Results 41 to 50 of about 19,143 (231)

Delanzomib, a Novel Proteasome Inhibitor, Combined With Adalimumab Drastically Ameliorates Collagen-Induced Arthritis in Rats by Improving and Prolonging the Anti-TNF-α Effect of Adalimumab

Frontiers in Pharmacology, 2021
Delanzomib is a novel proteasome inhibitor initially developed for treating multiple myeloma. It was found to inhibit the expression of tumor necrosis factor alpha (TNF-α). This study aimed to investigate the ameliorating effect of delanzomib on collagen-
Lei Wang, Lei Wang, Lixiong Liu, Xiaoping Hong, Dongzhou Liu, Zeneng Cheng   +5 more
doaj   +1 more source

Guided Bone Regeneration Membrane Materials Loaded with Chimeric Nanovesicles Promote Early Bone Defect Regeneration

Advanced Healthcare Materials, EarlyView.
Early bone regeneration is challenged by poor osteogenic microenvironments. We developed a novel guided bone regeneration (GBR) membrane: a plasma‐treated polycaprolactone (PT‐PCL) electrospun nanofiber functionalized with ultrasound sequentially extruded stromal vascular fraction chimeric vesicles (USE‐SCNVs). USE‐SCNVs require less equipment, enhance
Yufan Zhang, Yaqiong Wang, Xiaona Ning, Guichu Yue, Wenhui Zhang, Yicheng Chen, Xuelian Jia, Yu Zhang, Xiao Zhang, Zihan Lu, Simin Zhu, Fuwei Liu, Yong Zhao, Liang Kong   +13 more
wiley   +1 more source

Hydrocolloid‐Based Multiwavelength Stretchable QD‐OLED Patch for Simultaneous Neonatal Jaundice and Dermatitis Treatment with Biosignal Monitoring

Advanced Healthcare Materials, EarlyView.
Comparison of therapeutic and diagnostic applications of a surface‐emitting light source with multiwavelength emission characteristics. Abstract Conventional light‐emitting‐diode‐based light sources suffer from rigidity, localized heating, and poor adaptability to skin deformation, limiting their use in skin‐attached medical devices.
In Ho Kim, Young Woo Kim, Jae‐Young Jeong, Ye Ji Shin, Chaeyeong Lee, Jae Gyun Choi, Oh Kwan Kwon, Kyoung Hwa Kim, Sang Jik Kwon, Eou‐Sik Cho, Yongmin Jeon   +10 more
wiley   +1 more source

IgG subclasses and allotypes: from structure to effector functions

Frontiers in Immunology, 2014
Of the five immunoglobulin isotypes, Immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3 and IgG4 which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains ...
Gestur eVidarsson, Gillian eDekkers, Theo eRispens   +2 more
doaj   +1 more source

To determine the genotyping of Fc-gamma receptor FCGR2A polymorphism as genetic susceptibility to neonatal sepsis: A study from a tertiary center of North India

Journal of Indian Association of Pediatric Surgeons, 2022
Background: Neonatal sepsis term is an infection of newborns
Sarita Chowdhary, Kanika Sharma, Ashish Ashish, Abhay Kumar Yadav, Pranay Panigrahi, Akas Mishra, Deepak Kumar, Royana Singh   +7 more
doaj   +1 more source

Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems

Advanced Therapeutics, EarlyView.
This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli, Lucas Silva Rodrigues, Maria Clara Moura Pinheiro, Sylvia Barbosa Pinhate, Marcelo de Macedo Brígido, Andréa Queiroz Maranhão   +5 more
wiley   +1 more source

Injectable BMSC‐Based Extracellular Matrix‐Mimicking Microtissue for Myocardial Infarction Repair

Advanced Science, EarlyView.
A novel injectable biomimetic extracellular matrix scaffold (JLSV) is designed for enhanced delivery of bone marrow‐derived mesenchymal stem cells (BMSCs). By utilizing janus basic nanotubes, laminin, stromal‐derived factor‐1 alpha, and vascular endothelial growth factor, this innovative JLSV–BMSC microtissue shows promise in myocardial infarction ...
Lina Yao, Huailong An, Cong Fan, Qingsu Lan, Hongyu Zhong, Yun Zhang, Libo Zhou, Panpan Hao   +7 more
wiley   +1 more source

Human cytomegalovirus evades antibody-mediated immunity through endoplasmic reticulum-associated degradation of the FcRn receptor

Nature Communications, 2019
Human cytomegalovirus (HCMV) can persist for the life of a host in the face of robust immune responses owing to a wide range of immune evasion strategies.
Xiaoyang Liu, Senthilkumar Palaniyandi, Iowis Zhu, Jin Tang, Weizhong Li, Xiaoling Wu, Susan Park Ochsner, C. David Pauza, Jeffrey I. Cohen, Xiaoping Zhu   +9 more
doaj   +1 more source

An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission

Nature Communications, 2023
SARS-CoV-2 is primarily transmitted through droplets and airborne aerosols, and in order to prevent infection and reduce viral spread vaccines should elicit protective immunity in the airways.
Weizhong Li, Tao Wang, Arunraj M. Rajendrakumar, Gyanada Acharya, Zizhen Miao, Berin P. Varghese, Hailiang Yu, Bibek Dhakal, Tanya LeRoith, Athira Karunakaran, Wenbin Tuo, Xiaoping Zhu   +11 more
doaj   +1 more source

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, EarlyView.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source