Results 1 to 10 of about 314,513 (244)

Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma. [PDF]

open access: greenMol Cell, 2022
Deforzh E   +14 more
europepmc   +3 more sources

Pleiotropic role of HSF1 in neoplastic transformation. [PDF]

open access: yesCurr Cancer Drug Targets, 2014
HSF1 (Heat Shock transcription Factor 1) is the main transcription factor activated in response to proteotoxic stress. Once activated, it induces an expression of heat shock proteins (HSPs) which enables cells to survive in suboptimal conditions. HSF1 could be also activated by altered kinase signaling characteristic for cancer cells, which is a ...
Vydra N, Toma A, Widlak W.
europepmc   +4 more sources

Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B. [PDF]

open access: goldSci Rep, 2019
Vishnubalaji R   +12 more
europepmc   +3 more sources

Clonal dynamics of progressive neoplastic transformation [PDF]

open access: yesProceedings of the National Academy of Sciences, 1999
In a recent study, we found that newly isolated clones of NIH 3T3 mouse cells undergo neoplastic transformation more readily than uncloned cultures from which they were derived. After eleven low-density passages (LDPs), most of the 29 clones produced lightly stained early-stage transformed foci when grown to confluence in a primary assay for ...
M, Chow, H, Rubin
openaire   +2 more sources

Neoplastic transformation in longstanding fistula-in-ano [PDF]

open access: yesPostgraduate Medical Journal, 1987
Summary A case in which an infiltrating mucinous carcinoma developed within a suprasphincteric fistula-in-ano is presented. The diagnosis was suspected on biopsy and confirmed by repeat biopsy. The clinical and histological features of this case establish with certainty that the carcinoma arose within the fistula and was not a secondary ...
G H, Welch, I G, Finlay
openaire   +2 more sources

Neoplastic Transformation by Notch Requires Nuclear Localization [PDF]

open access: yesMolecular and Cellular Biology, 2000
Notch proteins are plasma membrane-spanning receptors that mediate important cell fate decisions such as differentiation, proliferation, and apoptosis. The mechanism of Notch signaling remains poorly understood. However, it is clear that the Notch signaling pathway mediates its effects through intercellular contact between neighboring cells.
S, Jeffries, A J, Capobianco
openaire   +2 more sources

Actin isoforms and neoplastic transformation

open access: yesAdvances in molecular oncology, 2017
The cytoplasmic actins (β and γ) play crucial roles during key cellular processes like adhesion, migration, polarization and cytokinesis. The understanding of their specific underlying mechanisms would be of major relevance not only for fundamental research but also for clinical applications, since modulations of actin isoforms are directly or ...
V. B. Dugina   +3 more
openaire   +3 more sources

Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation [PDF]

open access: bronze, 2008
Christopher R. Weber   +4 more
openalex   +1 more source

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