Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma. [PDF]
Mol Cell, 2022 Deforzh E +14 more
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Pleiotropic role of HSF1 in neoplastic transformation. [PDF]
Curr Cancer Drug Targets, 2014 HSF1 (Heat Shock transcription Factor 1) is the main transcription factor activated in response to proteotoxic stress. Once activated, it induces an expression of heat shock proteins (HSPs) which enables cells to survive in suboptimal conditions. HSF1 could be also activated by altered kinase signaling characteristic for cancer cells, which is a ...
Vydra N, Toma A, Widlak W.
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Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B. [PDF]
Sci Rep, 2019 Vishnubalaji R +12 more
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Clonal dynamics of progressive neoplastic transformation [PDF]
Proceedings of the National Academy of Sciences, 1999 In a recent study, we found that newly isolated clones of NIH 3T3 mouse cells undergo neoplastic transformation more readily than uncloned cultures from which they were derived. After eleven low-density passages (LDPs), most of the 29 clones produced lightly stained early-stage transformed foci when grown to confluence in a primary assay for ...
M, Chow, H, Rubin
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Neoplastic transformation in longstanding fistula-in-ano [PDF]
Postgraduate Medical Journal, 1987 Summary A case in which an infiltrating mucinous carcinoma developed within a suprasphincteric fistula-in-ano is presented. The diagnosis was suspected on biopsy and confirmed by repeat biopsy. The clinical and histological features of this case establish with certainty that the carcinoma arose within the fistula and was not a secondary ...
G H, Welch, I G, Finlay
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Neoplastic Transformation by Notch Requires Nuclear Localization [PDF]
Molecular and Cellular Biology, 2000 Notch proteins are plasma membrane-spanning receptors that mediate important cell fate decisions such as differentiation, proliferation, and apoptosis. The mechanism of Notch signaling remains poorly understood. However, it is clear that the Notch signaling pathway mediates its effects through intercellular contact between neighboring cells.
S, Jeffries, A J, Capobianco
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Actin isoforms and neoplastic transformation
Advances in molecular oncology, 2017 The cytoplasmic actins (β and γ) play crucial roles during key cellular processes like adhesion, migration, polarization and cytokinesis. The understanding of their specific underlying mechanisms would be of major relevance not only for fundamental research but also for clinical applications, since modulations of actin isoforms are directly or ...
V. B. Dugina +3 more
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Supplementary Figure 1 from CDK1 Phosphorylation of YAP Promotes Mitotic Defects and Cell Motility and Is Essential for Neoplastic Transformation [PDF]
, 2023 Shuping Yang +6 more
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Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation [PDF]
, 2008 Christopher R. Weber +4 more
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