Results 91 to 100 of about 615,914 (313)
C030 | GENOTYPE-PHENOTYPE CORRELATES AND OUTCOMES OF EXTRAMEDULLARY ACUTE MYELOID LEUKEMIA
HaematologicaBackground: Genomic abnormalities associated with extramedullary (EM) acute myeloid leukemia (eAML) and their impact on clinical outcomes are not well understood since previous studies were limited to small case series with controversial results.
G.G. Loscocco +12 more
doaj
BMC Bioinformatics, 2019 Background Predicting meaningful miRNA-disease associations (MDAs) is costly. Therefore, an increasing number of researchers are beginning to focus on methods to predict potential MDAs.
Ying-Lian Gao +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
A Computational Approach for Identifying Plant-Based Foods for Addressing Vitamin Deficiency Diseases [PDF]
, 2015 Vitamins are nutrients that are essential to human health, and deficiencies have been shown to cause severe diseases. In this study, a computational approach was used to identify vitamin deficiency diseases and plant-based foods with vitamin content ...
Sarkar, Indra Neil, Yu, Christina
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Experimentally Produced Neoplasms in the Frog.
Experimental Biology and Medicine, 1930 It has been known that the frog egg on the stage of the second polar spindle-metaphase passes into a resting period, awaiting fertilization. Under natural conditions this lasts for only a few hours, but can be delayed up to 3 days without impairing perceptibly the vigor of the egg. After a further delay of 2 days, however, the eggs are dead.
openaire +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Mutations and thrombosis in essential thrombocythemia
Blood Cancer Journal, 2021 Paola Guglielmelli +12 more
doaj +1 more source