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Update on Diabetic Nephropathy: Core Curriculum 2018.
Diabetic kidney disease and diabetic nephropathy are the leading cause of end-stage kidney disease in the United States and most developed countries. Diabetes accounts for 30% to 50% of the incident cases of end-stage kidney disease in the United States.
K. Umanath, J. Lewis
semanticscholar +1 more source
Inflammatory Targets in Diabetic Nephropathy
One of the most frequent complications in patients with diabetes mellitus is diabetic nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and the main cause of cardiovascular morbidity and mortality in these patients.
J. Donate-Correa+8 more
semanticscholar +1 more source
Urine metabolomic analysis to detect metabolites associated with the development of contrast induced nephropathy. [PDF]
ObjectiveContrast induced nephropathy (CIN) is a result of injury to the proximal tubules. The incidence of CIN is around 11% for imaging done in the acute care setting.
Diercks, Deborah B+3 more
core +1 more source
Perspectives on the News commentaries are part of a free monthly CME activity. The Mount Sinai School of Medicine, New York, New York, designates this activity for 2.0 AMA PRA Category 1 credits. If you wish to participate, review this article and visit www.diabetes.procampus.net to complete a posttest and receive a certificate.
openaire +9 more sources
APOL1 Nephropathy: From Genetics to Clinical Applications.
Rates of many types of severe kidney disease are much higher in blacks than most other groups. Much of this disparity can now be attributed to genetic variants in the apoL1 (APOL1) gene found only in individuals with recent African ancestry.
D. Friedman, M. Pollak
semanticscholar +1 more source
Long-term glycemic variability and risk of adverse outcomes: a systematic review and meta-analysis [PDF]
OBJECTIVE: Glycemic variability is emerging as a measure of glycemic control, which may be a reliable predictor of complications. This systematic review and meta-analysis evaluates the association between HbA1c variability and micro- and macrovascular ...
Catherine Gorst+18 more
core +1 more source
Critical Role of Cysteine-Rich Protein 61 in Mediating the Activation of Renal Fibroblasts
ObjectiveTo explore the expression of cysteine-rich protein 61 (Cyr61) in ischemic renal fibrosis and the role of Cyr61 in mediating the activation of renal fibroblasts.Methods(1) The rat model of renal fibrosis was established after ischemia-reperfusion
Hang Liu+10 more
doaj +1 more source
New 'Antigens' in Membranous Nephropathy.
Membranous nephropathy (MN) occurs due to deposition of immune complexes along the subepithelial region of glomerular basement membrane. Two previously identified target antigens for the immune complexes, PLA2R (identified in 2009) and THSD7A (in 2014 ...
S. Sethi
semanticscholar +1 more source
Previous studies demonstrated that cGAS pathway is related to the inflammation amplification in a variety of autoimmune diseases. Lysine acetyltransferase family (KATs) can regulate the nuclear transcription or cytoplasmic activation of cGAS through ...
Youzhou Tang+8 more
doaj +1 more source
Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease
Necroptosis was elevated in both tubulointerstitial and glomerular renal tissue in patients with diabetic kidney disease (DKD), and was most pronounced on glomerulus in the stage with macroalbuminuria. This study further explored whether paeoniflorin (PF)
Xian Wang+8 more
doaj +1 more source