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The Emerging Role of Complement Proteins as a Target for Therapy of IgA Nephropathy
Frontiers in Immunology, 2019 IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is necessary for diagnosis, with routine immunofluorescence microscopy revealing dominant ...
Dana V Rizk +2 more
exaly +2 more sources
Loss of Farnesoid X receptor (FXR) accelerates dysregulated glucose and renal injury in db/db mice [PDF]
PeerJ, 2023 Background End-stage renal disease is primarily caused by diabetic kidney disease (DKD). The Farnesoid X receptor (FXR), a member of the nuclear receptor superfamily, has anti-inflammatory, lipid-lowering and hypoglycemic properties.
Yuxiang Qiu +6 more
doaj +2 more sources
Coagulation Function and Type 2 Diabetic Kidney Disease: A Real-World Observational Study
Journal of Diabetes Research, 2023 Objectives. Type 2 diabetic kidney disease (DKD), a chronic microvascular complication of diabetes, may exhibit a complex interrelation with coagulation function.
Meng-chao Liu +11 more
doaj +1 more source
Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment
BioMed Research International, 2021 Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide. Chronic hyperglycemia and high blood pressure are the main risk factors for the development of DN.
Nur Samsu
semanticscholar +1 more source
lncRNA MALAT1 Promotes Diabetic Nephropathy Progression via miR-15b-5p/TLR4 Signaling Axis
Journal of Immunology Research, 2022 Objective. The long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) are closely associated with the pathogenesis of diabetic nephropathy (DN). But a complete mechanism for MALAT1 in DN has yet to be identified.
Zijun Yang +3 more
doaj +1 more source
Journal of Diabetes Research, 2022 Shenlian (SL) decoction is a herbal formula composed of Coptis and ginseng, of which berberine and ginsenoside are the main constituents. Even though SL decoction is widely used in treating diabetes in China, the mechanism of its antidiabetes function ...
Rui-xi Sun +11 more
doaj +1 more source
Renal Failure, 2021 Purpose To identify the clinical characteristics, histopathological features, and prognosis of kidney disease in a large cohort of elderly patients from Northeast China. Methods We retrospectively analyzed the renal disease spectrum in 7,122 patients who
Ping Nie +7 more
doaj +1 more source
IgA Nephropathy: Core Curriculum 2021.
American Journal of Kidney Diseases, 2021 Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide. The diagnostic histologic hallmark is dominant or codominant IgA staining on kidney biopsy; however, patients may present with various clinical syndromes ranging
P. Pattrapornpisut +2 more
semanticscholar +1 more source
Nutrition & Diabetes, 2022 Objective We investigated the correlation between zinc levels and Nrf2 expression and potential effects on the clinicopathology of patients with diabetic nephropathy (DN).
Ping Nie +7 more
doaj +1 more source
Journal of Biological Engineering, 2022 Diabetic nephropathy, a kidney complication arising from diabetes, is the leading cause of death in diabetic patients. Unabated, the growing epidemic of diabetes is increasing instances of diabetic nephropathy.
H. Y. Thomas, Ashlee N. Ford Versypt
semanticscholar +1 more source