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The cytology of spontaneous neoplastic transformation in culture
In Vitro, 1977Thirteen cell lines derived from embryos of the mouse, rat and hamster were sampled at closely spaced intervals for cytology and spontaneous neoplastic transformation. Transformation, determined by growth of the cells as malignant neoplasms in compatible hosts, occurred in eight lines and appeared to be unrelated to time in culture, passage number ...
S L, Handleman +3 more
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The Neoplastic Transformation of SCID Cells by Radiation
Radiation Research, 1999Severe combined immunodeficiency (SCID) cells are hypersensitive to killing by ionizing radiation because of deregulation of DNA-dependent protein kinase (DNA-PK) and a concomitant deficiency in the repair of DNA double-strand breaks. The effect of this condition on the neoplastic transformation of SCID fibroblasts, designated SCID 3T1, has been ...
M, Lun +4 more
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Neoplastic Cell Transformation by Heavy Ions
Radiation Research, 1989We have studied the induction of morphological transformation by heavy ions. Golden hamster embryo cells were irradiated with 95 MeV 14N ions (530 keV/microns), 22 MeV 4He ions (36 keV/microns), and 22 MeV 4He ions with a 100-microns Al absorber (77 keV/microns) which were generated by a cyclotron at the Institute of Physical and Chemical Research in ...
M, Suzuki +4 more
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Pulsed ultrasound and neoplastic transformation in vitro
Ultrasound in Medicine & Biology, 1991C3H/10T1/2 mouse embryo fibroblast cells grown as 1.2 cm diameter monolayers were assayed for cytotoxicity and neoplastic transformation following 30 min insonations with three types of pulsed ultrasound (US). Two of the US beams, with a repetition frequency of 1 kHz, center frequencies of 2.5 and 3.5 MHz and time-averaged intensities (ITA) of 31 and 6.
G H, Harrison, E K, Balcer-Kubiczek
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Mechanisms of neoplastic transformation.
Cancer investigation, 1984This paper introduces a series of invited essays on current controversies in basic cancer research. The initial group of essays focuses on the detection and interpretation of molecular and cellular changes suspected to be of importance in the cause and pathogenesis of cancer. There are two formats: (i) differing viewpoints are presented in parallel, or
R J, Monnat, L A, Loeb
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Angiogenesis and Neoplastic Transformation
1992The major symptom of the neoplastic diseases is the unrestrained growth of cell populations with formation in most cases of solid tumors. Passage of cells into circulation and metastases formation completes the lethal outcome of the disease. When an agglomerate of cells is being formed in vivo, the increment in volume is conditioned by the supply ...
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The role of selection in progressive neoplastic transformation
2001Mathematical modeling indicates that selective growth of cells with biallelic mutations in tumor suppressor genes is the driving force in the development of most human tumors, and that increased mutation rate is not required. Spontaneous neoplastic transformation of cells in culture offers the opportunity for quantitative analysis of all stages of ...
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Glycosaminoglycans and neoplastic transformation.
Anticancer research, 1983Two classes of mammalian glycosaminoglycans (GAGs) are distinguished: hyaluronic acid and chondroitin sulphate homopolymers, exhibiting identical repetitive building blocks, versus heparan and dermatan sulphate co-polymers, with differently substituted disaccharidic units.
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Neoplastic transformation in vitro.
Polish journal of pharmacology and pharmacy, 1980Oncogenic transformation of cultured cells is considered to be analogous to the induction of tumors in animals. Two properties of transformed cells: the capacity to grow in soft agar and morphological alterations were used as a basis for quantitative studies on the transforming properties of chemicals.
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Mutation and Neoplastic Transformation
Annals of the New York Academy of Sciences, 1988J C, Barrett +3 more
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