Results 191 to 200 of about 15,009 (224)
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[Nephroprotection, fact or fiction?].
Presse medicale (Paris, France : 1983), 2011Clinical studies of the last 15 years have shown the benefit of pharmacological interventions on the progression of chronic kidney disease, confirming the concept of nephroprotection. Pharmacological blockade of the renin angiotensin system remains the cornerstone of the nephroprotective treatment but the benefits and limitations are now better defined.
Thierry, Krummel +3 more
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[New aspects of pharmacological nephroprotection].
Innere Medizin (Heidelberg, Germany), 2022Current estimates forecast that chronic kidney diseases will be the fifth most common cause of death worldwide by 2040. The prevalence of chronic renal diseases increases with age and, in many countries, affects patients with overweight, diabetes and hypertension.
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Dual renin–angiotensin system blockade for nephroprotection
Néphrologie & Thérapeutique, 2017In experimental diabetic and nondiabetic chronic kidney disease, angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blockers (ARB) combination therapy reduce proteinuria and prevent structural lesions more effectively than either drug alone.
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NEPHROPROTECTIVE AND HEPATOPROTECTIVE EFFECTS OF CURCUMINOIDS
2007Curcumin (U1) has a wide spectrum of therapeutic effects such as antitumor and anti-inflammatory effects, including antibacterial, antiviral, antifungal, and antispasmodic activities. By comparison of the structure-activity relationship, tetrahydrocurcumin (THU1), one of the major metabolites, showed the highest antioxidative activity in both in vitro ...
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Candesartan: Nephroprotective effects and treatment of diabetic nephropathy
Drugs of Today, 2003Candesartan shows beneficial end-organ effects in the kidney. Some of these appear to be related not to the reduction in systemic blood pressure induced by candesartan, but to its blockage of intrarenal angiotensin II type I (AT1) receptors. Initial studies have shown that renal vascular resistance was reduced in patients with hypertension receiving ...
Albert, Mimran, Vicente, Alfaro
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Nephroprotective: A Comprehensive Review
Waste filtration, electrolyte balancing, blood pressure management, hormone generation, and acid-base maintenance are just a few of the vital roles the kidneys play in preserving general health. Nephrotoxicity, which can result in diseases like acute kidney injury (AKI) and chronic kidney disease (CKD), is the term used to describe kidney damage ...openaire +1 more source
[Mechanisms of statin nephroprotective actions].
Przeglad lekarski, 2003The great importance of HMGCoA reductase inhibitors (statins) in treatment of hyperlipidemia is well known, and accepted. Numerous multicenter trials have shown the effectiveness of statins in lowering cholesterol concentration, slowing down progression of atherosclerosis, and in decreasing number of cardio-vascular incidents.
Michał, Chmielewski +2 more
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Calcium channel blockers and nephroprotection.
Aging clinical and experimental research, 2005The prevalence and incidence of End-Stage Renal Disease (ESRD) have progressively increased in the last 20 years. Hypertension and diabetes are the two most important causes of ESRD, and antihypertensive treatment plays a crucial role in preventing Chronic Renal Failure (CRF) and ESRD. The glomerulus and mesangial extracellular matrix are the principal
A. UNGAR +4 more
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[Renal aging: risk factors and nephroprotection].
Presse medicale (Paris, France : 1983), 2009Renal failure in the elderly is currently underestimated and presents a real challenge for the public health system. Kidney function must be routinely assessed by creatinine clearance, estimated with either the Cockcroft and Gault formula or the simplified MDRD formula, which appears especially appropriate for the elderly.
Maïté, Daroux +4 more
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