Lack of netrin-4 modulates pathologic neovascularization in the eye [PDF]
Scientific Reports, 2016 AbstractNetrins are a family of matrix-binding proteins that function as guidance signals. Netrin-4 displays pathologic roles in tumorigenesis and neovascularization. To answer the question whether netrin-4 acts either pro- or anti-angiogenic, angiogenesis in the retina was assessed in Ntn-4−/− mice with oxygen-induced retinopathy (OIR) and laser ...
N. Kociok +12 more
semanticscholar +5 more sources
Factors associated with the recurrence of choroidal neovascularization in pathologic myopia [PDF]
Frontiers in Medicine, 2022 PurposeTo investigate the factors associated with the recurrence of pathologic myopia choroidal neovascularization (PM-CNV).MethodsForty-eight eyes of 48 patients with PM-CNV treated with conbercept at least 6 months of follow-up were included ...
Ruixia Jing +3 more
doaj +7 more sources
FGF2-induced STAT3 activation regulates pathologic neovascularization.
Experimental Eye Research, 2019 Cell-autonomous endothelial cell (EC) fibroblast growth factor receptor (FGFR) signaling through FGFR1/2 is essential for injury-induced wound vascularization and pathologic neovascularization as in blinding eye diseases such as age-related macular degeneration. Which FGF ligand(s) is critical in regulating angiogenesis is unknown.
Zhenyu Dong +6 more
semanticscholar +4 more sources
A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization
Cell Reports, 2019 Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states.
Paulina M. Wojnarowicz +32 more
doaj +2 more sources
MicroRNA-18a-5p Administration Suppresses Retinal Neovascularization by Targeting FGF1 and HIF1A
Frontiers in Pharmacology, 2020 Pathologic ocular neovascularization commonly results in visual impairment or even blindness in numerous fundus diseases, including proliferative diabetic retinopathy (PDR), retinopathy of prematurity (ROP), and age-related macular degeneration (AMD ...
Ji-Tian Guan +10 more
doaj +2 more sources
Conbercept for treatment of choroidal neovascularization secondary to pathologic myopia
Acta Ophthalmologica, 2018 between September 2015 and October 2017 in Tampere Eye Centre were collected from the electronic medical records. Eyes were divided into two groups: Group 1 treated during 1 September 2015–31 August 2016, and Group 2 during 1 November 2016–31 October ...
Ming Yan +4 more
semanticscholar +4 more sources
Apolipoprotein E2 and E3, but Not E4, Promote Retinal Pathologic Neovascularization.
Investigative Opthalmology & Visual Science, 2017 Purpose To determine the relationship between the different isoforms of apolipoprotein E (ApoE) and retinal neovascularization. Methods The concentrations of ApoE and VEGF in vitreous humor samples with either a macular hole (MH), or diabetic macular ...
Tomomi Masuda +9 more
semanticscholar +4 more sources
Ocular risk factors for choroidal neovascularization in pathologic myopia.
Investigative Opthalmology & Visual Science, 2010 UNLABELLED PURPOSE. To identify the risk factors for development of myopic choroidal neovascularization (mCNV), a major cause of visual impairment. METHODS. Enrolled in the study were 23 consecutive patients with bilateral high myopia (axial length, > or
Y. Ikuno, Y. Jo, T. Hamasaki, Y. Tano
semanticscholar +4 more sources
Mast cells promote choroidal neovascularization in a model of age-related macular degeneration [PDF]
Journal of Neuroinflammation‘Wet’ age-related macular degeneration (AMD) is characterized by pathologic choroidal neovascularization (CNV) that destroys central vision. Abundant evidence points to inflammation and immune cell dysfunction in the progression of CNV in AMD. Mast cells
Rabah Dabouz +3 more
doaj +2 more sources
Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading ...
Thaís Heinke +3 more
doaj +3 more sources