ATF2 promotes urothelial cancer outgrowth via cooperation with androgen receptor signaling
Endocrine Connections, 2018 We investigated the functional role of ATF2, a transcription factor normally activated via its phosphorylation in response to phospho-ERK/MAPK signals, in the outgrowth of urothelial cancer.
Satoshi Inoue +7 more
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Transcribed ultraconserved noncoding RNAs (T-UCR) are involved in Barrett's esophagus carcinogenesis. [PDF]
, 2014 Barretts esophagus (BE) involves a metaplastic replacement of native esophageal squamous epithelium (Sq) by columnar-intestinalized mucosa, and it is the main risk factor for Barrett-related adenocarcinoma (BAc).
Baffa, R +17 more
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Damages to DNA That Result in Neoplastic Transformation [PDF]
, 1975 Some topics discussed are: correlation between carcinogens and mutagens; defective DNA repair in uv-damaged xeroderma pigmentosum cells; analysis of nucleotide damage to DNA following exposure to chemicals or radiations; photoreactivation in uv-irradiated Escherichia coli; tumor development in fish; excision repair as an aid in identifying damage ...
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Marine Drugs, 2016 Guanidine alkaloids from sponges Monanchora spp. represent diverse bioactive compounds, however, the mechanisms underlying bioactivity are very poorly understood.
Sergey A. Dyshlovoy +13 more
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The Neoplasia as embryological phenomenon and its implication in the animal evolution and the origin of cancer. II. The neoplastic process as an evolutionary engine [PDF]
arXiv, 2022 In this article, I put forward the idea that the neoplastic process (NP) has deep evolutionary roots and make specific predictions about the connection between cancer and the formation of the first embryo, which allowed for the evolutionary radiation of metazoans.
arxiv
Direct reprogramming en route to neoplastic transformation [PDF]
Cell Cycle, 2013 Over the past years considerable effort has been directed toward identification of genes involved in cancer. We know now that mutations in more than 1% of human genes (out of ~20,000–25,000 genes in human genome) could play a role in cancer.1 Major advances have been made in understanding the processes involved in cancer progression.
Alice Nemajerova, Oleksi Petrenko
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Suppression of Neoplastic Transformation by Low Doses of Low Let Radiation
Dose-Response, 2006 A major concern of exposure to low doses of radiation is the risk of cancer induction. Epidemiologic data are rarely powerful enough to accurately discriminate this risk at doses
J. Leslie Redpath PhD
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EXOSOMES AND TRANSFER OF (EPI)GENETIC INFORMATION BY TUMOR CELLS
Успехи молекулярной онкологии, 2015 In this review, we will introduce the current knowledge about exosomes – vesicles that are generated in the cells and released into the extracellular space. Exosomes are forming in the cell plasma membrane and represent the spherical shapes restricted by
E. M. Tchevkina +5 more
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Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis. [PDF]
, 2015 Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic and inflammatory microenvironment that is formed primarily by activated, myofibroblast-like, stellate cells.
Dhall, Deepti +4 more
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Gut and Liver, 2009 Background/AimsAlthough gastric hyperplastic polyps are usually considered as benign lesions, a low risk of carcinomatous conversion is currently recognized.
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