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Nature Reviews Disease Primers, 2021 Membranous nephropathy (MN) is a glomerular disease that can occur at all ages. In adults, it is the most frequent cause of nephrotic syndrome. In ~80% of patients, there is no underlying cause of MN (primary MN) and the remaining cases are associated with medications or other diseases such as systemic lupus erythematosus, hepatitis virus infection or ...
Ronco, Pierre +9 more
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The Crystalline Nephropathies [PDF]
Kidney International Reports, 2021 Crystalline nephropathies are a unique form of kidney disease characterized by the histologic finding of intrarenal crystal deposition. The intrinsic nature of some molecules and ions combined with a favorable tubular fluid physiology leads to crystal precipitation and deposition within the tubular lumens.
Leal Herlitz +2 more
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Loss of Farnesoid X receptor (FXR) accelerates dysregulated glucose and renal injury in db/db mice [PDF]
PeerJ, 2023 Background End-stage renal disease is primarily caused by diabetic kidney disease (DKD). The Farnesoid X receptor (FXR), a member of the nuclear receptor superfamily, has anti-inflammatory, lipid-lowering and hypoglycemic properties.
Yuxiang Qiu +6 more
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Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]
, 2017 IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna +11 more
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International Journal of Environmental Research and Public Health, 2022 The complex interaction between cardiac and renal functions is known. However, when these functions are disrupted, many intricate and sensitive interactions between these organs are failed by several pathophysiological ways. As a result, this malfunction is clinically evident by sign and symptoms associated to intravascular and interstitial congestion.
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Coagulation Function and Type 2 Diabetic Kidney Disease: A Real-World Observational Study
Journal of Diabetes Research, 2023 Objectives. Type 2 diabetic kidney disease (DKD), a chronic microvascular complication of diabetes, may exhibit a complex interrelation with coagulation function.
Meng-chao Liu +11 more
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lncRNA MALAT1 Promotes Diabetic Nephropathy Progression via miR-15b-5p/TLR4 Signaling Axis
Journal of Immunology Research, 2022 Objective. The long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) are closely associated with the pathogenesis of diabetic nephropathy (DN). But a complete mechanism for MALAT1 in DN has yet to be identified.
Zijun Yang +3 more
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Journal of the Royal College of Physicians of London, 1997 link_to_subscribed_fulltext
Simon C Satchell, Peter W Mathieson
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Journal of Diabetes Research, 2022 Shenlian (SL) decoction is a herbal formula composed of Coptis and ginseng, of which berberine and ginsenoside are the main constituents. Even though SL decoction is widely used in treating diabetes in China, the mechanism of its antidiabetes function ...
Rui-xi Sun +11 more
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Diabetology & Metabolic Syndrome, 2009 Diabetic nephropathy is the leading cause of chronic renal disease and a major cause of cardiovascular mortality. Diabetic nephropathy has been categorized into stages: microalbuminuria and macroalbuminuria. The cut-off values of micro- and macroalbuminuria are arbitrary and their values have been questioned.
Jorge Dias de Matos +5 more
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