Results 1 to 10 of about 34,395 (192)

Lack of netrin-4 modulates pathologic neovascularization in the eye [PDF]

Scientific Reports, 2016
Netrins are a family of matrix-binding proteins that function as guidance signals. Netrin-4 displays pathologic roles in tumorigenesis and neovascularization.
Brunken, William J., Crespo-Garcia, Sergio, Joussen, Antonia M., Klein, Sabrina V., Koch, Manuel, Kociok, Norbert, Liang, Yong, Maier, Anna-Karina, Moritz, Eva, Nürnberg, Christina, Reichhart, Nadine, Skosyrski, Sergej, Strauß, Olaf   +12 more
core   +6 more sources

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization [PDF]

Cell Reports, 2019
Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states.
Paulina M. Wojnarowicz, Raquel Lima e Silva, Masayuki Ohnaka, Sang Bae Lee, Yvette Chin, Anita Kulukian, Sung-Hee Chang, Bina Desai, Marta Garcia Escolano, Riddhi Shah, Marta Garcia-Cao, Sijia Xu, Rashmi Kadam, Yehuda Goldgur, Meredith A. Miller, Ouathek Ouerfelli, Guangli Yang, Tsutomu Arakawa, Steven K. Albanese, William A. Garland, Glenn Stoller, Jaideep Chaudhary, Larry Norton, Rajesh Kumar Soni, John Philip, Ronald C. Hendrickson, Antonio Iavarone, Andrew J. Dannenberg, John D. Chodera, Nikola Pavletich, Anna Lasorella, Peter A. Campochiaro, Robert Benezra   +32 more
doaj   +3 more sources

Macrophage Sult2b1 promotes pathological neovascularization in age-related macular degeneration

Life Science Alliance, 2023
Sult2b1 deficiency attenuates pathologic neovascularization by inhibiting M2 macrophage polarization and promoting cholesterol efflux via the LXR–ABCA1/G1 pathway. Disordered immune responses and cholesterol metabolism have been implicated in age-related
Yafang Wang, Yang Liu, Yan Wang, Yidong Wu, Zhixuan Chen, Feng Wang, Xiaoling Wan, Fenghua Wang, Xiaodong Sun   +8 more
doaj   +3 more sources

Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors [PDF]

Acta Cirúrgica Brasileira, 2013
PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading ...
Thaís Heinke, Kleber Simões do Espiríto Santo, Adhemar Longatto Filho, João Norberto Stavale   +3 more
doaj   +3 more sources

Topical Nanoemulsion of a Runt-related Transcription Factor 1 Inhibitor for the Treatment of Pathologic Ocular Angiogenesis

Ophthalmology Science, 2022
Purpose: To test the efficacy of runt-related transcription factor 1 (RUNX1) inhibition with topical nanoemulsion containing Ro5-3335 (eNano-Ro5) in experimental ocular neovascularization. Design: Preclinical experimental study.
Santiago Delgado-Tirado, MD, Lucia Gonzalez-Buendia, MD, Miranda An, BA, Dhanesh Amarnani, MS, Daniela Isaacs-Bernal, BSc, Hannah Whitmore, PhD, Said Arevalo-Alquichire, PhD, David Leyton-Cifuentes, BME, Jose M. Ruiz-Moreno, MD, PhD, Joseph F. Arboleda-Velasquez, MD, PhD, Leo A. Kim, MD, PhD   +10 more
doaj   +1 more source

Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2019
Objective— Pathological neovascularization is crucial for progression and morbidity of serious diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. While mechanisms of ongoing pathological neovascularization have been extensively studied, the initiating pathological vascular remodeling (PVR ...
Ali, Zaheer, Mukwaya, Anthony, Biesemeier, Antje, Ntzouni, Maria, Ramsköld, Daniel, Giatrellis, Sarantis, Mammadzada, Parviz, Cao, Renhai, Lennikov, Anton, Marass, Michele, Gerri, Claudia, Hildesjö, Camilla, Taylor, Michael, Deng, Qiaolin, Peebo, Beatrice, del Peso, Luis, Kvanta, Anders, Sandberg, Rickard, Schraermeyer, Ulrich, Andre, Helder, Steffensen, John F., Lagali, Neil, Cao, Yihai, Kele, Julianna, Jensen, Lasse Dahl   +24 more
openaire   +8 more sources

Correlation between the expression of vegf and survival in osteosarcoma [PDF]

Acta Ortopédica Brasileira, 2014
Objective: To present a series of 50 consecutive patients with non-metastatic extremity osteosarcoma, and attempt to correlate expression of the vascular endothelial growth factor (VEGF) protein in biopsy tissue to their prognosis regarding overall ...
André Mathias Baptista, André Ferrari De França Camargo, Renée Zon Filippi, Cláudia Regina Gomes Cardim Mendes De Oliveira, Raymundo Soares De Azevedo Neto, Olavo Pires De Camargo   +5 more
doaj   +1 more source

Interleukin-18 regulates pathological intraocular neovascularization [PDF]

Journal of Leukocyte Biology, 2007
AbstractRecently, the proinflammatory cytokine IL-18 has been shown to have a role in angiogenesis. This study aimed to elucidate its role in abnormal neovascularization (NV) in an oxygen-induced retinopathy (OIR) mouse model of the retinopathy seen in human premature newborns.
Hong, Qiao, Koh-Hei, Sonoda, Yasuhiro, Ikeda, Takeru, Yoshimura, Kuniaki, Hijioka, Young-Joon, Jo, Yukio, Sassa, Chikako, Tsutsumi-Miyahara, Yasuaki, Hata, Shizuo, Akira, Tatsuro, Ishibashi   +10 more
openaire   +2 more sources

Pathological Investigation of Congenital Bicuspid Aortic Valve Stenosis, Compared with Atherosclerotic Tricuspid Aortic Valve Stenosis and Congenital Bicuspid Aortic Valve Regurgitation [PDF]

, 2016
Congenital bicuspid aortic valve (CBAV) is the main cause of aortic stenosis (AS) in young adults. However, the histopathological features of AS in patients with CBAV have not been fully investigated.We examined specimens of aortic valve leaflets ...
A Mazzone, A Vahanian, BA Warren, BF Stewart, C Ward, CA Simmons, D Aicher, ER Mohler 3rd, H Akahori, H Furukawa, Hatsue Ishibashi-Ueda, Hideaki Kanzaki, J Satta, JA Kennedy, Junjiro Kobayashi, K Imanaka-Yoshida, Katherine Yutzey, KL Chan, LJ Olson, M Lindroos, N Cote, N Shimojo, PR Moreno, R Wang, RA Nishimura, RF Ankeny, RM Weiss, RN El Accaoui, Satoshi Yasuda, SC Siu, SH Goldbarg, SM Fernandes, T Nishioka, T Yokokawa, TC Lee, Tomoyuki Fujita, Toshihisa Anzai, Toshiyuki Nagai, Y Soini, Yasuhiro Hamatani, Yasuo Sugano   +40 more
core   +6 more sources

MicroRNA-18a-5p Administration Suppresses Retinal Neovascularization by Targeting FGF1 and HIF1A

Frontiers in Pharmacology, 2020
Pathologic ocular neovascularization commonly results in visual impairment or even blindness in numerous fundus diseases, including proliferative diabetic retinopathy (PDR), retinopathy of prematurity (ROP), and age-related macular degeneration (AMD ...
Ji-Tian Guan, Xin-Xin Li, De-Wei Peng, Wen-Meng Zhang, Jia Qu, Fan Lu, Fan Lu, Robert J. D’Amato, Robert J. D’Amato, Zai-Long Chi, Zai-Long Chi   +10 more
doaj   +1 more source