Results 41 to 50 of about 8,661 (199)

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Mullerian adenosarcoma-like tumor arising from an extragonadal germ cell tumor: Case Report and Literature Review

Human Pathology Reports
Extragonadal germ cell tumors (GCTs) are rare neoplasms, accounting for 1–5 % of all germ cell tumors. Mixed germ cell tumors are neoplasms with more than one GCT component.
Pauline Biesemans, Marcella Baldewijns, Steven Joniau, Tim Van Assche, Marc Claessens, Robert Hente, Wies Vanderbruggen, Wim Volders, Anne-Sophie Van Rompuy   +8 more
doaj   +1 more source

An Unusual Case of Primary Retroperitoneal Germ Cell Tumour in a Young Man

European Journal of Case Reports in Internal Medicine, 2018
Some 2–5% of germ cell tumours are of extragonadal origin, with a retroperitoneal location being very rare. The majority of retroperitoneal germ cell tumours have metastasized from a testicular tumour.
Maria João Raposo Linhares Serpa, Susana Franco, Diana Repolho, Francisco Branco, João Gramaça, José Ferreira Júnior   +5 more
doaj   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Unusual presentation of fetal ventriculomegaly: a case report [PDF]

Journal of Medicine and Life Science
Fetal ventriculomegaly (VM) is a relatively common finding during prenatal examinations and occurs in approximately 0.2% of live births. Although there are various causes, obstructive VM due to cerebellar hemorrhage is exceedingly rare.
Sang Yoon Lee
doaj   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Diagnosis and management of a rare bilateral ovarian mixed germ cell tumor: a case report

Frontiers in Oncology
BackgroundMixed ovarian malignant germ cell tumors (MOGCTs) are rare neoplasms composed of two or more malignant germ cell components, representing less than 1% of all ovarian germ cell tumors.
Xuanling Li, Min You, Xiaoyun Zhang, Jingjing Wei, Guangyao Lin, Qianjue Tang, Lianwei Xu   +6 more
doaj   +1 more source

Modern competency‐based teaching of human sexual development

Anatomical Sciences Education, EarlyView.
Abstract Embryology is an integral part of anatomy and a key subject in basic medical education. The development of the sexual tract, which is closely associated with the formation of the urinary tract and the organs of continence, is particularly complex and relevant for many medical disciplines.
Elisabeth Eppler, Alessandro Bilella, Christian M. Hammer   +2 more
wiley   +1 more source

Burned-Out Testicular Tumour: An Unusual Presentation

Gazeta Médica
Although being relatively uncommon, testicular primary germ cell tumours represent most of testicular tumours in young and middle-aged men. Metastatic disease accounts for up to ten percent of initial presentation. A 31-year-old man presented with a two-
Nuno Santos Sousa, Duarte Santos-Sousa, Rafaela Miranda, Andreia Coutada, Mariana Afonso, Simão Costa Martins   +5 more
doaj   +1 more source