Results 1 to 10 of about 1,294,519 (330)
Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells [PDF]
Nature Communications, 2017 Renal angiomyolipomas (AML) contain a mix of clonal tumour cells. Here, through reverse tumour engineering experiments, mouse genetics and analyses of human AML tumours, the authors provide evidence that these mesenchymal tumours originate from renal ...
Ana Filipa Gonçalves +8 more
doaj +8 more sources
Normal and Neoplastic Stem Cells. [PDF]
Cold Spring Harb Symp Quant Biol, 2016 A stem cell is broadly defined as a cell that retains the capacity to self-renew, a feature that confers the ability to continuously make identical daughter cells or additional cells that will differentiate into downstream progeny.
McCracken MN +5 more
europepmc +5 more sources
Redistribution, homing and organ-invasion of neoplastic stem cells in myeloid neoplasms. [PDF]
Semin Cancer Biol, 2020 The development of a myeloid neoplasm is a step-wise process that originates from leukemic stem cells (LSC) and includes pre-leukemic stages, overt leukemia and a drug-resistant terminal phase.
Valent P +8 more
europepmc +5 more sources
Frontiers in Cell and Developmental Biology, 2022 Mesenchymal stem cells (MSCs), as adult multipotent cells, possess considerable regenerative and anti-neoplastic effects, from inducing apoptosis in the cancer cells to reducing multidrug resistance that bring them up as an appropriate alternative for ...
Kasra Moeinabadi-Bidgoli +6 more
doaj +2 more sources
Heterogeneity of neoplastic stem cells: theoretical, functional, and clinical implications. [PDF]
Cancer Research, 2013 Abstract Accumulating evidence suggests that human cancers develop through a step-wise, but nonlinear process of cellular diversification and evolution. Recent mutational analyses indicate that this process is more complex and diverse than anticipated before whole-genome sequencing methods were readily available.
Peter Valent +6 more
semanticscholar +3 more sources
Normal and neoplastic stem cells.
Experimental Hematology, 2015 Stem cells are cells that at the single cell level both self-renew and give rise to differentiated progeny. Self renewal is the property that distinguishes stem cells and progenitors, and in the blood-forming system explains why haematopoietic stem cells (HSCs), not progenitors, are the only cells capable of providing rapid and sustained regeneration ...
I. Weissman
semanticscholar +3 more sources
Neoplastic stem cells: A novel therapeutic target in clinical oncology [PDF]
Cancer, 2006 AbstractCancer is among the leading causes of morbidity and mortality in the Western world. Despite recent advances, most therapeutic approaches fail to eradicate the entire neoplastic clone. The remaining cells often develop metastasis and/or recurrences and therefore may represent attractive targets of therapy.
A. Schulenburg +10 more
semanticscholar +3 more sources
Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential [PDF]
The EMBO Journal, 2016 Aneuploidy leads to severe developmental defects in mammals and is also a hallmark of cancer. However, whether aneuploidy is a driving cause or a consequence of tumor formation remains controversial. Paradoxically, existing studies based on aneuploid yeast and mouse fibroblasts have shown that aneuploidy is usually detrimental to cellular fitness. Here,
Meili Zhang +7 more
semanticscholar +3 more sources
Insights on neoplastic stem cells from gel‐based proteomics of childhood germ cell tumors [PDF]
Pediatric Blood & Cancer, 2012 AbstractBackgroundChildhood germ cell tumors (cGCTs), believed to arise from transformed primordial germ cells by an unknown mechanism, provide a unique model system for investigating cell signaling, pluripotency, and the microenvironment of neoplastic stem cells (NSCs) in vivo.
W. Haskins +5 more
semanticscholar +3 more sources
Divergent modulation of normal and neoplastic stem cells by thrombospondin-1 and CD47 signaling. [PDF]
Int J Biochem Cell Biol, 2016 Kaur S, Roberts DD.
europepmc +2 more sources