Results 61 to 70 of about 4,213 (269)

Delanzomib, a Novel Proteasome Inhibitor, Combined With Adalimumab Drastically Ameliorates Collagen-Induced Arthritis in Rats by Improving and Prolonging the Anti-TNF-α Effect of Adalimumab

Frontiers in Pharmacology, 2021
Delanzomib is a novel proteasome inhibitor initially developed for treating multiple myeloma. It was found to inhibit the expression of tumor necrosis factor alpha (TNF-α). This study aimed to investigate the ameliorating effect of delanzomib on collagen-
Lei Wang, Lei Wang, Lixiong Liu, Xiaoping Hong, Dongzhou Liu, Zeneng Cheng   +5 more
doaj   +1 more source

Activation of the JNK/MAPK Signaling Pathway by TGF-β1 Enhances Neonatal Fc Receptor Expression and IgG Transcytosis

Microorganisms, 2021
The neonatal Fc receptor (FcRn) transports maternal immunoglobulin G (IgG) to the foetus or newborn and protects the IgG from degradation. FcRn is expressed in several porcine tissues and cell types and its expression levels are regulated by immune and ...
Shaoju Qian, Chenxi Li, Xi Liu, Xiangchao Jia, Yuncai Xiao, Zili Li   +5 more
doaj   +1 more source

Transepithelial Transport of Fc-Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery [PDF]

Science Translational Medicine, 2013
Nanoparticles targeted to the neonatal Fc receptor cross the intestinal epithelium and reach systemic circulation after oral administration.
Etgar Levy-Nissenbaum, Etgar Levy-Nissenbaum, Robert Langer, Robert Langer, Omid C. Farokhzad, Omid C. Farokhzad, Frank Alexis, Frank Alexis, Timothy Kuo, Rohit Karnik, Eric M. Pridgen, Richard S. Blumberg   +11 more
openaire   +5 more sources

Predicting Adverse Neonatal Outcomes for Preterm Neonates with Multi-Task Learning [PDF]

arXiv, 2023
Diagnosis of adverse neonatal outcomes is crucial for preterm survival since it enables doctors to provide timely treatment. Machine learning (ML) algorithms have been demonstrated to be effective in predicting adverse neonatal outcomes. However, most previous ML-based methods have only focused on predicting a single outcome, ignoring the potential ...
arxiv  

Neonatal Fc Receptor Blockade by Fc Engineering Ameliorates Arthritis in a Murine Model [PDF]

The Journal of Immunology, 2011
Abstract Multiple autoimmune diseases are characterized by the involvement of autoreactive Abs in pathogenesis. Problems associated with existing therapeutics such as the delivery of intravenous immunoglobulin have led to interest in developing alternative approaches using recombinant or synthetic methods. Toward this aim, in the current
Alberto Puig-Canto, Dilip K. Challa, Raimund J. Ober, Raimund J. Ober, E. Sally Ward, Dipesh A. Patel, Héctor Perez Montoyo   +6 more
openaire   +4 more sources

Targeting the Neonatal Fc Receptor for Antigen Delivery Using Engineered Fc Fragments [PDF]

The Journal of Immunology, 2008
AbstractThe development of approaches for Ag delivery to the appropriate subcellular compartments of APCs and the optimization of Ag persistence are both of central relevance for the induction of protective immunity or tolerance. The expression of the neonatal Fc receptor, FcRn, in APCs and its localization to the endosomal system suggest that it might
Mi, Wentao, Wanjie, Sylvia, Lo, Su Tang, Gan, Zhuo, Pickl-Herk, Beatrix, Ober, Raimund J., Ward, E. Sally   +6 more
openaire   +2 more sources

Characterization of pig skeletal muscle transcriptomes in response to low temperature

Veterinary Medicine and Science, Volume 9, Issue 1, Page 181-190, January 2023., 2023
Low temperature changes the gene expression pattern and biological pathway in pig skeletal muscle. Under low temperature, biological pathways of lipid, amino acid, and carbohydrate metabolism; signal transduction; endocrine, immune, and nervous system; cardiovascular disease; infectious diseases caused by bacteria or viruses; and neurodegenerative ...
DongJie Zhang, Liang Wang, ShouZheng Ma, Hong Ma, Di Liu   +4 more
wiley   +1 more source

Neonatal Fc Receptor Mediates Internalization of Fc in Transfected Human Endothelial Cells [PDF]

Molecular Biology of the Cell, 2008
The neonatal Fc receptor, FcRn mediates an endocytic salvage pathway that prevents degradation of IgG, thus contributing to the homeostasis of circulating IgG. Based on the low affinity of IgG for FcRn at neutral pH, internalization of IgG by endothelial cells is generally believed to occur via fluid-phase endocytosis.
Victor J. Wroblewski, Nancy Goebl, Clifford M. Babbey, Derrick R. Witcher, Kenneth W. Dunn, Amita Datta-Mannan   +5 more
openaire   +3 more sources

Analysis of the longitudinal behavior of serum levels of Soluble Flt‐1 and Placental Growth Factor in pregnant women with Systemic Lupus Erythematosus

Arthritis Care &Research, Accepted Article.
Objective This study analyzed longitudinal trajectories of soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF) and sFlt‐1/PlGF ratio in a cohort of pregnant patients with systemic lupus erythematosus (SLE). Methods Blood samples were collected (14‐18, 24‐26, 30‐32, 34‐36 and 38‐40 weeks), stored at ‐80°C and evaluated for ...
Nilson R. de Jesús, Guilherme R. de Jesús, Marcela I. Lacerda, Flávia C. dos Santos, Jeane de S. Nogueira, Luiz Cristóvão Porto, Evandro S. F. Coutinho, Evandro M. Klumb   +7 more
wiley   +1 more source

To determine the genotyping of Fc-gamma receptor FCGR2A polymorphism as genetic susceptibility to neonatal sepsis: A study from a tertiary center of North India

Journal of Indian Association of Pediatric Surgeons, 2022
Background: Neonatal sepsis term is an infection of newborns
Sarita Chowdhary, Kanika Sharma, Ashish Ashish, Abhay Kumar Yadav, Pranay Panigrahi, Akas Mishra, Deepak Kumar, Royana Singh   +7 more
doaj   +1 more source