Results 1 to 10 of about 417,028 (237)

Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells [PDF]

Nature Communications, 2017
Renal angiomyolipomas (AML) contain a mix of clonal tumour cells. Here, through reverse tumour engineering experiments, mouse genetics and analyses of human AML tumours, the authors provide evidence that these mesenchymal tumours originate from renal ...
Ana Filipa Gonçalves, Mojca Adlesic, Simone Brandt, Tomas Hejhal, Sabine Harlander, Lukas Sommer, Olga Shakhova, Peter J. Wild, Ian J. Frew   +8 more
doaj   +8 more sources

MicroRNAs involved in neoplastic transformation of liver cancer stem cells [PDF]

Journal of Experimental & Clinical Cancer Research, 2010
Background The existence of cancer stem cells in hepatocellular carcinoma (HCC) has been verified by characterizing side population (SP) cells based on efflux of Hoechst 33342 dye from stem cells. Recent advances in microRNA (miRNA) biology have revealed
Wang Xinchuan, You Nan, Tao Kaishan, Qian Niansong, Li Ren, Dou Kefeng   +5 more
doaj   +6 more sources

Mesenchymal Stem Cells, Bioactive Factors, and Scaffolds in Bone Repair: From Research Perspectives to Clinical Practice

Cells, 2021
Mesenchymal stem cell-based therapies are promising tools for bone tissue regeneration. However, tracking cells and maintaining them in the site of injury is difficult. A potential solution is to seed the cells onto a biocompatible scaffold.
Sandra Stamnitz, Aleksandra Klimczak
doaj   +1 more source

Cell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma. [PDF]

, 2010
The intrinsic oncolytic specificity of vesicular stomatitis virus (VSV) is currently being exploited to develop alternative therapeutic strategies for hepatocellular carcinoma (HCC). Identifying key regulators in diverse transduction pathways that define
Altomonte, Jennifer, De Toni, Enrico N., Ebert, Oliver, Junger, Alexandra, Kato, Nobuyuki, Marozin, Sabrina, Rizzani, Antonia, Schmid, Roland M., Schneider, Günter, Thasler, Wolfgang E.   +9 more
core   +18 more sources

Osteogenic Potential of Sheep Mesenchymal Stem Cells Preconditioned with BMP-2 and FGF-2 and Seeded on an nHAP-Coated PCL/HAP/β-TCP Scaffold

Cells, 2022
Mesenchymal stem cells (MSCs) attract interest in regenerative medicine for their potential application in bone regeneration. However, direct transplantation of cells into damaged tissue is not efficient enough to regenerate large bone defects.
Sandra Stamnitz, Agnieszka Krawczenko, Urszula Szałaj, Żaneta Górecka, Agnieszka Antończyk, Zdzisław Kiełbowicz, Wojciech Święszkowski, Witold Łojkowski, Aleksandra Klimczak   +8 more
doaj   +1 more source

Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival [PDF]

, 2015
Leukemic cells from Chronic Lymphocytic Leukemia (CLL) patients interact with stromal cells of the surrounding microenvironment. Mesenchymal Stromal Cells (MSCs) represent the main population in CLL marrow stroma, which may play a key role for disease ...
Ave, Elisa, Castelli, Monica, Chiodin, Giorgia, Facco, Monica, Frezzato, Federica, Gattazzo, Cristina, Giorgi, CARLO ALBERTO, Lessi, Federica, Martini, Veronica, Piazza, Francesco, Semenzato, GIANPIETRO CARLO, Severin, Filippo, Trentin, Livio, Trimarco, Valentina, Visentin, Andrea, Zambello, Renato   +15 more
core   +10 more sources

Leukemic stem cell frequency: a strong biomarker for clinical outcome in acute myeloid leukemia. [PDF]

PLoS ONE, 2014
INTRODUCTION: Treatment failure in acute myeloid leukemia is probably caused by the presence of leukemia initiating cells, also referred to as leukemic stem cells, at diagnosis and their persistence after therapy. Specific identification of leukemia stem
Monique Terwijn, Wendelien Zeijlemaker, Angèle Kelder, Arjo P Rutten, Alexander N Snel, Willemijn J Scholten, Thomas Pabst, Gregor Verhoef, Bob Löwenberg, Sonja Zweegman, Gert J Ossenkoppele, Gerrit J Schuurhuis   +11 more
doaj   +1 more source

Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

eLife, 2021
Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness.
Brian Spurlock, Danitra Parker, Malay Kumar Basu, Anita Hjelmeland, Sajina GC, Shanrun Liu, Gene P Siegal, Alan Gunter, Aida Moran, Kasturi Mitra   +9 more
doaj   +1 more source

Co-Transplantation of Bone Marrow-MSCs and Myogenic Stem/Progenitor Cells from Adult Donors Improves Muscle Function of Patients with Duchenne Muscular Dystrophy

Cells, 2020
Duchenne muscular dystrophy (DMD) is a genetic disorder associated with a progressive deficiency of dystrophin that leads to skeletal muscle degeneration.
Aleksandra Klimczak, Agnieszka Zimna, Agnieszka Malcher, Urszula Kozlowska, Katarzyna Futoma, Jaroslaw Czarnota, Pawel Kemnitz, Anna Bryl, Maciej Kurpisz   +8 more
doaj   +1 more source

Immunohistochemical expression of OCT4 and CD44 in major and minor salivary gland neoplasms

Brazilian Oral Research, 2021
The aim of this study was to identify tumor parenchyma cells exhibiting immunohistochemical profile of stem cells by evaluating the immunoreactivity of OCT4 and CD44 in a number of cases of salivary gland neoplasms. The sample consisted of 20 pleomorphic
Jamile Marinho Bezerra de Oliveira Moura, Amanda Katarinny Goes Gonzaga, Salomão Israel Monteiro Lourenço Queiroz, Manoela Domingues Martins, Leão Pereira Pinto, Lélia Batista de Souza   +5 more
doaj   +1 more source