Results 11 to 20 of about 432,951 (336)

Cell surface GRP78 promotes stemness in normal and neoplastic cells [PDF]

Scientific Reports, 2020
Abstract Reliable approaches to identify stem cell mechanisms that mediate aggressive cancer could have great therapeutic value, based on the growing evidence of embryonic signatures in metastatic cancers. However, how to best identify and target stem-like mechanisms aberrantly acquired by cancer cells has been ...
Clay Conner, Tyson W. Lager, Ian H. Guldner, Min-Zu Wu, Yuriko Hishida, Tomoaki Hishida, Sergio Ruiz, Amanda E. Yamasaki, Robert Christopher Gilson, Juan Carlos Izpisúa Belmonte, Peter C. Gray, Jonathan A. Kelber, Siyuan Zhang, Athanasia D. Panopoulos   +13 more
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MicroRNAs involved in neoplastic transformation of liver cancer stem cells [PDF]

Journal of Experimental & Clinical Cancer Research, 2010
Background The existence of cancer stem cells in hepatocellular carcinoma (HCC) has been verified by characterizing side population (SP) cells based on efflux of Hoechst 33342 dye from stem cells. Recent advances in microRNA (miRNA) biology have revealed
Wang Xinchuan, You Nan, Tao Kaishan, Qian Niansong, Li Ren, Dou Kefeng   +5 more
doaj   +3 more sources

Normal and Neoplastic Stem Cells. [PDF]

Cold Spring Harb Symp Quant Biol, 2016
A stem cell is broadly defined as a cell that retains the capacity to self-renew, a feature that confers the ability to continuously make identical daughter cells or additional cells that will differentiate into downstream progeny. This highly regulated genetic program to retain "stemness" is under active investigation.
McCracken MN, George BM, Kao KS, Marjon KD, Raveh T, Weissman IL.   +5 more
europepmc   +4 more sources

Neoplastic Reprogramming of Patient-Derived Adipose Stem Cells by Prostate Cancer Cell-Associated Exosomes [PDF]

Stem Cells, 2013
Abstract Emerging evidence suggests that mesenchymal stem cells (MSCs) are often recruited to tumor sites but their functional significance in tumor growth and disease progression remains elusive. Herein we report that prostate cancer (PC) cell microenvironment subverts PC patient adipose-derived stem cells (pASCs) to undergo neoplastic ...
Zakaria Y. Abd Elmageed, Yijun Yang, Raju Thomas, Manish Ranjan, Debasis Mondal, Krzysztof Moroz, Zhide Fang, Bashir M. Rezk, Krishnarao Moparty, Suresh C. Sikka, Oliver Sartor, Asim B. Abdel‐Mageed   +11 more
openalex   +4 more sources

Normal & neoplastic stem cell (ML15) [PDF]

International Immunology, 2010
Irving L. Weissman
openalex   +2 more sources

Thrombopoietin in normal and neoplastic stem cell development [PDF]

Best Practice & Research Clinical Haematology, 2009
It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia
Kenneth Kaushansky, Helen M. Ranney
openalex   +3 more sources

Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential [PDF]

The EMBO Journal, 2016
Aneuploidy leads to severe developmental defects in mammals and is also a hallmark of cancer. However, whether aneuploidy is a driving cause or a consequence of tumor formation remains controversial. Paradoxically, existing studies based on aneuploid yeast and mouse fibroblasts have shown that aneuploidy is usually detrimental to cellular fitness. Here,
Meili Zhang, Li Cheng, Yuyan Jia, Guang Liu, Cuiping Li, Shuhui Song, Allan Bradley, Yue Huang   +7 more
openalex   +3 more sources

Co-Transplantation of Bone Marrow-MSCs and Myogenic Stem/Progenitor Cells from Adult Donors Improves Muscle Function of Patients with Duchenne Muscular Dystrophy

Cells, 2020
Duchenne muscular dystrophy (DMD) is a genetic disorder associated with a progressive deficiency of dystrophin that leads to skeletal muscle degeneration.
Aleksandra Klimczak, Agnieszka Zimna, Agnieszka Malcher, Urszula Kozlowska, Katarzyna Futoma, Jaroslaw Czarnota, Pawel Kemnitz, Anna Bryl, Maciej Kurpisz   +8 more
doaj   +1 more source

Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

eLife, 2021
Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness.
Brian Spurlock, Danitra Parker, Malay Kumar Basu, Anita Hjelmeland, Sajina GC, Shanrun Liu, Gene P Siegal, Alan Gunter, Aida Moran, Kasturi Mitra   +9 more
doaj   +1 more source

Can supernatant from immortalized adipose tissue MSC replace cell therapy? An in vitro study in chronic wounds model

Stem Cell Research & Therapy, 2020
Background Mesenchymal stem cells (MSCs) secrete a cocktail of growth factors and cytokines, which could promote tissue regeneration and wound healing.
Honorata Kraskiewicz, Maria Paprocka, Aleksandra Bielawska-Pohl, Agnieszka Krawczenko, Kinga Panek, Judyta Kaczyńska, Agnieszka Szyposzyńska, Mateusz Psurski, Piotr Kuropka, Aleksandra Klimczak   +9 more
doaj   +1 more source