Results 1 to 10 of about 7,182 (129)

The Neonatal Fc Receptor (FcRn): A Misnomer? [PDF]

Frontiers in Immunology, 2019
Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids.
Michal Pyzik, Kine M. K. Sand, Kine M. K. Sand, Jonathan J. Hubbard, Jonathan J. Hubbard, Jan Terje Andersen, Jan Terje Andersen, Inger Sandlie, Richard S. Blumberg, Richard S. Blumberg   +9 more
doaj   +3 more sources

The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor [PDF]

Nature Communications
Arteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide CRISPR ...
Teressa M. Shaw, Devra Huey, Makky Mousa-Makky, Jared Compaleo, Kylie Nennig, Aadit P. Shah, Fei Jiang, Xueer Qiu, Devon Klipsic, Raymond R. R. Rowland, Igor I. Slukvin, Meagan E. Sullender, Megan T. Baldridge, Haichang Li, Cody J. Warren, Adam L. Bailey   +15 more
doaj   +3 more sources

The neonatal Fc receptor (FcRn): Guardian or Trojan Horse in viral infection? [PDF]

PLoS Pathogens
The neonatal Fc receptor (FcRn), well-known for mediating the transfer of maternal immunoglobulin G (IgG) to neonates, plays a critical role in neonatal antimicrobial defenses.
Lei Na, Yang Zheng, Jian-Bo Yang, Hao-Lin Bao, Yan-Dong Tang   +4 more
doaj   +3 more sources

Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier [PDF]

Nature Communications
The blood-brain barrier (BBB) restricts efficient penetration of systemically delivered therapeutic antibodies into the brain, limiting the development of this class of drugs to treat neurodegenerative diseases.
Julien Lafrance-Vanasse, Shraddha S. Sadekar, Yanli Yang, Daniela Bumbaca Yadav, William J. Meilandt, Monica K. Wetzel-Smith, Hao Cai, Susan R. Crowell, Van Nguyen, Vivian Lee, Ben Chih, Mandy Kwong, Pamela Chan, Sara Santagostino, Donna Lee, Shan Chung, Greg A. Lazar, James A. Ernst, Jasvinder K. Atwal   +18 more
doaj   +3 more sources

Reducing IgG accumulation via neonatal Fc receptor (FcRn) blockade relieves neuropathic pain. [PDF]

Brain Behav Immun
Preclinical and clinical studies have established that autoreactive immunoglobulin G (IgG) can drive neuropathic pain. We recently demonstrated that sciatic nerve chronic constriction injury (CCI) in male and female mice results in the production of ...
Fiore NT, Willcox KF, Dayani D, Zuberi YA, Heijnen CJ, Grace PM.   +5 more
europepmc   +2 more sources

Current state and potential applications of neonatal Fc receptor (FcRn) inhibitors in hematologic conditions. [PDF]

Am J Hematol
The neonatal fragment crystallizable (Fc) receptor (FcRn) transports IgG across mucosal surfaces and the placenta and protects IgG from degradation.
Jacobs JW, Booth GS, Raza S, Clark LM, Fasano RM, Gavriilaki E, Abels EA, Binns TC, Duque MA, McQuilten ZK, Mingot-Castellano ME, Savani BN, Sharma D, Tran MH, Tormey CA, Moise KJ, Bloch EM, Adkins BD.   +17 more
europepmc   +2 more sources

Treatment with anti-neonatal Fc receptor (FcRn) antibody ameliorates experimental epidermolysis bullosa acquisita in mice. [PDF]

Br J Pharmacol, 2020
Pemphigus and pemphigoid diseases are characterized and caused predominantly by IgG autoantibodies targeting structural proteins of the skin. Their current treatment relies on general and prolonged immunosuppression that causes severe adverse events ...
Kasprick A, Hofrichter M, Smith B, Ward P, Bieber K, Shock A, Ludwig RJ, Schmidt E.   +7 more
europepmc   +2 more sources

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics. [PDF]

MAbs, 2018
A large body of data exists demonstrating that neonatal Fc receptor (FcRn) binding of an IgG via its Fc CH2-CH3 interface trends with the pharmacokinetics (PK) of IgG.
Piche-Nicholas NM, Avery LB, King AC, Kavosi M, Wang M, O'Hara DM, Tchistiakova L, Katragadda M.   +7 more
europepmc   +2 more sources

Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin. [PDF]

J Biol Chem, 2017
Albumin is the most abundant plasma protein involved in the transport of many compounds, such as fatty acids, bilirubin, and heme. The endothelial cellular neonatal Fc receptor (FcRn) has been suggested to play a central role in maintaining high albumin ...
Schmidt EGW, Hvam ML, Antunes F, Cameron J, Viuff D, Andersen B, Kristensen NN, Howard KA.   +7 more
europepmc   +2 more sources

Targeting the neonatal Fc receptor (FcRn) to treat autoimmune diseases and maternal-fetal immune cytopenias. [PDF]

Transfusion, 2021
FcRn, a non‐classical Fc gamma (γ) receptor (FcγR) with near ubiquitous expression, plays key roles in disease pathogenesis and progression though immunoglobulin G (IgG) transport, IgG recycling, and IgG‐immune complex clearance.
Wyckoff SL, Hudson KE.
europepmc   +2 more sources