Results 1 to 10 of about 432,951 (336)

Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells [PDF]

Nature Communications, 2017
Renal angiomyolipomas (AML) contain a mix of clonal tumour cells. Here, through reverse tumour engineering experiments, mouse genetics and analyses of human AML tumours, the authors provide evidence that these mesenchymal tumours originate from renal ...
Ana Filipa Gonçalves, Mojca Adlesic, Simone Brandt, Tomas Hejhal, Sabine Harlander, Lukas Sommer, Olga Shakhova, Peter J. Wild, Ian J. Frew   +8 more
doaj   +7 more sources

Redistribution, homing and organ-invasion of neoplastic stem cells in myeloid neoplasms. [PDF]

Semin Cancer Biol, 2020
The development of a myeloid neoplasm is a step-wise process that originates from leukemic stem cells (LSC) and includes pre-leukemic stages, overt leukemia and a drug-resistant terminal phase. Organ-invasion may occur in any stage, but is usually associated with advanced disease and a poor prognosis.
Valent P, Sadovnik I, Eisenwort G, Herrmann H, Bauer K, Mueller N, Sperr WR, Wicklein D, Schumacher U.   +8 more
europepmc   +6 more sources

Neoplastic Bone Marrow Niche: Hematopoietic and Mesenchymal Stem Cells [PDF]

Cell Journal, 2011
The neoplastic niche comprises complex interactions between multiple cell typesand molecules requiring cell-cell signaling as well as local secretion. These nichesare important for both the maintenance of cancer stem cells and the inductionof neoplastic ...
Saeid Abroun, Najmaldin Saki, Farahnaz Asgharei, Majid Farshdousti Hagh   +3 more
doaj   +4 more sources

Divergent modulation of normal and neoplastic stem cells by thrombospondin-1 and CD47 signaling. [PDF]

Int J Biochem Cell Biol, 2016
Kaur S, Roberts DD.
europepmc   +3 more sources

Evaluation of in vitro effects of various targeted drugs on plasma cells and putative neoplastic stem cells in patients with multiple myeloma. [PDF]

Oncotarget, 2016
Blatt K, Herrmann H, Stefanzl G, Sperr WR, Valent P.   +4 more
europepmc   +3 more sources

Cell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma. [PDF]

, 2010
The intrinsic oncolytic specificity of vesicular stomatitis virus (VSV) is currently being exploited to develop alternative therapeutic strategies for hepatocellular carcinoma (HCC). Identifying key regulators in diverse transduction pathways that define
A Bianchini, A Villanueva, Alexandra Junger, Antonia Rizzani, DA Altomare, EF Dunn, Enrico N. De Toni, Günter Schneider, HG Wendel, I Fabregat, I Nicoletti, IBCJ Rosenwald, JE Dancey, Jennifer Altomonte, JH Connor, JS Orlando, K Shinozaki, K Shinozaki, L Mishra, LM Schang, M Ahmed, M Hidalgo, M Ikeda, M Sun, Maciej Lesniak, N Kato, N Kato, N Kemeny, N Sonenberg, NA Hamid, Nobuyuki Kato, O Ebert, O Ebert, O Larsson, Oliver Ebert, P Chakraborty, P Newell, PC Chiang, PL Hallenbeck, RB Kjellerup, RL Silva, RM Memmott, Roland M. Schmid, S Balachandran, S Joshi, S Marozin, S Oliere, S Sei, S Sell, Sabrina Marozin, SM Steinberg, SR Kimball, T Cascone, T Nakamura, T Ueda, TL Nguyen, TP Cripe, WE Thasler, Wolfgang E. Thasler, XQ Lun, Y Ma   +60 more
core   +23 more sources

Mesenchymal Stem Cells, Bioactive Factors, and Scaffolds in Bone Repair: From Research Perspectives to Clinical Practice

Cells, 2021
Mesenchymal stem cell-based therapies are promising tools for bone tissue regeneration. However, tracking cells and maintaining them in the site of injury is difficult. A potential solution is to seed the cells onto a biocompatible scaffold.
Sandra Stamnitz, Aleksandra Klimczak
doaj   +1 more source

Osteogenic Potential of Sheep Mesenchymal Stem Cells Preconditioned with BMP-2 and FGF-2 and Seeded on an nHAP-Coated PCL/HAP/β-TCP Scaffold

Cells, 2022
Mesenchymal stem cells (MSCs) attract interest in regenerative medicine for their potential application in bone regeneration. However, direct transplantation of cells into damaged tissue is not efficient enough to regenerate large bone defects.
Sandra Stamnitz, Agnieszka Krawczenko, Urszula Szałaj, Żaneta Górecka, Agnieszka Antończyk, Zdzisław Kiełbowicz, Wojciech Święszkowski, Witold Łojkowski, Aleksandra Klimczak   +8 more
doaj   +1 more source

Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival [PDF]

, 2015
Leukemic cells from Chronic Lymphocytic Leukemia (CLL) patients interact with stromal cells of the surrounding microenvironment. Mesenchymal Stromal Cells (MSCs) represent the main population in CLL marrow stroma, which may play a key role for disease ...
Ave, Elisa, Castelli, Monica, Chiodin, Giorgia, Facco, Monica, Frezzato, Federica, Gattazzo, Cristina, Giorgi, CARLO ALBERTO, Lessi, Federica, Martini, Veronica, Piazza, Francesco, Semenzato, GIANPIETRO CARLO, Severin, Filippo, Trentin, Livio, Trimarco, Valentina, Visentin, Andrea, Zambello, Renato   +15 more
core   +10 more sources

Leukemic stem cell frequency: a strong biomarker for clinical outcome in acute myeloid leukemia. [PDF]

PLoS ONE, 2014
INTRODUCTION: Treatment failure in acute myeloid leukemia is probably caused by the presence of leukemia initiating cells, also referred to as leukemic stem cells, at diagnosis and their persistence after therapy. Specific identification of leukemia stem
Monique Terwijn, Wendelien Zeijlemaker, Angèle Kelder, Arjo P Rutten, Alexander N Snel, Willemijn J Scholten, Thomas Pabst, Gregor Verhoef, Bob Löwenberg, Sonja Zweegman, Gert J Ossenkoppele, Gerrit J Schuurhuis   +11 more
doaj   +1 more source