Results 81 to 90 of about 9,124 (231)

Inhibition of HMGA2 Leads to Reduced Cell Proliferation and Increased Apoptosis in Human Embryonal Carcinoma Cell Lines

Andrology, EarlyView.
ABSTRACT Background The most prevalent solid tumors in young men are testicular germ cell tumors (TGCTs), and embryonal carcinoma is the most common subtype among non‐seminomatous germ cell tumors (NSGCTs). Despite the excellent cure rates of cisplatin‐based chemotherapy, resistance develops in 15%–30% of patients with metastatic cancer, which results ...
Marco De Martino, Matteo Lampitto, Alfredo Fusco, Marco Barchi, Francesco Esposito, Paolo Chieffi   +5 more
wiley   +1 more source

Isoelectric focusing of alpha-L-fucosidase from human embryonal carcinoma.

, 1986
Isoelectric focusing profiles of alpha-L-fucosidase recovered from human embryonal carcinoma (EC) and seminoma were compared with those of mouse germ cell tumor-derived stem cells and some human somatic cell neoplasms in an attempt to determine whether ...
Damjanov, I, Alhadeff, J A, Laury-Kleintop, L D   +2 more
core   +1 more source

Nucleolin and nucleophosmin expression in seminomas and non-seminomatous testicular tumors [PDF]

, 2019
Introduction. Testicular tumors are heterogeneous group of neoplasms divided mainly into two types: seminomas and non-seminomas. Nucleolin (NCL) and nucleophosmin (NPM) are abundant nucleolar proteins involved in many physiologic and pathologic processes
Lewandowska, Magdalena; Department of Pathology, Pomeranian Medical University, Szczecin, Poland, Urasinska, Elzbieta; Department of Pathology, Pomeranian Medical University, Szczecin, Poland, Teresinski, Leszek; Laboratory of Pathology, Multispecialty Hospital, ul. Dekerta 1, 66-400 Gorzów Wielkopolski, Poland, Dobak, Ewa; Department of Pathology, Pomeranian Medical University, Szczecin, Poland, Masiuk, Marek; Department of Pathology, Pomeranian Medical University, Szczecin, Poland; Laboratory of Pathology, Multispecialty Hospital, ul. Dekerta 1, 66-400 Gorzów Wielkopolski, Poland   +4 more
core   +1 more source

A Unified Machine Learning Model for Relapse Prediction in Clinical Stage I Testicular Cancer

Andrology, EarlyView.
ABSTRACT Background Approximately one‐fourth of patients with clinical stage I testicular cancer relapse. For decades, risk stratification has been based on different tumor characteristics for seminomas and non‐seminomas. Previous studies primarily used Cox proportional‐hazards models and included only a limited number of variables.
Thomas Wagner, Ramtin Zargari Marandi, Jakob Lauritsen, Daniel Dawson Murray, Mikkel Bandak, Birgitte Grønkær Toft, Dan Berney, Gedske Daugaard   +7 more
wiley   +1 more source

Neoplasms of the Testis

, 2013
Testicular cancer accounts for about 1 % of all cancers in men. Malignant testicular tumors are divided into two main groups: germ cell tumors and non-germ cell tumors.
Gregory T. MacLennan, Francesca Cacciato, Pietro Pavlica, Massimo Valentino, Michele Bertolotto, Giuseppe Tona, CACCIATO, FRANCESCA, Libero Barozzi, Lorenzo E. Derchi, BERTOLOTTO, MICHELE, Ercan Kocakoc   +10 more
core   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Walsh & Hoyt: Germ Cell Tumors

, 2005
Tumors of germ cell derivation represent five interrelated neoplasms that demonstrate a hierarchic order of increasing malignant behavior: germinoma, teratoma (including immature and malignant forms), embryonal carcinoma, endodermal sinus tumor, and ...
Karl C. Golnik, MD
core  

Impact of Chemotherapy on Sperm Functional Characteristics in Patients With Testicular Germ Cell Tumours

Andrology, EarlyView.
ABSTRACT Background Testicular germ cell tumours (TGCT) are the most common malignancies among young men and represent a major threat to reproductive health. Both the disease itself and oncological treatments, particularly chemotherapy, can compromise spermatogenesis and semen quality.
Ondrej Sanovec, Ondrej Simonik, Zuzana Kratka, Lukas Ded, Jana Vondrakova, Maryam Qasemi, Barbora Bryndova, Michala Krejci, Daniela Spevakova, Vishma Pratap Sur, Radomir Kren, Tomas Hradec, Pavel Skrobanek, Ludmila Boublikova, Libor Zamecnik, Tomas Buchler, Jiri Neuzil, Pavla Postlerova, Katerina Komrskova   +18 more
wiley   +1 more source

Involvement of dysadherin and E-cadherin in the development of testicular tumours [PDF]

, 2005
Testicular neoplasms are comprised of a variety of histologically different forms, and their pathogenesis has not been elucidated. Dysadherin is a recently described cell membrane glycoprotein, which has an anticell-cell adhesion function and ...
Nakanishi, Y., Agnantis, N. J., Ravazoula, P., Hirohashi, S., Charalabopoulos, K. A., Peschos, D., Batistatou, A., Scopa, C. D.   +7 more
core  

In Situ Expression of miR‐371a‐3p and miR‐373‐3p in Testicular Germ Cell Tumours and Detection in Serum

Andrology, EarlyView.
ABSTRACT Background Testicular germ cell tumours (TGCTs) are the most common type of tumour diagnosed in young men, and reliable non‐invasive biomarkers are crucial for clinical management. MicroRNAs (miRNAs) from the miR‐371–373 cluster have recently been identified as novel and more sensitive serum biomarkers than the conventional protein‐based ...
Nina Mørup, Merve Tatli, Thomas Wagner, Helle Margit Albrechtsen, Gülizar Saritas, Gedske Daugaard, Sofia B. Winge, Kristian Almstrup   +7 more
wiley   +1 more source