Results 21 to 30 of about 304,509 (373)
Frontiers in Pharmacology, 2022 The cytoplasmic actin isoforms (β- and γ-actins) contribute greatly to cellular processes such as cel-cell and cell-matrix interactions, as well as cell polarization, motility and division. Distinct isoforms modulations are linked to serious pathologies,
V. B. Dugina +3 more
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Functions of BLM Helicase in Cells: Is It Acting Like a Double-Edged Sword?
Frontiers in Genetics, 2021 DNA damage repair response is an important biological process involved in maintaining the fidelity of the genome in eukaryotes and prokaryotes. Several proteins that play a key role in this process have been identified.
Ekjot Kaur, Ritu Agrawal, Sagar Sengupta
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Cancer Medicine, 2022 Barrett's esophagus is a widespread chronically progressing disease of heterogeneous nature. A life threatening complication of this condition is neoplastic transformation, which is often overlooked due to lack of standardized approaches in diagnosis ...
Ksenia S. Maslyonkina +4 more
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An interpretable machine learning system for colorectal cancer diagnosis from pathology slides [PDF]
npj Precis. Onc. 8, 56 (2024), 2023 Considering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI). For this, we propose a deep learning (DL) system that learns from weak labels, a sampling strategy that reduces the number of training samples by a factor ...
arxiv +1 more source
Di-san junyi daxue xuebao, 2022 Objective To identify new human lung cancer suppressors in a genome-wide screening library during neoplastic transformation of normal human lung epithelial cells using CRISPR/Cas9-mediated genome editing, and preliminarily validate the Results in non ...
ZHAO Binyu +5 more
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Deep learning-based transformation of the H&E stain into special stains [PDF]
Nature Communications (2021), 2020 Pathology is practiced by visual inspection of histochemically stained slides. Most commonly, the hematoxylin and eosin (H&E) stain is used in the diagnostic workflow and it is the gold standard for cancer diagnosis. However, in many cases, especially for non-neoplastic diseases, additional "special stains" are used to provide different levels of ...
arxiv +1 more source
Actin isoforms and neoplastic transformation
Успехи молекулярной онкологии, 2017 The cytoplasmic actins (β and γ) play crucial roles during key cellular processes like adhesion, migration, polarization and cytokinesis. The understanding of their specific underlying mechanisms would be of major relevance not only for fundamental ...
V. B. Dugina +3 more
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The Neoplasia as embryological phenomenon and its implication in the animal evolution and the origin of cancer. I. A presentation of the neoplastic process and its connection with cell fusion and germline formation [PDF]
, 2022 The decisive role of Embryology in understanding the evolution of animal forms is founded and deeply rooted in the history of science. It is recognized that the emergence of multicellularity would not have been possible without the formation of the first embryo.
arxiv +1 more source
Emerging roles of telomeric chromatin alterations in cancer [PDF]
, 2019 Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria +2 more
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European Journal of Medical Research, 2010 The purpose of this report is to document a case of unsuspected ameloblastoma involving the right man dibular subpontic region in a 38-year-old Cambodian female patient. This lesion was purportedly preceded by multiple radiolucencies which were diagnosed
Siar CH +5 more
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