pte in hSCARB2‐transgenic mice reduces clinical symptoms and improves survival ...
Kuan‐Ting Chuang, Siao‐Cian Pan, Bor‐Luen Chiang, Shih‐Hsun Chen, Min‐Hsiung Pan, Yu‐Li Chen, Cheng‐Sheng Lin, Chun‐Kai Pan, Jing‐Yi Lin, Yu‐Li Lin   +9 more
wiley   +1 more source

Oral and pulmonary delivery of FSH–Fc fusion proteins via neonatal Fc receptor-mediated transcytosis [PDF]

, 2005
S C Low, S.L. Nunes, Alan J. Bitonti, Jennifer Dumont   +3 more
openalex   +1 more source

Understanding the Mechanism of Cardiotoxicity Induced by Nanomaterials: A Comprehensive Review

Small Science, EarlyView.
This review provides a bibliometric analysis for understanding the study of nanotoxicity on cardiovascular health. It begins by outlining the pathways through which nanomaterials enter the cardiovascular system, followed by a summary of the mechanisms underlying nanomaterial‐induced cardiotoxicity.
Zaiyong Zheng, Shuang Zhu, Xiaobo Wang, Haoran Wu, Min Fu, Houxiang Hu, Zhanjun Gu, Chunxiang Zhang   +7 more
wiley   +1 more source

Experimental and Computational Insights into the Structural Dynamics of the Fc Fragment of IgG1 Subtype from Biosimilar VEGF‐Trap

Small Structures, EarlyView.
The constant fragment (Fc) of the immunoglobulin G1 (IgG1) subtype is a widely used scaffold for designing advanced therapeutics. Herein, together with the integration of experimental and computational techniques, this study reveals the structural dynamics of the N‐glycan‐bound Fc fragment of IgG1 from VEGF‐Trap, providing a new insight into enhancing ...
Ebru Destan, Engin Turkut, Alper Aldeniz, Jungmin Kang, Takehiko Tosha, Makina Yabashi, Baris Yilmaz, Ahmet Can Timucin, Hiroaki Matsuura, Yoshiaki Kawano, Irfan Cinkaya, Hasan DeMirci   +11 more
wiley   +1 more source

A Single Channel-Based Neonatal Sleep-Wake Classification using Hjorth Parameters and Improved Gradient Boosting [PDF]

arXiv
Sleep plays a crucial role in neonatal development. Monitoring the sleep patterns in neonates in a Neonatal Intensive Care Unit (NICU) is imperative for understanding the maturation process. While polysomnography (PSG) is considered the best practice for sleep classification, its expense and reliance on human annotation pose challenges.
arxiv  

Acute Respiratory Distress Syndrome is a TH17-like and Treg immune disease [PDF]

arXiv, 2013
Acute Respiratory Distress Syndrome (ARDS) is a very severe syndrome leading to respiratory failure and subsequent mortality. Sepsis is one of the leading causes of ARDS. Thus, extracellular bacteria play an important role in the pathophysiology of ARDS. Overactivated neutrophils are the major effector cells in ARDS.
arxiv  

Maternal Antibodies Enhance or Prevent Cytomegalovirus Infection in the Placenta by Neonatal Fc Receptor-Mediated Transcytosis [PDF]

, 2006
Ekaterina Maidji, Susan McDonagh, Olga Genbačev, Takako Tabata, Lenore Pereira   +4 more
openalex   +1 more source

First‐Trimester Prediction of Gestational Diabetes Mellitus Based on Maternal Risk Factors

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To develop and validate a new first‐trimester model for the prediction of gestational diabetes mellitus (GDM) based on maternal demographic characteristics and elements of medical history. Design Prospective cohort study. Setting Inner‐city hospital.
Argyro Syngelaki, Alan Wright, Cristina Gomez Fernandez, Rea Mitsigiorgi, Kypros H. Nicolaides   +4 more
wiley   +1 more source

Case report: Rapid symptom relief in autoimmune encephalitis with efgartigimod: a three-patient case series

Frontiers in Immunology
IntroductionAutoimmune encephalitis (AE) comprises a group of inflammatory brain disorders mediated by autoimmune responses. Anti–N-methyl-D-aspartate receptor (NMDAR) encephalitis, anti–leucine-rich glioma-inactivated 1 (LGI1) encephalitis, and anti–γ ...
Qianqian Zhang, Wenping Yang, Yun Qian, Yu Zhang, Huihui Zhao, Mingzhu Shu, Qingyang Li, Yanan Li, Yu Ding, Shiyu Shi, Yaxi Liu, Xi Cheng, Qi Niu   +12 more
doaj   +1 more source

Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria [PDF]

, 2006
Masayuki Yoshida
openalex   +1 more source