Results 1 to 10 of about 1,066,740 (345)

Lack of netrin-4 modulates pathologic neovascularization in the eye [PDF]

Scientific Reports, 2016
Netrins are a family of matrix-binding proteins that function as guidance signals. Netrin-4 displays pathologic roles in tumorigenesis and neovascularization.
Brunken, William J., Crespo-Garcia, Sergio, Joussen, Antonia M., Klein, Sabrina V., Koch, Manuel, Kociok, Norbert, Liang, Yong, Maier, Anna-Karina, Moritz, Eva, Nürnberg, Christina, Reichhart, Nadine, Skosyrski, Sergej, Strauß, Olaf   +12 more
core   +8 more sources

Factors associated with the recurrence of choroidal neovascularization in pathologic myopia [PDF]

Frontiers in Medicine, 2022
PurposeTo investigate the factors associated with the recurrence of pathologic myopia choroidal neovascularization (PM-CNV).MethodsForty-eight eyes of 48 patients with PM-CNV treated with conbercept at least 6 months of follow-up were included. Appearance of ellipsoid zone (EZ) and retinal pigment epithelium (RPE) observed on optical coherence ...
Ruixia Jing, Yuxia Bo, Lei Gao, Zhen Wang   +3 more
doaj   +9 more sources

Sirtuin1 Over-Expression Does Not Impact Retinal Vascular and Neuronal Degeneration in a Mouse Model of Oxygen-Induced Retinopathy [PDF]

PLoS ONE, 2014
Proliferative retinopathy is a leading cause of blindness, including retinopathy of prematurity (ROP) in children and diabetic retinopathy in adults. Retinopathy is characterized by an initial phase of vessel loss, leading to tissue ischemia and hypoxia,
Chen, Jing, Cui, Zhenghao, Evans, Lucy P., Hatton, Colman J., Hurst, Christian G., Ju, Meihua, Juan, Aimee M., Michan, Shaday, Pei, Dorothy T., Sinclair, David A., Smith, Lois E. H.   +10 more
core   +11 more sources

Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2019
Objective— Pathological neovascularization is crucial for progression and morbidity of serious diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. While mechanisms of ongoing pathological neovascularization have been extensively studied, the initiating pathological vascular remodeling (PVR ...
Anthony Mukwaya, Qiaolin Deng, Beatrice Bourghardt Peebo, Antje Biesemeier, Rickard Sandberg, Ulrich Schraermeyer, Claudia Gerri, Michele Marass, Julianna Kele, Anders Kvanta, Parviz Mammadzada, Luis del Peso, Luis del Peso, Daniel Ramsköld, Michael R. Taylor, Neil Lagali, Zaheer Ali, Camilla Hildesjö, Helder André, Anton Lennikov, Maria Ntzouni, Yihai Cao, Renhai Cao, John F. Steffensen, Lasse Jensen, Sarantis Giatrellis   +25 more
openaire   +8 more sources

ADAM9 Is Involved in Pathological Retinal Neovascularization [PDF]

Molecular and Cellular Biology, 2009
Pathological ocular neovascularization, caused by diabetic retinopathy, age-related macular degeneration, or retinopathy of prematurity, is a leading cause of blindness, yet much remains to be learned about its underlying causes. Here we used oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularization (CNV) to assess the ...
Peter A. Campochiaro, Steven L. Swendeman, Tsunehiko Yoshida, Carl P. Blobel, Carl P. Blobel, Victor H. Guaiquil, Sai H. Chavala   +6 more
openaire   +3 more sources

Interleukin-18 regulates pathological intraocular neovascularization [PDF]

Journal of Leukocyte Biology, 2007
AbstractRecently, the proinflammatory cytokine IL-18 has been shown to have a role in angiogenesis. This study aimed to elucidate its role in abnormal neovascularization (NV) in an oxygen-induced retinopathy (OIR) mouse model of the retinopathy seen in human premature newborns.
Yasuhiro Ikeda, Young Joon Jo, Yasuaki Hata, Yukio Sassa, Kuniaki Hijioka, Chikako Tsutsumi-Miyahara, Tatsuro Ishibashi, Shizuo Akira, Hong Qiao, Takeru Yoshimura, Koh Hei Sonoda   +10 more
openaire   +3 more sources

Potential Role for ADAM15 in Pathological Neovascularization in Mice [PDF]

Molecular and Cellular Biology, 2003
ADAM15 (named for a disintegrin and metalloprotease 15, metargidin) is a membrane-anchored glycoprotein that has been implicated in cell-cell or cell-matrix interactions and in the proteolysis of molecules on the cell surface or extracellular matrix.
Lawrence G. Lum, Klaus T. Preissner, Keisuke Horiuchi, Hans-Peter Hammes, Katia Manova, Thomas A. Brodie, Gisela Weskamp, Carl P. Blobel, Roland Baron, Roland Baron, Riccardo Chiusaroli, Riccardo Chiusaroli, Thomas Ludwig, Hui Cai   +13 more
openaire   +3 more sources

A Population-Based Ultra-Widefield Digital Image Grading Study for Age-Related Macular Degeneration-Like Lesions at the Peripheral Retina. [PDF]

, 2015
Our understanding of the relevance of peripheral retinal abnormalities to disease in general and in age-related macular degeneration (AMD) in particular is limited by the lack of detailed peripheral imaging studies.
Bird, AC, Csutak, A, Florea, D, Jonasson, F, Lengyel, I, Leung, I, Peto, T   +6 more
core   +1 more source

Lipid Mediators, M2 Macrophages, and Pathological Neovascularization [PDF]

Trends in Molecular Medicine, 2018
Sasaki and colleagues [1] (JCI Insight 2018;3,e96902) identified the leukocyte inflammatory lipid mediator leukotriene B4 (LTB4)/LTB4 receptor 1 receptor-signaling axis in M2 macrophages as a causal pathway for the vascular endothelial growth factor-dependent pathological neovascularization in a mouse model that mimics wet age-related macular ...
Timothy Hla, Steven L. Swendeman
openaire   +3 more sources

IDO1 is an Integral Mediator of Inflammatory Neovascularization. [PDF]

, 2016
The immune tolerogenic effects of IDO1 (indoleamine 2,3-dioxygenase 1) have been well documented and genetic studies in mice have clearly established the significance of IDO1 in tumor promotion.
Bravo-Nuevo, Arturo, DuHadaway, James B., Mondal, Arpita, Muller, Alexander J., Prendergast, George C., Smith, Courtney, Sutanto-Ward, Erika   +6 more
core   +3 more sources