Results 51 to 60 of about 8,086 (233)

Human FcRn Tissue Expression Profile and Half-Life in PBMCs

Biomolecules, 2019
System-wide quantitative characterization of human neonatal Fc receptor (FcRn) properties is critical for understanding and predicting human PK (pharmacokinetics) as well as the distribution of mAbs and Fc-fusion proteins using PBPK (physiologically ...
Yao-Yun Fan, Vahid Farrokhi, Teresa Caiazzo, Mengmeng Wang, Denise M. O’Hara, Hendrik Neubert   +5 more
doaj   +1 more source

The influence of antibody engineering on Fc conformation and Fc receptor binding properties: Analysis of FcRn-binding engineered antibodies and an Fc fusion protein

mAbs, 2021
Therapeutic immunoglobulin G (IgG) antibodies have comparatively long half-lives because the neonatal Fc receptor (FcRn) binds to the IgG Fc at acidic pH in the endosome and protects IgG from degradation.
Takuo Suzuki, Noritaka Hashii, Minoru Tada, Akiko Ishii-Watabe   +3 more
doaj   +1 more source

Extending Serum Half-life of Albumin by Engineering Neonatal Fc Receptor (FcRn) Binding [PDF]

Journal of Biological Chemistry, 2014
A major challenge for the therapeutic use of many peptides and proteins is their short circulatory half-life. Albumin has an extended serum half-life of 3 weeks because of its size and FcRn-mediated recycling that prevents intracellular degradation, properties shared with IgG antibodies.
Andersen, Jan Terje, Dalhus, Bjørn, Viuff, Dorthe, Ravn, Birgitte Thue, Gunnarsen, Kristin Støen, Plumridge, Andrew, Bunting, Karen, Antunes, Filipa, Williamson, Rebecca, Athwal, Steven, Allan, Elizabeth, Evans, Leslie, Bjørås, Magnar, Kjærulff, Søren, Sleep, Darrell, Sandlie, Inger, Cameron, Jason   +16 more
openaire   +4 more sources

Structure of FcRY, an avian immunoglobulin receptor related to mammalian mannose receptors, and its complex with IgY [PDF]

, 2011
Fc receptors transport maternal antibodies across epithelial cell barriers to passively immunize newborns. FcRY, the functional counterpart of mammalian FcRn (a major histocompatibility complex homolog), transfers IgY across the avian yolk sac, and ...
BENNETT, Bottcher, Burmeister, Dube, East, Kowalczyk, Leach, Linden, Llorca, Martin, Mayer, Mertens, P. J. Bjorkman, Rivera-Calzada, Roopenian, Simister, Simister, Taylor, Tressler, Vaughn, Western, Woof, Y. He   +22 more
core   +3 more sources

PEGylation enhances the therapeutic potential of peptide antagonists of the neonatal Fc receptor, FcRn

Bioorganic & Medicinal Chemistry Letters, 2011
Peptides targeting the human neonatal Fc receptor (FcRn) were conjugated to poly(ethylene glycol) (PEG) polymers to study their effect on inhibition of the IgG:FcRn protein-protein interaction both in vitro and in mice. Both linear (5-40kDa) and branched (20, 40kDa) PEG aldehydes were conjugated to an amine-containing linker of a homodimeric anti-FcRn ...
Adam R. Mezo, Susan C. Low, Todd Hoehn, Holly Palmieri   +3 more
openalex   +3 more sources

Neonatal Fc receptor (FcRn) and maternal‐to‐newborn IgE absorption [PDF]

Clinical & Experimental Allergy, 2012
From 1949-1966, a series of experimental studies by Professor F. W. Rogers Brambell (1901-1970; memoirs (1)) revealed the transmission of immunoglobulin from the mother to the fetus and newborn (2-4). In 1966, he published a review article in The Lancet describing that the selective transmission of γ-globulin from the mother to the offspring could ...
openaire   +2 more sources

The Chicken Yolk Sac IgY Receptor, a Mammalian Mannose Receptor Family Member, Transcytoses IgY across Polarized Epithelial Cells [PDF]

, 2008
In mammals the transfer of passive immunity from mother to young is mediated by the MHC-related receptor FcRn, which transports maternal IgG across epithelial cell barriers.
Boskovic J., Burmeister W. P., Chaudhury C., Claypool S. M., Cutting J. A., Dawes C., Devin B. Tesar, East L., Ellinger I., Evelyn J. Cheung, Ghetie V., Keith Mostov, Kim J., Koltun M., Kowalczyk K., Larkin J. M., Leach J. L., Lencer W. I., Linden C. D., Martin W. L., Martin W. L., Mayer B., Mayer B., McCarthy K. M., McCarthy K. M., Ober R. J., Ober R. J., Ou S. K., Pamela J. Bjorkman, Praetor A., Rivera-Calzada A., Simister N. E., Simister N. E., Spiekermann G. M., Tesar D. B., Tressler R. L., Ward E. S., West A. P., Western A. H., Wu Z., Yoshida M., Zhu X.   +41 more
core   +2 more sources

Human IgE does not bind to human FcRn

Scientific Reports, 2022
The neonatal Fc receptor (FcRn) is known to mediate placental transfer of IgG from mother to unborn. IgE is widely known for triggering immune responses to environmental antigens.
Maximilian Brinkhaus, Elvera J. van der Kooi, Arthur E. H. Bentlage, Pleuni Ooijevaar-de Heer, Ninotska I. L. Derksen, Theo Rispens, Gestur Vidarsson   +6 more
doaj   +1 more source

A preliminary study of expression of human neonatal Fc-receptor (FcRn) in Escherichia coli

Asian Pacific Journal of Tropical Disease, 2014
Abstract Introduction Human neonatal Fc-receptor is a potential novel antibody binding protein for development of immunoassay. Previous studies had shown that this human protein has high affinity to Ig G either in vivo or in vitro. However, none of the studies had attempted exploring the utility of human FcRn in antibody immobilisation strategy.
Woei Kean Ng, T.S. Limz, Ngit Shin Lai
openalex   +2 more sources

New roles for Fc receptors in neurodegeneration-the impact on immunotherapy for Alzheimer's disease [PDF]

, 2014
There are an estimated 18 million Alzheimer's disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Fuller, James P., Stavenhagen, Jeffrey B., Teeling, Jessica L.   +2 more
core   +3 more sources