Results 1 to 10 of about 2,745,163 (176)

Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation [PDF]

Nature Communications, 2021
The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D ...
Roser Vilarrasa-Blasi, Paula Soler-Vila, Núria Verdaguer-Dot, Núria Russiñol, Marco Di Stefano, Vicente Chapaprieta, Guillem Clot, Irene Farabella, Pol Cuscó, Marta Kulis, Xabier Agirre, Felipe Prosper, Renée Beekman, Silvia Beà, Dolors Colomer, Hendrik G. Stunnenberg, Ivo Gut, Elias Campo, Marc A. Marti-Renom, José Ignacio Martin-Subero   +19 more
doaj   +3 more sources

Pleiotropic role of HSF1 in neoplastic transformation. [PDF]

Curr Cancer Drug Targets, 2014
HSF1 (Heat Shock transcription Factor 1) is the main transcription factor activated in response to proteotoxic stress. Once activated, it induces an expression of heat shock proteins (HSPs) which enables cells to survive in suboptimal conditions. HSF1 could be also activated by altered kinase signaling characteristic for cancer cells, which is a ...
Vydra N, Toma A, Widlak W.
europepmc   +5 more sources

Investigation of early neoplastic transformation and premalignant biology using genetically engineered organoid models [PDF]

Computational and Structural Biotechnology Journal, 2022
Organoid modeling is a powerful, robust and efficient technology faithfully preserving physiological and pathological characteristics of tissues of origin.
Hua Zhao, Casey Collet, Dongzi Peng, Uttam K. Sinha, De-Chen Lin   +4 more
doaj   +2 more sources

Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation [PDF]

eLife, 2021
Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness.
Brian Spurlock, Danitra Parker, Malay Kumar Basu, Anita Hjelmeland, Sajina GC, Shanrun Liu, Gene P Siegal, Alan Gunter, Aida Moran, Kasturi Mitra   +9 more
doaj   +2 more sources

Gastric Hyperplastic Polyps: A Benign Entity? Analysis of Recurrence and Neoplastic Transformation in a Cohort Study [PDF]

GE: Portuguese Journal of Gastroenterology, 2021
Introduction: Hyperplastic polyps represent 30–93% of all gastric epithelial polyps. They are generally detected as innocuous incidental findings; however, they have a risk of neoplastic transformation and recurrence.
Mafalda João, Miguel Areia, Susana Alves, Luís Elvas, Filipe Taveira, Daniel Brito, Sandra Saraiva, Ana Teresa Cadime   +7 more
doaj   +2 more sources

Risk factors and clinical correlates of neoplastic transformation in gastric hyperplastic polyps in Chinese patients. [PDF]

Sci Rep, 2020
Gastric hyperplastic polyps (GHPs) have a potential risk of neoplastic transformation, but the responsible mechanisms have not yet been established. We conducted a study involving 55 patients (33 female) who had undergone endoscopic or surgical resection
Hu H, Zhang Q, Chen G, Pritchard DM, Zhang S.   +4 more
europepmc   +2 more sources

Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation [PDF]

Nature Communications, 2023
The dysregulation of the m6A epitranscriptomic networks have been reported to contribute to the development of gliomas. Here, the authors utilize induced pluripotent stem cell-derived astrocytes with a p53 mutation and demonstrate that mutant p53 ...
An Xu, Mo Liu, Mo-Fan Huang, Yang Zhang, Ruifeng Hu, Julian A. Gingold, Ying Liu, Dandan Zhu, Chian-Shiu Chien, Wei-Chen Wang, Zian Liao, Fei Yuan, Chih-Wei Hsu, Jian Tu, Yao Yu, Taylor Rosen, Feng Xiong, Peilin Jia, Yi-Ping Yang, Danielle A. Bazer, Ya-Wen Chen, Wenbo Li, Chad D. Huff, Jay-Jiguang Zhu, Francesca Aguilo, Shih-Hwa Chiou, Nathan C. Boles, Chien-Chen Lai, Mien-Chie Hung, Zhongming Zhao, Eric L. Van Nostrand, Ruiying Zhao, Dung-Fang Lee   +32 more
doaj   +2 more sources

Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro

Marine Drugs, 2016
Guanidine alkaloids from sponges Monanchora spp. represent diverse bioactive compounds, however, the mechanisms underlying bioactivity are very poorly understood.
Sergey A. Dyshlovoy, Kseniya M. Tabakmakher, Jessica Hauschild, Regina K. Shchekaleva, Katharina Otte, Alla G. Guzii, Tatyana N. Makarieva, Ekaterina K. Kudryashova, Sergey N. Fedorov, Larisa K. Shubina, Carsten Bokemeyer, Friedemann Honecker, Valentin A. Stonik, Gunhild von Amsberg   +13 more
doaj   +2 more sources

KRAS mutation and epithelial-macrophage interplay in pancreatic neoplastic transformation. [PDF]

Int J Cancer, 2018
Pancreatic ductal adenocarcinoma (PDA) is characterized by epithelial mutations in KRAS and prominent tumor‐associated inflammation, including macrophage infiltration.
Bishehsari F, Zhang L, Barlass U, Preite NZ, Turturro S, Najor MS, Shetuni BB, Zayas JP, Mahdavinia M, Abukhdeir AM, Keshavarzian A.   +10 more
europepmc   +2 more sources

Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence [PDF]

Scientific Reports, 2021
Much in vivo evidence indicates that cyclooxygenase-2 (COX-2) is deeply involved in tumorigenesis. Although it has been proposed that COX-2-derived pro-inflammatory prostanoids mediate the tumorigenic activity of COX-2, the tumorigenic mechanisms of COX ...
Hyeon Ju Lee, So Ra Kim, Yu-Jin Jung, Jeong A. Han   +3 more
doaj   +2 more sources