Results 71 to 80 of about 19,143 (231)

Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics

International Journal of Cell Biology, 2013
Transport of macromolecules across the blood-brain-barrier (BBB) requires both specific and nonspecific interactions between macromolecules and proteins/receptors expressed on the luminal and/or the abluminal surfaces of the brain capillary endothelial ...
Guangqing Xiao, Liang-Shang Gan
doaj   +1 more source

Human FcRn can mediate the transport across intestinal mucosal barrier and prolong the half-life of rabbit IgG in vivo

Brazilian Archives of Biology and Technology, 2015
FcRn (neonatal Fc receptor) plays an important role in IgG transportation, antigen presentation and signal transmission. In this study, the complement fixation test and flow cytometry test were performed to verify whether the heterologous antibody could ...
Guangchang Pang, Yufang Wang, Junbo Xie, Qingsen Chen, Zhihe Hu   +4 more
doaj   +1 more source

Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of immune-mediated kidney disease [PDF]

, 2020
James Dylewski, Pantipa Tonsawan, Gabriela E. Garcia, Linda Lewis, Judith Blaine   +4 more
openalex   +1 more source

Neonatal Fc receptor induces intravenous immunoglobulin growth suppression in Langerhans cell histiocytosis [PDF]

, 2020
Yuka Nabeshima, Tatsuki R. Kataoka, Chiyuki Ueshima, Narumi Saito, Masahiro Hirata, Yusuke Takei, Koki Moriyoshi, Kazuo Ōno, Hironori Haga   +8 more
openalex   +1 more source

Nipocalimab‐aahu in generalised myasthenia gravis: A new Fc receptor‐targeted option for antibody‐positive patients

Ibrain, EarlyView.
Generalised myasthenia gravis (gMG) can be effectively treated with nipocalimab (Imaavy), a new FcRn inhibitor that selectively lowers harmful IgG levels without causing widespread immunosuppression. According to Phase 2/3 trials, nipocalimab exhibits favourable safety, broad age applicability (≥12 years), and sustained efficacy, setting it apart as a ...
Jawairya Muhammad Hussain, Anoosha Ashfaq, Azka Shahid, Fatima Mudassir   +3 more
wiley   +1 more source

Triage and care for women with symptoms or diagnosis of pregnancy loss between 14 + 0 and 21 + 6 weeks' gestation

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Mid‐trimester pregnancy loss (MTL), defined as a pregnancy loss occurring between 14 + 0 and 21 + 6 weeks of gestation, causes significant physical and emotional distress to women and presents clinical challenges to healthcare professionals. It is acknowledged that in low‐resource settings, this guideline might be applicable to births up to 28 
Caroline E. Fox, Rosinder Kaur, Kugajeevan Vigneswaran, Rachel Small, Jenny Carter, Keelin O'Donoghue, Alexander E. P. Heazell, Anna L. David, Nigel Simpson, Angharad Care, Lisa Starrs, Andrew Shennan, Catalina María Valencia González, Priya Soma‐Pillay, Leah Fitzsimmons, Adam J. Devall, Arri Coomarasamy, Mid‐trimester Pregnancy Loss Guideline Consensus Panel, Owen Arthurs, Ruth Bender‐Atik, Phil Bennett, Kirstien Boelaert, Elizabeth Bonney, Leanna Brace, Naomi Carlisle, Davide Casagrandi, Manju Chandiramani, Carolyn Chiswick, Alexandra Emms, Stella Fielder, James Goadsby, Laura Goodfellow, Jim Gray, Jemma Johns, Emma Kirk, Will Lester, Sophie Mackay, Maria Memtsa, Katie Morris, Sunbal Mukhtar, Naimah Raza, Rita Sarquis, Neil Sebire, Lucy Smith, Lucy Spencer, Amos Tetteh, Natalie Woodhead   +46 more
wiley   +1 more source

Clinical and Biochemical Factors Associated With Infliximab Pharmacokinetics in Adult Patients With Inflammatory Bowel Disease

The Journal of Clinical Pharmacology, EarlyView.
Abstract Many patients with inflammatory bowel disease (IBD) do not adequately respond to infliximab, potentially due to individual differences in pharmacokinetics (PK). This study aimed to identify clinical and biochemical variables associated with infliximab PK.
Ilse A. Pool, Ilse Volkerink, Mirthe Stavast, Jos G. W. Kosterink, Gerard Dijkstra, Paola Mian, Arno R. Bourgonje   +6 more
wiley   +1 more source

Frequency of the polymorphonuclear neutrophil Fc gamma receptor III deficiency in the French population and its involvement in the development of neonatal alloimmune neutropenia [PDF]

, 1992
Patricia Fromont, Ali Bettaı̈eb, H Skouri, Corentin Le Floc’h, E Poulet, N. Duédari, P Bierling   +6 more
openalex   +1 more source

Comparison of Three Different Staging Systems Capable of Predicting the Severity of Congenital Lower Urinary Tract Obstruction (LUTO) and Its Prognosis

Journal of Clinical Ultrasound, EarlyView.
The Ruano's proposed prenatal staging system for LUTO seems to offer a more comprehensive stratification of different severities of fetal LUTO as well as a guidance for potential prenatal therapy based on four stages. ABSTRACT Lower urinary tract obstruction (LUTO) is a rare but severe fetal condition associated with significant morbidity and long‐term
Ugo Maria Pierucci, Irene Paraboschi, Matthieu Peycelon, Chryso P. Katsoufis, Alireza Alam, Gabriele Tonni, Mark D. Kilby, Gloria Pelizzo, Rodrigo Ruano   +8 more
wiley   +1 more source

The relationship between infant feeding types, gut microbiome, intestinal inflammation, and neurodevelopment in a neonatal piglet model

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background The influences of nutrition on the infant's developing gastrointestinal (GI) microbiome, intestinal tract, and brain is unclear. Human milk (HM) is associated with beneficial immune and cognitive development compared with infant formula (IF).
Heidi Sellmann, Janet E. Williams, Klas Udekwu, Ashley McDonough, Katie Heckathorn, Laurel Nuñez, Yimin Chen   +6 more
wiley   +1 more source