Results 1 to 10 of about 380,743 (322)

Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence [PDF]

Scientific Reports, 2021
Much in vivo evidence indicates that cyclooxygenase-2 (COX-2) is deeply involved in tumorigenesis. Although it has been proposed that COX-2-derived pro-inflammatory prostanoids mediate the tumorigenic activity of COX-2, the tumorigenic mechanisms of COX ...
Hyeon Ju Lee, So Ra Kim, Yu-Jin Jung, Jeong A. Han   +3 more
doaj   +4 more sources

Investigation of early neoplastic transformation and premalignant biology using genetically engineered organoid models [PDF]

Computational and Structural Biotechnology Journal, 2022
Organoid modeling is a powerful, robust and efficient technology faithfully preserving physiological and pathological characteristics of tissues of origin.
Hua Zhao, Casey Collet, Dongzi Peng, Uttam K. Sinha, De-Chen Lin   +4 more
doaj   +2 more sources

Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation [PDF]

eLife, 2021
Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness.
Brian Spurlock, Danitra Parker, Malay Kumar Basu, Anita Hjelmeland, Sajina GC, Shanrun Liu, Gene P Siegal, Alan Gunter, Aida Moran, Kasturi Mitra   +9 more
doaj   +2 more sources

Gastric Hyperplastic Polyps: A Benign Entity? Analysis of Recurrence and Neoplastic Transformation in a Cohort Study [PDF]

GE: Portuguese Journal of Gastroenterology, 2021
Introduction: Hyperplastic polyps represent 30–93% of all gastric epithelial polyps. They are generally detected as innocuous incidental findings; however, they have a risk of neoplastic transformation and recurrence.
Mafalda João, Miguel Areia, Susana Alves, Luís Elvas, Filipe Taveira, Daniel Brito, Sandra Saraiva, Ana Teresa Cadime   +7 more
doaj   +2 more sources

Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation [PDF]

Nature Communications, 2023
The dysregulation of the m6A epitranscriptomic networks have been reported to contribute to the development of gliomas. Here, the authors utilize induced pluripotent stem cell-derived astrocytes with a p53 mutation and demonstrate that mutant p53 ...
An Xu, Mo Liu, Mo-Fan Huang, Yang Zhang, Ruifeng Hu, Julian A. Gingold, Ying Liu, Dandan Zhu, Chian-Shiu Chien, Wei-Chen Wang, Zian Liao, Fei Yuan, Chih-Wei Hsu, Jian Tu, Yao Yu, Taylor Rosen, Feng Xiong, Peilin Jia, Yi-Ping Yang, Danielle A. Bazer, Ya-Wen Chen, Wenbo Li, Chad D. Huff, Jay-Jiguang Zhu, Francesca Aguilo, Shih-Hwa Chiou, Nathan C. Boles, Chien-Chen Lai, Mien-Chie Hung, Zhongming Zhao, Eric L. Van Nostrand, Ruiying Zhao, Dung-Fang Lee   +32 more
doaj   +2 more sources

FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks [PDF]

Frontiers in Cell and Developmental Biology
PurposeFOS-like antigen 1 (FRA1), encoded by FOSL1, is an inducible subunit of the AP-1 transcription factor complex and regulates gene expression in response to proliferative and environmental cues.
Wuroud Al-Khayyat, Taylor Laframboise, Jessica Dougherty, Marc S. Mendonca, Douglas R. Boreham, Douglas R. Boreham, T. C. Tai, T. C. Tai, T. C. Tai, Christopher Thome, Christopher Thome, Christopher Thome, Sujeenthar Tharmalingam, Sujeenthar Tharmalingam, Sujeenthar Tharmalingam   +14 more
doaj   +2 more sources

Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation [PDF]

Nature Communications, 2021
The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D ...
Roser Vilarrasa-Blasi, Paula Soler-Vila, Núria Verdaguer-Dot, Núria Russiñol, Marco Di Stefano, Vicente Chapaprieta, Guillem Clot, Irene Farabella, Pol Cuscó, Marta Kulis, Xabier Agirre, Felipe Prosper, Renée Beekman, Silvia Beà, Dolors Colomer, Hendrik G. Stunnenberg, Ivo Gut, Elias Campo, Marc A. Marti-Renom, José Ignacio Martin-Subero   +19 more
doaj   +2 more sources

STING activation in TET2-mutated hematopoietic stem/progenitor cells contributes to the increased self-renewal and neoplastic transformation. [PDF]

Leukemia, 2023
Xie J, Sheng M, Rong S, Zhou D, Wang C, Wu W, Huang J, Sun Y, Wang Y, Chen P, Wu Y, Wang Y, Wang L, Zhou BO, Huang X, Walsh CP, Bohlander SK, Huang J, Wang X, Xu GL, Gao H, Shi Y.   +21 more
europepmc   +3 more sources

The Clinicopathological Features of Gastric Hyperplastic Polyps with Neoplastic Transformations: A Suggestion of Indication for Endoscopic Polypectomy

Gut and Liver, 2009
Background/AimsAlthough gastric hyperplastic polyps are usually considered as benign lesions, a low risk of carcinomatous conversion is currently recognized.
A-Reum Han, Chang Ohk Sung, Kyoung Mee Kim, Cheol-Keun Park, Byung‐Hoon Min, Jun Haeng Lee, Jin Yong Kim, Dong Kyung Chang, Young‐Ho Kim, Poong‐Lyul Rhee, Poong‐Lyul Rhee, Jae J. Kim   +11 more
doaj   +2 more sources

Genomic Loss and Epigenetic Silencing of the FOSL1 Tumor Suppressor Gene in Radiation-induced Neoplastic Transformation of Human CGL1 Cells Alters the Tumorigenic Phenotype In Vitro and In Vivo. [PDF]

Radiat Res, 2023
Pirkkanen J, Tharmalingam S, Thome C, Sinex HC, Benjamin LV, Losch AC, Borgmann AJ, Dhaemers RM, Gordon C, Boreham DR, Mendonca MS.   +10 more
europepmc   +3 more sources