Results 11 to 20 of about 417,028 (237)
STEM CELL IN GASTROINTESTINAL STRUCTURE AND NEOPLASTIC DEVELOPMENT [PDF]
Gut, 2004 Stem cells are primitive cells located in a specialised mesenchymal “niche” that lack expression of any definitive markers of lineage commitment and are therefore difficult to define and identify. Stem cells maintain their capacity for limitless self replication throughout the lifetime of their host, and can also divide to produce daughter cells ...
Mairi Brittan
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Adult human mesenchymal stem cell as a target for neoplastic transformation [PDF]
Oncogene, 2004 The neoplastic process may involve a cancer stem cell. This concept has emerged largely from the careful analysis of tumour biopsy systems from haematological, breast and brain tumours. However, the experimental systems necessary to provide the cellular and molecular evidence to support this important concept have been lacking.
Nedime Serakıncı +6 more
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Normal and Neoplastic Stem Cells. [PDF]
Cold Spring Harb Symp Quant Biol, 2016 A stem cell is broadly defined as a cell that retains the capacity to self-renew, a feature that confers the ability to continuously make identical daughter cells or additional cells that will differentiate into downstream progeny. This highly regulated genetic program to retain "stemness" is under active investigation.
McCracken MN +5 more
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Neoplastic Bone Marrow Niche: Hematopoietic and Mesenchymal Stem Cells [PDF]
Cell Journal, 2011 The neoplastic niche comprises complex interactions between multiple cell typesand molecules requiring cell-cell signaling as well as local secretion. These nichesare important for both the maintenance of cancer stem cells and the inductionof neoplastic ...
Saeid Abroun +3 more
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Normal and neoplastic urothelial stem cells: getting to the root of the problem [PDF]
Nature Reviews Urology, 2012 Most epithelial tissues contain self-renewing stem cells that mature into downstream progenies with increasingly limited differentiation potential. It is not surprising that cancers arising from such hierarchically organized epithelial tissues retain features of cellular differentiation. Accumulating evidence suggests that the urothelium of the urinary
Philip Levy Ho +2 more
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Redistribution, homing and organ-invasion of neoplastic stem cells in myeloid neoplasms. [PDF]
Semin Cancer Biol, 2020 The development of a myeloid neoplasm is a step-wise process that originates from leukemic stem cells (LSC) and includes pre-leukemic stages, overt leukemia and a drug-resistant terminal phase. Organ-invasion may occur in any stage, but is usually associated with advanced disease and a poor prognosis.
Valent P +8 more
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Identification of normal and neoplastic stem cells by the multicolor lineage tracing methods [PDF]
Pathology International, 2016 Adult stem cells and embryonic (ES) and induced pluripotent stem (iPS) cells are two major focus areas of stem cell research. Studies on adult stem cells are important not only as sources for regenerative medicine but for analyzing the mechanisms of tissue homeostasis, tissue repair after injury, cancinogenesis, and aging. On the other hand, ES and iPS
Hiroo Ueno
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Thrombopoietin in normal and neoplastic stem cell development [PDF]
Best Practice & Research Clinical Haematology, 2009 It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia
Kenneth Kaushansky, Helen M. Ranney
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Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon [PDF]
Cell Reports, 2019 Human intestinal stem cell and crypt dynamics remain poorly characterized because transgenic lineage-tracing methods are impractical in humans. Here, we have circumvented this problem by quantitatively using somatic mtDNA mutations to trace clonal lineages.
Ann‐Marie Baker +12 more
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GRP78 promotes stemness in normal and neoplastic cells [PDF]
Scientific Reports, 2019 ABSTRACTReliable approaches to identify stem cell mechanisms that mediate aggressive cancer could have great therapeutic value, based on the growing evidence of embryonic signatures in metastatic cancers. However, how to best identify and target stem-like mechanisms aberrantly acquired by cancer cells has been challenging.
Conner, Clay +13 more
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