Results 1 to 10 of about 481,070 (386)

Rituximab or cyclosporine in the treatment of membranous nephropathy [PDF]

New England Journal of Medicine, 2019
BACKGROUND B-cell anomalies play a role in the pathogenesis of membranous nephropathy. B-cell depletion with rituximab may therefore be noninferior to treatment with cyclosporine for inducing and maintaining a complete or partial remission of proteinuria
al., et, Li, Tingting
core   +3 more sources

Exostosin 1/exostosin 2-associated membranous nephropathy in undifferentiated connective tissue disease: a case report and literature review [PDF]

BMC Nephrology
Background Renal involvement in undifferentiated connective tissue disease (UCTD) is rare and not well characterized, with membranous nephropathy (MN) representing an uncommon but clinically significant manifestation. While exostosin 1/exostosin 2 (EXT 1/
Huan Ye, Xinxin Jiang, Binbin Wu, Xiaohui Xie, Zhigui Zheng   +4 more
doaj   +2 more sources

Long-Term Outcomes in IgA Nephropathy

American Society of Nephrology. Clinical Journal, 2023
Visual Abstract Background IgA nephropathy can progress to kidney failure, and risk assessment soon after diagnosis has advantages both for clinical management and the development of new therapeutics.
D. Pitcher, Fiona Braddon, Bruce Hendry, A. Mercer, Kate Osmaston, M. Saleem, R. Steenkamp, K. Wong, A. Turner, Kaijun Wang, D. Gale, J. Barratt   +11 more
semanticscholar   +1 more source

Loss of Farnesoid X receptor (FXR) accelerates dysregulated glucose and renal injury in db/db mice [PDF]

PeerJ, 2023
Background End-stage renal disease is primarily caused by diabetic kidney disease (DKD). The Farnesoid X receptor (FXR), a member of the nuclear receptor superfamily, has anti-inflammatory, lipid-lowering and hypoglycemic properties.
Yuxiang Qiu, Ningsu Kang, Xi Wang, Yao Yao, Jun Cui, Xiaoyan Zhang, Lu Zheng   +6 more
doaj   +2 more sources

Coagulation Function and Type 2 Diabetic Kidney Disease: A Real-World Observational Study

Journal of Diabetes Research, 2023
Objectives. Type 2 diabetic kidney disease (DKD), a chronic microvascular complication of diabetes, may exhibit a complex interrelation with coagulation function.
Meng-chao Liu, Wen-quan Niu, Yue-fen Wang, Yuan Meng, Gui-min Zheng, Zhen Cai, Cun Shen, Xiang-gang Zhu, Meng-di Wang, Jia-lin Li, Wen-jing Zhao, Yao-xian Wang   +11 more
doaj   +1 more source

Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice

Nature Communications, 2023
Statins play an important role in the treatment of diabetic nephropathy. Increasing attention has been given to the relationship between statins and insulin resistance, but many randomized controlled trials confirm that the therapeutic effects of statins
Tong-sheng Huang, Teng Wu, Yandi Wu, Xinghui Li, Jing Tan, Cong-hui Shen, Shiquin Xiong, Zi-qi Feng, Sai-fei Gao, Hui Li, W. Cai   +10 more
semanticscholar   +1 more source

lncRNA MALAT1 Promotes Diabetic Nephropathy Progression via miR-15b-5p/TLR4 Signaling Axis

Journal of Immunology Research, 2022
Objective. The long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) are closely associated with the pathogenesis of diabetic nephropathy (DN). But a complete mechanism for MALAT1 in DN has yet to be identified.
Zijun Yang, Dongxu Song, Yulin Wang, Lin Tang   +3 more
doaj   +1 more source

Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment

BioMed Research International, 2021
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide. Chronic hyperglycemia and high blood pressure are the main risk factors for the development of DN.
Nur Samsu
semanticscholar   +1 more source

Shenlian (SL) Decoction, a Traditional Chinese Medicine Compound, May Ameliorate Blood Glucose via Mediating the Gut Microbiota in db/db Mice

Journal of Diabetes Research, 2022
Shenlian (SL) decoction is a herbal formula composed of Coptis and ginseng, of which berberine and ginsenoside are the main constituents. Even though SL decoction is widely used in treating diabetes in China, the mechanism of its antidiabetes function ...
Rui-xi Sun, Wei-jun Huang, Yao Xiao, Dou-dou Wang, Guo-hua Mu, He Nan, Bo-ran Ni, Xiao-qiang Huang, Hsuan-chuan Wang, Yi-fan Liu, Qiang Fu, Jin-xi Zhao   +11 more
doaj   +1 more source

Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]

, 2017
IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna, Delles, Christian, Filip, Szymon, Gakiopoulou, Chara, Jankowski, Joachim, Krochmal, Magdalena, Markoska, Katerina, Mischak, Harald, Orange, Clare, Spasovski, Goce, Vlahou, Antonia, Zoidakis, Jerome   +11 more
core   +5 more sources