Results 71 to 80 of about 109,700 (295)

Neonatal Fc receptor is involved in the protection of fibrinogen after its intake in peripheral blood mononuclear cells

Journal of Translational Medicine, 2018
Background Fibrinogen is a central player in the blood coagulation cascade and one of the most abundant plasma proteins. This glycoprotein also triggers important events (e.g., cell spreading, the respiratory burst and degranulation) in neutrophil cells ...
Tiziana Alberio, Greta Forlani, Marta Lualdi, Giovanna Tosi, Roberto S. Accolla, Mauro Fasano   +5 more
doaj   +1 more source

Porcine Epidemic Diarrhea Virus nsp13 Protein Downregulates Neonatal Fc Receptor Expression by Causing Promoter Hypermethylation through the NF-κB Signaling Pathway.

Journal of Immunology, 2023
Porcine epidemic diarrhea virus (PEDV) is a highly pathogenic porcine enteric coronavirus that causes severe watery diarrhea and even death in piglets. The neonatal Fc receptor (FcRn) is the only transport receptor for IgG.
X. Jia, J. Chen, Chenyuan Qiao, Chenxi Li, Kang Yang, Yang Zhang, Jian Li, Zili Li   +7 more
semanticscholar   +1 more source

Selection of Nanobodies that Target Human Neonatal Fc Receptor [PDF]

Scientific Reports, 2013
FcRn is a key player in several immunological and non-immunological processes, as it mediates maternal-fetal transfer of IgG, regulates the serum persistence of IgG and albumin, and transports both ligands between different cellular compartments. In addition, FcRn enhances antigen presentation.
Andersen, Jan Terje, Gonzalez-Pajuelo, Maria, Foss, Stian, Landsverk, Ole J. B., Pinto, Debora, Szyroki, Alexander, de Haard, Hans J., Saunders, Michael, Vanlandschoot, Peter, Sandlie, Inger   +9 more
openaire   +3 more sources

Neonatal Fc Receptor Promotes Immune Complex–Mediated Glomerular Disease [PDF]

Journal of the American Society of Nephrology, 2014
The neonatal Fc receptor (FcRn) is a major regulator of IgG and albumin homeostasis systemically and in the kidneys. We investigated the role of FcRn in the development of immune complex-mediated glomerular disease in mice. C57Bl/6 mice immunized with the noncollagenous domain of the α3 chain of type IV collagen (α3NC1) developed albuminuria associated
Florina, Olaru, Wentian, Luo, Hani, Suleiman, Patricia L, St John, Linna, Ge, Adam R, Mezo, Andrey S, Shaw, Dale R, Abrahamson, Jeffrey H, Miner, Dorin-Bogdan, Borza   +9 more
openaire   +2 more sources

Treatment of pemphigus vulgaris and foliaceus with efgartigimod, a neonatal Fc receptor inhibitor: a phase II multicentre, open‐label feasibility trial *

British Journal of Dermatology, 2021
Pemphigus vulgaris and pemphigus foliaceus are potentially life‐threatening autoimmune disorders triggered by IgG autoantibodies against mucosal and epidermal desmogleins. There is an unmet need for fast‐acting drugs that enable patients to achieve early
M. Goebeler, Z. Bata-Csörgő, C. De Simone, B. Didona, É. Remenyik, N. Reznichenko, J. Stoevesandt, E. Ward, W. Parys, H. Haard, P. Dupuy, P. Verheesen, E. Schmidt, P. Joly   +13 more
semanticscholar   +1 more source

Mapping of the Neonatal Fc Receptor in the Rodent Eye [PDF]

Investigative Opthalmology & Visual Science, 2008
The neonatal Fc receptor (FcRn) has been known to modulate IgG transport and protect against IgG catabolism, resulting in extension of the serum half-life of IgG. The goal of this study was to localize FcRn receptor expression in the rat's eye.The cornea, retina, conjunctiva, ciliary body and iris, retinal pigment epithelium and choroid, and lens were ...
Hyuncheol Kim, Robert N. Fariss, Connie Zhang, Shaun B. Robinson, Michelle Thill, Karl G. Csaky   +5 more
openalex   +4 more sources

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice

Cell Reports, 2015
Immunoglobulin G (IgG) antibodies are major drivers of autoimmune pathology, but they are also used in the form of intravenous IgG (IVIg) therapy to suppress autoantibody activity. To identify the pathways underlying human autoantibody and IVIg activity,
Inessa Schwab, Anja Lux, Falk Nimmerjahn
doaj   +1 more source

Modifying antibody-FcRn interactions to increase the transport of antibodies through the blood-brain barrier

mAbs, 2023
The blood-brain barrier (BBB) largely excludes antibodies from entering the central nervous system, thus limiting the potential of therapeutic antibodies to treat conditions such as neurodegenerative diseases and neuro-psychiatric disorders.
Jason Tien, Dmitri Leonoudakis, Ralitsa Petrova, Vivian Trinh, Tetsuya Taura, Debapriya Sengupta, Lisa Jo, Angela Sho, Yong Yun, Eric Doan, Anita Jamin, Hussein Hallak, David S. Wilson, Jennifer R. Stratton   +13 more
doaj   +1 more source

Engineered clearing agents for the selective depletion of antigen-specific antibodies

Nature Communications, 2017
The depletion of antigen-specific, deleterious antibodies during therapy and diagnosis remains an unsolved challenge. Here the authors develop ‘Seldegs’, antigens linked to human Fc fragments with high affinity for the neonatal Fc receptor FcRn, to ...
Siva Charan Devanaboyina, Priyanka Khare, Dilip K. Challa, Raimund J. Ober, E. Sally Ward   +4 more
doaj   +1 more source

The Chicken Yolk Sac IgY Receptor, a Mammalian Mannose Receptor Family Member, Transcytoses IgY across Polarized Epithelial Cells [PDF]

, 2008
In mammals the transfer of passive immunity from mother to young is mediated by the MHC-related receptor FcRn, which transports maternal IgG across epithelial cell barriers.
Boskovic J., Burmeister W. P., Chaudhury C., Claypool S. M., Cutting J. A., Dawes C., Devin B. Tesar, East L., Ellinger I., Evelyn J. Cheung, Ghetie V., Keith Mostov, Kim J., Koltun M., Kowalczyk K., Larkin J. M., Leach J. L., Lencer W. I., Linden C. D., Martin W. L., Martin W. L., Mayer B., Mayer B., McCarthy K. M., McCarthy K. M., Ober R. J., Ober R. J., Ou S. K., Pamela J. Bjorkman, Praetor A., Rivera-Calzada A., Simister N. E., Simister N. E., Spiekermann G. M., Tesar D. B., Tressler R. L., Ward E. S., West A. P., Western A. H., Wu Z., Yoshida M., Zhu X.   +41 more
core   +2 more sources