Results 101 to 110 of about 331,839 (297)

Repair of neoplastic transformation damage following protracted exposures to /sup 60/Co. gamma. -rays

, 1983
The incidences of neoplastic transformation induced by /sup 60/Co ..gamma..-rays in exponentially growing mouse embryo 10T1/2 cells were measured following acute and protracted exposures. Delivery of /sup 60/Co ..gamma..-rays at a low dose rate (0.1, 0.5,
A. Han, Hill, C. K., Elkind, M. M., C.K. Hill, M.M. Elkind, Han, A.   +5 more
core   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Methylation Status of the Telomerase Reverse Transcriptase Promoter in Parotid Tumours and Adjacent Parotid Gland Tissue: A Pilot Study on the Implications for Recurrence and Development of Malignancy

Current Oncology
Background/Objectives: The methylation of the hypermethylated oncological region (THOR) of human telomerase reverse transcriptase (hTERT) may forecast tumour aggressiveness. This pilot study aimed to evaluate THOR methylation as a potential biomarker for
António Paiva-Correia, Joana Apolónio, Alfons Nadal, José Ricardo Brandão, Nádia Silva, Bianca Machado, Ivan Archilla, Pedro Castelo-Branco, Henrik Hellquist   +8 more
doaj   +1 more source

Adaptive response against spontaneous neoplastic transformation induced by low dose ionizing radiation [PDF]

, 2000
This project is being conducted to ascertain the shape of the dose response curve for neoplastic transformation in vitro over the dose range 0.0 to 10 cGy, and to determine how this depends on radiation quality and dose fractionation.
Redpath, J. Leslie
core   +1 more source

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

Genomics define neoplastic transformation in multiple myeloma precursor conditions

Background: Multiple myeloma (MM) is always preceded by monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). While these precursor conditions are asymptomatic, they are not entirely benign and carry a lifelong ...
Castellano, Giancarlo, de Magistris, Claudio, Siegel, Erin, Leongamornlert, Daniel, Teer, Jamie, Shain, Kenneth, Ziccheddu, Bachisio, Marella, Alessio, Baz, Rachid, McPherson, Andrew, Garces, Juan-Jose, Deavila, Daniel, Morgan, Gareth, Derkach, Andriy, Sudalagunta, Praneeth Reddy, Diamond, Benjamin, Campbell, Peter, Agius, Phaedra, Durante, Michael, Renatino Canevarolo, Rafael, Blaney, Patrick, Yamashita, Yusuke, Papadimitriou, Marios, Kumar, Shaji, Maeda, Akihiro, Fonseca, Rafael, Hultcrantz, Malin, Siqueira Silva, Ariosto, Landgren, Ola, Orlowski, Robert, Braggio, Esteban, Pioggia, Stefania, Rajkumar, Vincent, Matera, Antonio, Maura, Francesco, Asmann, Yan, Lionetti, Marta, Usmani, Saad, Da Vià, Matteo Claudio, Patel, Krina, Bergsagel, P. Leif, Firestone, Ross, Bolli, Niccolo, Maclachlan, Kylee   +43 more
core   +1 more source

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

Cytologic Manifestations of Neoplastic Transformation In Vitro 1

, 1969
SUMMARY-Our objective was to test whether cytologic diagnoses of neoplastic transformation could be made accurately on cultured cells in vitro. Cytologic criteria of malignancy as applied to tissues or exfoliated cells in vivo served as guidelines for ...
Barbara E. Barker, Katherine K. Sanford, Barker, B E, Sanford, K K   +3 more
core