Results 41 to 50 of about 4,213 (269)

ENPP1 deficiency: A clinical update on the relevance of individual variants using a locus‐specific patient database

Human Mutation, Volume 43, Issue 12, Page 1673-1705, December 2022., 2022
Abstract Loss‐of‐function variants in the ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) cause ENPP1 Deficiency, a rare disorder characterized by pathological calcification, neointimal proliferation, and impaired bone mineralization. The consequence of ENPP1 Deficiency is a broad range of age dependent symptoms and morbidities
Stephanie A. Mercurio, Lauren M. Chunn, Gus Khursigara, Catherine Nester, Kathleen Wray, Ulrike Botschen, Mark J. Kiel, Frank Rutsch, Carlos R. Ferreira   +8 more
wiley   +1 more source

Modifying antibody-FcRn interactions to increase the transport of antibodies through the blood-brain barrier

mAbs, 2023
The blood-brain barrier (BBB) largely excludes antibodies from entering the central nervous system, thus limiting the potential of therapeutic antibodies to treat conditions such as neurodegenerative diseases and neuro-psychiatric disorders.
Jason Tien, Dmitri Leonoudakis, Ralitsa Petrova, Vivian Trinh, Tetsuya Taura, Debapriya Sengupta, Lisa Jo, Angela Sho, Yong Yun, Eric Doan, Anita Jamin, Hussein Hallak, David S. Wilson, Jennifer R. Stratton   +13 more
doaj   +1 more source

Neonatal Bowel Sound Detection Using Convolutional Neural Network and Laplace Hidden Semi-Markov Model [PDF]

IEEE/ACM Transactions on Audio, Speech, and Language Processing, 2022, 2021
Abdominal auscultation is a convenient, safe and inexpensive method to assess bowel conditions, which is essential in neonatal care. It helps early detection of neonatal bowel dysfunctions and allows timely intervention. This paper presents a neonatal bowel sound detection method to assist the auscultation. Specifically, a Convolutional Neural Network (
arxiv   +1 more source

First‐trimester screening for pre‐eclampsia and small for gestational age: A comparison of the gaussian and Fetal Medicine Foundation algorithms

International Journal of Gynecology &Obstetrics, Volume 160, Issue 1, Page 150-160, January 2023., 2023
Abstract Objective Pre‐eclampsia (PE) and small for gestational age (SGA) can be predicted from the first trimester. The most widely used algorithm worldwide is the Fetal Medicine Foundation (FMF) algorithm. The recently described Gaussian algorithm has reported excellent results although it is unlikely to be externally validated.
Berta Serrano, Erika Bonacina, Carlota Rodo, Pablo Garcia‐Manau, María Ángeles Sanchez‐Duran, María Pancorbo, Cristina Forcada, María Teresa Murcia, Ana Perestelo, Mireia Armengol‐Alsina, Manel Mendoza, Elena Carreras   +11 more
wiley   +1 more source

Neonatal Fc receptor is involved in the protection of fibrinogen after its intake in peripheral blood mononuclear cells

Journal of Translational Medicine, 2018
Background Fibrinogen is a central player in the blood coagulation cascade and one of the most abundant plasma proteins. This glycoprotein also triggers important events (e.g., cell spreading, the respiratory burst and degranulation) in neutrophil cells ...
Tiziana Alberio, Greta Forlani, Marta Lualdi, Giovanna Tosi, Roberto S. Accolla, Mauro Fasano   +5 more
doaj   +1 more source

An Intuitive Automated Modelling Interface for Systems Biology [PDF]

EPTCS 9, 2009, pp. 73-86, 2009
We introduce a natural language interface for building stochastic pi calculus models of biological systems. In this language, complex constructs describing biochemical events are built from basic primitives of association, dissociation and transformation.
arxiv   +1 more source

Characterization and screening of IgG binding to the neonatal Fc receptor [PDF]

mAbs, 2014
The neonatal Fc receptor (FcRn) protects immunoglobulin G (IgG) from degradation and increases the serum half-life of IgG, thereby contributing to a higher concentration of IgG in the serum. Because altered FcRn binding may result in a reduced or prolonged half-life of IgG molecules, it is advisable to characterize Fc receptor binding of therapeutic ...
Mechthild Linnemann, Jan Jaehrling, Katrin Frese, Stefan Pabst, Anne Höhne, Ralf Ostendorp, Bodo Brocks, Thomas Tiller, Karin Felderer, Stefan Kaden, Sebastian Jäger, Tobias Neuber, Johanna Kölln, Daniela Daubert   +13 more
openaire   +3 more sources

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice

Cell Reports, 2015
Immunoglobulin G (IgG) antibodies are major drivers of autoimmune pathology, but they are also used in the form of intravenous IgG (IVIg) therapy to suppress autoantibody activity. To identify the pathways underlying human autoantibody and IVIg activity,
Inessa Schwab, Anja Lux, Falk Nimmerjahn
doaj   +1 more source

Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering

mAbs, 2022
A conventional antibody targeting a soluble antigen in circulation typically requires a huge dosage and frequent intravenous administration to neutralize the antigen.
Yuji Hori, Ken Ohmine, Hitoshi Katada, Yuki Noguchi, Kazuki Sato, Takeru Nambu, Lam Runyi Adeline, Gan Siok Wan, Kenta Haraya, Kazuhisa Ozeki, Masahiko Nanami, Tatsuhiko Tachibana, Zenjiro Sampei, Taichi Kuramochi, Junichi Nezu, Kunihiro Hattori, Tomoyuki Igawa   +16 more
doaj   +1 more source

Unresolved excess accumulation of myelin-derived cholesterol contributes to scar formation after spinal cord injury [PDF]

arXiv, 2022
Background: Spinal cord injury triggers complex pathological cascades, resulting in destructive tissue damage and incomplete tissue repair. Scar formation is generally considered as a barrier for regeneration in central nervous system (CNS), while the intrinsic mechanism of scar-forming after spinal cord injury has not been completed deciphered ...
arxiv