Communications Medicine, 2021 Lee et al. use an antibody-drug conjugate to treat pathologic ocular neovascularization in mouse models. The antibody-drug conjugate targets PDGFRβ-expressing pericytes, with similar therapeutic effects to an anti-VEGF agent and with limited unwanted ...
Seok Jae Lee +10 more
doaj +2 more sources
A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization
Cell Reports, 2019 Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states.
Paulina M. Wojnarowicz +32 more
doaj +2 more sources
Lack of netrin-4 modulates pathologic neovascularization in the eye [PDF]
Scientific Reports, 2016 Netrins are a family of matrix-binding proteins that function as guidance signals. Netrin-4 displays pathologic roles in tumorigenesis and neovascularization.
N. Kociok +12 more
semanticscholar +3 more sources
FGF2-induced STAT3 activation regulates pathologic neovascularization
Experimental Eye Research, 2019 Cell-autonomous endothelial cell (EC) fibroblast growth factor receptor (FGFR) signaling through FGFR1/2 is essential for injury-induced wound vascularization and pathologic neovascularization as in blinding eye diseases such as age-related macular ...
Zhenyu Dong +6 more
semanticscholar +4 more sources
MicroRNA-18a-5p Administration Suppresses Retinal Neovascularization by Targeting FGF1 and HIF1A
Frontiers in Pharmacology, 2020 Pathologic ocular neovascularization commonly results in visual impairment or even blindness in numerous fundus diseases, including proliferative diabetic retinopathy (PDR), retinopathy of prematurity (ROP), and age-related macular degeneration (AMD ...
Ji-Tian Guan +10 more
doaj +2 more sources
Macrophage Sult2b1 promotes pathological neovascularization in age-related macular degeneration
Life Science Alliance, 2023 Sult2b1 deficiency attenuates pathologic neovascularization by inhibiting M2 macrophage polarization and promoting cholesterol efflux via the LXR–ABCA1/G1 pathway. Disordered immune responses and cholesterol metabolism have been implicated in age-related
Yafang Wang +8 more
doaj +2 more sources
Factors associated with the recurrence of choroidal neovascularization in pathologic myopia
Frontiers in Medicine, 2022 PurposeTo investigate the factors associated with the recurrence of pathologic myopia choroidal neovascularization (PM-CNV).MethodsForty-eight eyes of 48 patients with PM-CNV treated with conbercept at least 6 months of follow-up were included ...
Ruixia Jing +3 more
doaj +3 more sources
Ocular risk factors for choroidal neovascularization in pathologic myopia.
Investigative Opthalmology & Visual Science, 2010 PURPOSE. To identify the risk factors for development of myopic choroidal neovascularization (mCNV), a major cause of visual impairment. METHODS. Enrolled in the study were 23 consecutive patients with bilateral high myopia (axial length, > or =26.5 mm or refractive error, < or =8 D) and unilateral newly developed mCNV who presented to the Myopia ...
Y. Ikuno, Y. Jo, T. Hamasaki, Y. Tano
semanticscholar +3 more sources
INTRAVITREAL RANIBIZUMAB FOR CHOROIDAL NEOVASCULARIZATION COMPLICATING PATHOLOGIC MYOPIA
Retina, 2010 Purpose: The purpose of this study was to evaluate the efficacy of intravitreal injections of ranibizumab in choroidal neovascularization secondary to pathologic myopia. Methods: A prospective case series of 32 eyes of 32 patients affected with choroidal
F. Lalloum +7 more
semanticscholar +4 more sources
Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading ...
Thaís Heinke +3 more
doaj +3 more sources