The Neonatal Fc Receptor (FcRn): A Misnomer? [PDF]
Frontiers in Immunology, 2019 Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids.
Michal Pyzik +9 more
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The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor [PDF]
Nature CommunicationsArteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide CRISPR ...
Teressa M. Shaw +15 more
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The neonatal Fc receptor (FcRn): Guardian or Trojan Horse in viral infection? [PDF]
PLoS PathogensThe neonatal Fc receptor (FcRn), well-known for mediating the transfer of maternal immunoglobulin G (IgG) to neonates, plays a critical role in neonatal antimicrobial defenses.
Lei Na +4 more
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Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier [PDF]
Nature CommunicationsThe blood-brain barrier (BBB) restricts efficient penetration of systemically delivered therapeutic antibodies into the brain, limiting the development of this class of drugs to treat neurodegenerative diseases.
Julien Lafrance-Vanasse +18 more
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Characterization of the interactions of rabbit neonatal Fc receptor (FcRn) with rabbit and human IgG isotypes. [PDF]
PLoS ONE, 2017 Despite the increasing importance of rabbit as an animal model in pharmacological studies like investigating placental transfer of therapeutic IgGs, little is known about the molecular interaction of the rabbit neonatal Fc receptor (FcRn) with rabbit and
Bence Szikora +4 more
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The neonatal Fc receptor in cancer FcRn in cancer [PDF]
Cancer Medicine, 2020 Since the neonatal IgG Fc receptor (FcRn) was discovered, it was found to be involved in immunoglobulin recycling and biodistribution, immune complexes routing, antigen presentation, humoral immune response, and cancer immunosurveillance. The latest data
Diana Cadena Castaneda +4 more
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The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy. [PDF]
Adv Drug Deliv Rev, 2015 Immunoglobulin G (IgG)-based drugs are arguably the most successful class of protein therapeutics due in part to their remarkably long blood circulation. This arises from IgG interaction with the neonatal Fc receptor, FcRn. FcRn is the central regulator of IgG and albumin homeostasis throughout life and is increasingly being recognized as an important ...
Sockolosky JT, Szoka FC.
europepmc +8 more sources
The neonatal Fc receptor (FcRn) is required for porcine reproductive and respiratory syndrome virus uncoating. [PDF]
J VirolABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) continues to cause substantial economic losses to the pig industry worldwide. Previous studies from other groups showed that CD163 is required for PRRSV uncoating and genome release. However, CD163 does not interact with nucleocapsid (N) protein. In
Yang K +7 more
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Regulation of immune responses by the neonatal Fc receptor and its therapeutic implications [PDF]
Frontiers in Immunology, 2015 As a single receptor, the neonatal Fc receptor (FcRn) is critically involved in regulating albumin and IgG serum concentrations by protecting these two ligands from degradation.
Timo eRath +4 more
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Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice. [PDF]
MAbs, 2016 The neonatal Fc receptor (FcRn) is a homeostatic receptor responsible for prolonging immunoglobulin G (IgG) half-life by protecting it from lysosomal degradation and recycling it to systemic circulation. Tissue-specific FcRn expression is a critical parameter in physiologically-based pharmacokinetic (PBPK) modeling for translational pharmacokinetics of
Fan YY +5 more
europepmc +5 more sources