Results 11 to 20 of about 4,213 (269)

The Neonatal Fc Receptor (FcRn): A Misnomer? [PDF]

Frontiers in Immunology, 2019
Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids.
Michal Pyzik, Kine M. K. Sand, Kine M. K. Sand, Jonathan J. Hubbard, Jonathan J. Hubbard, Jan Terje Andersen, Jan Terje Andersen, Inger Sandlie, Richard S. Blumberg, Richard S. Blumberg   +9 more
doaj   +6 more sources

The neonatal Fc receptor in cancer FcRn in cancer [PDF]

Cancer Medicine, 2020
Since the neonatal IgG Fc receptor (FcRn) was discovered, it was found to be involved in immunoglobulin recycling and biodistribution, immune complexes routing, antigen presentation, humoral immune response, and cancer immunosurveillance. The latest data
Diana Cadena Castaneda, Guillaume Brachet, Caroline Goupille, Lobna Ouldamer, Valérie Gouilleux‐Gruart   +4 more
doaj   +4 more sources

The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor

Nature Communications
Arteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide CRISPR ...
Teressa M. Shaw, Devra Huey, Makky Mousa-Makky, Jared Compaleo, Kylie Nennig, Aadit P. Shah, Fei Jiang, Xueer Qiu, Devon Klipsic, Raymond R. R. Rowland, Igor I. Slukvin, Meagan E. Sullender, Megan T. Baldridge, Haichang Li, Cody J. Warren, Adam L. Bailey   +15 more
doaj   +3 more sources

Antagonism of the Neonatal Fc Receptor as an Emerging Treatment for Myasthenia Gravis [PDF]

Frontiers in Immunology, 2020
Myasthenia gravis is an autoimmune disease in which immunoglobulin G (IgG) autoantibodies are formed against the nicotinic acetylcholine receptor (AChR) or other components of the neuromuscular junction.
Karissa L. Gable, Jeffrey T. Guptill, Jeffrey T. Guptill   +2 more
doaj   +4 more sources

The neonatal Fc receptor in mucosal immune regulation [PDF]

Scandinavian Journal of Immunology, 2020
AbstractThe neonatal Fc receptor (FcRn) was first recognized for its role in transfer of maternal IgG to the foetus or newborn, providing passive immunity early in life. However, it has become clear that the receptor is versatile, widely expressed and plays an indispensable role in both immunological and non‐immunological processes throughout life. The
Kristin Hovden Aaen, Aina Anthi, Inger Sandlie, Jeannette Nilsen, Simone Mester, Jan Terje Andersen   +5 more
openalex   +4 more sources

Characterization of basolateral-targeting signals in the neonatal Fc receptor [PDF]

Journal of Cell Science, 2005
The neonatal Fc receptor, FcRn, transports proteins through cells, avoiding degradative compartments. FcRn is used in many physiological processes where proteins must remain intact while they move through cells. These contexts include the transport of IgG antibodies from mother to offspring, and the protection of IgG and albumin from catabolism.
Estelle E. Newton, Zhenping Wu, Neil E. Simister   +2 more
openalex   +4 more sources

Computational determination of the structure of rat fc bound to the neonatal fc receptor

Journal of Molecular Biology, 1998
The available crystal structure for the complex between the Fc fragment of immunoglobulin G (IgG) and the neonatal Fc receptor (FcRn) was determined at low resolution and has no electron density for a large portion of the CH2 domain of the Fc. Here, we use a well validated computational docking algorithm in conjunction with known crystallographic data ...
Zhiping Weng, Kamalakar Gulukota, Daniel E. Vaughn, Pamela J. Björkman, Charles DeLisi   +4 more
openalex   +5 more sources

The neonatal Fc receptor is expressed by human lymphocytes [PDF]

Journal of Translational Medicine, 2010
The neonatal Fc receptor (FcRn) is an MHC class I like receptor that binds immunoglobulin G (IgG) in acidic environment (mainly endosomes). The FcRn protects IgG from lysosomal degradation, controls its transport between cell layers and extends IgG serum half-life [1].
De Haas E F, Dik W A, Bastiaans J, van Bilsen K, Baarsma S G, Kuipers R W, van Hagen P M   +6 more
doaj   +3 more sources

The neonatal Fc receptor is a pan-echovirus receptor [PDF]

Proceedings of the National Academy of Sciences, 2019
SignificanceEchoviruses are associated with aseptic meningitis and induce severe and sometimes fatal disease in neonates and young infants. Here, we identify the neonatal Fc receptor (FcRn) as a pan-echovirus receptor. FcRn is expressed on the surface of the human placenta, and throughout life on intestinal enterocytes, liver hepatocytes, and in the ...
Stefanie Morosky, Alexandra I. Wells, Kathryn Lemon, Azia S. Evans, Sandra Schamus, Christopher J. Bakkenist, Carolyn B. Coyne   +6 more
openaire   +4 more sources

Neonatal Fc Receptor–Targeted Therapies in Neurology [PDF]

Neurotherapeutics, 2022
Autoantibodies are increasingly recognized for their pathogenic potential in a growing number of neurological diseases. While myasthenia gravis represents the prototypic antibody (Ab)-mediated neurological disease, many more disorders characterized by Abs targeting neuronal or glial antigens have been identified over the past two decades.
Nelke, Christopher, Spatola, Marianna, Schroeter, Christina B., Wiendl, Heinz, Lünemann, Jan D.   +4 more
openaire   +2 more sources