Neonatal Fc Receptor-Targeted Therapies in Neurology. [PDF]
Neurotherapeutics, 2022 Autoantibodies are increasingly recognized for their pathogenic potential in a growing number of neurological diseases. While myasthenia gravis represents the prototypic antibody (Ab)-mediated neurological disease, many more disorders characterized by ...
Nelke C +4 more
europepmc +5 more sources
Expression of Neonatal Fc Receptor in the Eye [PDF]
Investigative Opthalmology & Visual Science, 2014 PURPOSE: The neonatal Fc receptor (FcRn) plays a critical role in the homeostasis and degradation of immunoglobulin G (IgG). It mediates the transport of IgG across epithelial cell barriers and recycles IgG in endothelial cells back into the bloodstream.
Michael B. Powner +4 more
core +7 more sources
The neonatal Fc receptor in cancer FcRn in cancer [PDF]
Cancer Medicine, 2020 Since the neonatal IgG Fc receptor (FcRn) was discovered, it was found to be involved in immunoglobulin recycling and biodistribution, immune complexes routing, antigen presentation, humoral immune response, and cancer immunosurveillance. The latest data
Diana Cadena Castaneda +4 more
doaj +5 more sources
The neonatal Fc receptor is a cellular receptor for human astrovirus. [PDF]
Nat MicrobiolHuman astroviruses (HAstV) are major causes of gastroenteritis, especially in children, and there are no vaccines or antivirals currently available. Little is known about host factors required for their cellular entry. Here we utilized complementary CRISPR-Cas9-based knockout and activation screens to identify neonatal Fc receptor (FcRn) and dipeptidyl-
Ingle H +11 more
europepmc +4 more sources
Targeting the neonatal Fc receptor in pemphigus: safety first. [PDF]
Br J Dermatol, 2022 Micevic G, Lo SN, Rajan N.
europepmc +6 more sources
Targeting the Neonatal Fc Receptor in Autoimmune Diseases: Pipeline and Progress. [PDF]
BioDrugsAutoimmune diseases are highly prevalent and affect people at all ages, women more often than men. The most prominent immunological manifestation is the production of antibodies directed against self-antigens.
Gjølberg TT +5 more
europepmc +2 more sources
Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes [PDF]
Frontiers in Immunology, 2021 Tolerogenic vaccinations using beta-cell antigens are attractive for type 1 diabetes prevention, but clinical trials have been disappointing. This is probably due to the late timing of intervention, when multiple auto-antibodies are already present.
Noémie Corcos +6 more
doaj +2 more sources
“Ways in which the neonatal Fc-receptor is involved in autoimmunity” [PDF]
Journal of Translational Autoimmunity, 2021 Since the neonatal IgG Fc receptor (FcRn) was discovered, its role has evolved from immunoglobulin recycling and biodistribution to antigen presentation and immune complex routing, bringing it to the center of both humoral and cellular immune responses ...
Juliette Lamamy +5 more
doaj +2 more sources
Functionalized zein nanoparticles targeting neonatal Fc receptor to enhance lung absorption of peptides. [PDF]
Drug Deliv Transl Res, 2023 Peptides have a distinguished therapeutic potential for several chronic conditions, and more than 80 peptides exist in the global market. However, most of these marketed peptide drugs are currently delivered intravenously or subcutaneously due to their ...
Hameedat F +4 more
europepmc +2 more sources
Neonatal Fc receptor promoter gene polymorphism does not predict pharmacokinetics of
, 2016 Treatment of Guillain-Barré syndrome with a standard course of high-dose intravenous immunoglobulin (IVIg) results in a variable clinical recovery which is associated with changes in serum IgG levels after treatment. The neonatal Fc-receptor protects IgG
Willem‐Jan R. Fokkink +6 more
openalex +4 more sources