Results 61 to 70 of about 331,839 (297)
Adaptive Response Against Spontaneous Neoplastic Transformation In Vitro Induced by Ionizing Radiation [PDF]
, 2002 response curve for radiation-induced neoplastic transformation of HeLa x skin fibroblast human hybrid cells in vitro under experimental conditions where an adaptive response, if it were induced, would have an opportunity to be expressed. During the first
Redpath, J. Leslie
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FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
"Transformation of chronic myelogenous leukemia to Multiple Myeloma: A case report " [PDF]
Acta Medica Iranica, 2003 Chronic myelogenous leukemia (CML) is a stem cell disorder sometimes associated with lymphoproliferative disorders. CML may precede a lymphoproliferative disorder.
"Ghavamzadeh A +5 more
doaj +1 more source
Microtubule Protein βIII-Tubulin: Structure, Expression and Functions in Normal and Tumor Cells
Антибиотики и Химиотерапия, 2020 The present review contains data on microtubular protein ßIII-tubulin (TUBB3): its structure, functions, role in tumor progression, expression in normal cells and in neural and epithelial tumors of different origins.
I. A. Mamichev +5 more
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EMBO Molecular Medicine, 2013 Initiating neoplastic cell transformation events are of paramount importance for the comprehension of regeneration and vanguard oncogenic processes but are difficult to characterize and frequently clinically overlooked.
Gonçalo Regalo, Achim Leutz
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Adaptive Response Against Spontaneous Neoplastic Transformation In Vitro Induced by Ionizing Radiation [PDF]
, 2003 The goal of this project was to establish a dose response curve for radiation-induced neoplastic transformation of HeLa x skin fibroblast human hybrid cells in vitro under experimental conditions were an adaptive response, if it were induced, would have ...
J. Leslie Redpath, Ph.D.
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann +17 more
wiley +1 more source
Alternative Splicing and Its Impact as a Cancer Diagnostic Marker [PDF]
Genomics & Informatics, 2012 Most genes are processed by alternative splicing for gene expression, resulting in the complexity of the transcriptome in eukaryotes. It allows a limited number of genes to encode various proteins with intricate functions.
Yun-Ji Kim, Heui-Soo Kim
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Expression of vascular endothelial growth factor in dogs with Spirocerca lupi-associated neoplastic transformation [PDF]
, 2012 Dissertation (MMedVet)--University of Pretoria, 2012.Tumour development is dependent upon the formation of an adequate blood supply through angiogenesis.
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