Results 81 to 90 of about 109,700 (295)

Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B [PDF]

Cell, 2019
Enterovirus B (EV-B), a major proportion of the genus Enterovirus in the family Picornaviridae, is the causative agent of severe human infectious diseases. Although cellular receptors for coxsackievirus B in EV-B have been identified, receptors mediating virus entry, especially the uncoating process of echovirus and other EV-B remain obscure.
Xin Zhao, Guigen Zhang, Sheng Liu, Xiang-peng Chen, R. Peng, L. Dai, Xiao Qu, Shihua Li, Hao Song, Zhengrong Gao, Pengfei Yuan, Zhiheng Liu, Changyao Li, Zifang Shang, Yan Li, Meifan Zhang, J. Qi, Han Wang, Ning Du, Yan Wu, Y. Bi, Shan Gao, Yi Shi, Jinghua Yan, Yong Zhang, Zhengde Xie, Wensheng Wei, G. Gao   +27 more
semanticscholar   +3 more sources

Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms [PDF]

Journal of Biological Chemistry, 2014
We report the three-dimensional structure of human neonatal Fc receptor (FcRn) bound concurrently to its two known ligands. More particularly, we solved the crystal structure of the complex between human FcRn, wild-type human serum albumin (HSA), and a human Fc engineered for improved pharmacokinetics properties (Fc-YTE). The crystal structure of human
Vaheh, Oganesyan, Melissa M, Damschroder, Kimberly E, Cook, Qing, Li, Changshou, Gao, Herren, Wu, William F, Dall'Acqua   +6 more
openaire   +2 more sources

The Ligands for Human IgG and Their Effector Functions

Antibodies, 2019
Activation of the humoral immune system is initiated when antibodies recognize an antigen and trigger effector functions through the interaction with Fc engaging molecules.
Steven W. de Taeye, Theo Rispens, Gestur Vidarsson   +2 more
doaj   +1 more source

Benefits and Risks of IgG Transplacental Transfer

Diagnostics, 2020
Maternal passage of immunoglobulin G (IgG) is an important passive mechanism for protecting the infant while the neonatal immune system is still immature and ineffective.
Anca Marina Ciobanu, Andreea Elena Dumitru, Nicolae Gica, Radu Botezatu, Gheorghe Peltecu, Anca Maria Panaitescu   +5 more
doaj   +1 more source

Effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes [PDF]

, 2015
Elevated circulating non-esterified fatty acids including oleic acid (OA) are associated with many pregnancy related complications. Prostaglandins (PGs) play crucial roles during parturition.
Aardema, Alves, Arsic, Asselin, Carluccio, Catov, Challis, Chen, Cheng, Cheng, Cheng, Cheng, Cherny, Chu, Crane, D.C. Wathes, D.R.E. Abayasekara, Flynn, Goncalves, Guillou, Herath, Jabbour, Karsch, Kim, Klein, Lamont, Lee, Leung, Lewis, Lunn, M. Elmes, Nielsen, Noble, Poyser, Reddy, Rimoldi, Robinson, S. Kirkup, Sharp, Smith, Smith, Thorburn, Villa, Wang, Wathes, Wendell, Whittle, Witkin, Z. Cheng, Zhang   +49 more
core   +2 more sources

Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering

mAbs, 2022
A conventional antibody targeting a soluble antigen in circulation typically requires a huge dosage and frequent intravenous administration to neutralize the antigen.
Yuji Hori, Ken Ohmine, Hitoshi Katada, Yuki Noguchi, Kazuki Sato, Takeru Nambu, Lam Runyi Adeline, Gan Siok Wan, Kenta Haraya, Kazuhisa Ozeki, Masahiko Nanami, Tatsuhiko Tachibana, Zenjiro Sampei, Taichi Kuramochi, Junichi Nezu, Kunihiro Hattori, Tomoyuki Igawa   +16 more
doaj   +1 more source

Glycoform Modification of Secreted Recombinant Glycoproteins through Kifunensine Addition during Transient Vacuum Agroinfiltration. [PDF]

, 2018
Kifunensine, a potent and selective inhibitor of class I α-mannosidases, prevents α-mannosidases I from trimming mannose residues on glycoproteins, thus resulting in oligomannose-type glycans.
Kailemia, Muchena J, Lebrilla, Carlito B, Li, Qiongyu, McDonald, Karen A, Nandi, Somen, Xiong, Yongao   +5 more
core   +3 more sources

Efficient mucosal vaccination mediated by the neonatal Fc receptor [PDF]

Nature Biotechnology, 2011
Almost all infectious diseases are initiated at mucosal surfaces, yet intramuscular or subcutaneous vaccination usually provides only minimal protection at sites of infection owing to suboptimal activation of the mucosal immune system. The neonatal Fc receptor (FcRn) mediates the transport of IgG across polarized epithelial cells lining mucosal ...
Ye, L, Zeng, R, Bai, Y, Roopenian, D C, Zhu, X   +4 more
openaire   +2 more sources

Isolation and Identification of Porcine Deltacoronavirus and Alteration of Immunoglobulin Transport Receptors in the Intestinal Mucosa of PDCoV-Infected Piglets

Viruses, 2020
Porcine deltacoronavirus (PDCoV) is a porcine enteropathogenic coronavirus that causes watery diarrhea, vomiting, and frequently death in piglets, causing serious economic losses to the pig industry.
Shaoju Qian, Xiangchao Jia, Zitong Gao, Weida Zhang, Qingrong Xu, Zili Li   +5 more
doaj   +1 more source

Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas. [PDF]

, 2019
Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects worldwide, yet the most effective strategies for preventing virus transmission during pregnancy are unknown.
An, Zhiqiang, Fang-Hoover, June, Freed, Daniel C, Fu, Tong-Ming, Li, Fengsheng, Pereira, Lenore, Petitt, Matthew, Tabata, Takako, Wang, Dai   +8 more
core   +1 more source