Results 61 to 70 of about 1,988,958 (283)
EMBO Molecular Medicine, 2013 Initiating neoplastic cell transformation events are of paramount importance for the comprehension of regeneration and vanguard oncogenic processes but are difficult to characterize and frequently clinically overlooked.
Gonçalo Regalo, Achim Leutz
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
MicroRNAs involved in neoplastic transformation of liver cancer stem cells
Journal of Experimental & Clinical Cancer Research, 2010 Background The existence of cancer stem cells in hepatocellular carcinoma (HCC) has been verified by characterizing side population (SP) cells based on efflux of Hoechst 33342 dye from stem cells. Recent advances in microRNA (miRNA) biology have revealed
Wang Xinchuan +5 more
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Alternative Splicing and Its Impact as a Cancer Diagnostic Marker [PDF]
Genomics & Informatics, 2012 Most genes are processed by alternative splicing for gene expression, resulting in the complexity of the transcriptome in eukaryotes. It allows a limited number of genes to encode various proteins with intricate functions.
Yun-Ji Kim, Heui-Soo Kim
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Mechanisms of radiation-induced neoplastic cell transformation [PDF]
, 1984 Studies with cultured mammalian cells demonstrated clearly that radiation can transform cells directly and can enhance the cell transformation by oncogenic DNA viruses.
C.A. Tobias +3 more
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FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
, 2023 The Technologies for African Agricultural Transformation (TAAT) Program was initiated by the African Development Bank (AfDB) as part of its Feed Africa Initiative.
Technologies for African Agricultural Transformation
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GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Revista Chilena de Obstetricia y Ginecología, 2006 Se presenta una revisión bibliográfica del mecanismo de infección y transformación neoplásica producida por el virus papiloma humano, de alto riesgo oncogénico, en el epitelio cervical.
René Rivera Z +4 more
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Microtubule Protein βIII-Tubulin: Structure, Expression and Functions in Normal and Tumor Cells
Антибиотики и Химиотерапия, 2020 The present review contains data on microtubular protein ßIII-tubulin (TUBB3): its structure, functions, role in tumor progression, expression in normal cells and in neural and epithelial tumors of different origins.
I. A. Mamichev +5 more
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