Results 71 to 80 of about 15,009 (224)
MXRA5 is a TGF-β1-regulated human protein with anti-inflammatory and anti-fibrotic properties [PDF]
, 2017 Current therapy for chronic kidney disease (CKD) is unsatisfactory because of an insufficient understanding of its pathogenesis. Matrix remodelling-associated protein 5 (MXRA5, adlican) is a human protein of unknown function with high kidney tissue ...
Carrasco, Susana +4 more
core +2 more sources
Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury
Experimental Physiology, EarlyView.Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley +1 more source
Ascorbic acid ameliorates renal injury in a murine model of contrast-induced nephropathy [PDF]
, 2017 BACKGROUND: Contrast induced nephropathy (CIN) is the commonest cause of iatrogenic renal injury and its incidence has increased with the advent of complex endovascular procedures.
A. Noorani +6 more
core +1 more source
Experimental Physiology, EarlyView.Abstract Renal arterial infusion of tempol (RAT) at the onset of Gram‐negative sepsis can prevent sepsis‐induced medullary tissue hypoxia and acute kidney injury (AKI). However, it is not known whether treatment with tempol at a clinically relevant time point of sepsis is similarly effective. Thus, we examined whether tempol can reverse renal medullary
Rachel Peiris +10 more
wiley +1 more source
SGLT2 inhibitors: control of glycemia and nephroprotection properties
Безопасность и риск фармакотерапии, 2018 Recently were appeared a fundamentally new insulin-independent approach to the treatment of type 2 diabetes - reduce blood glucose levels by inhibiting proteins co-transporters SGLT2 (sodium glucose transporter) in the proximal tubules of the kidneys ...
A. A. Volodin +3 more
doaj
Experimental Physiology, EarlyView.Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu +5 more
wiley +1 more source
Nephroprotective effect of the cardiotonic steroid ouabain [PDF]
, 2014 It has been shown that Na,K-ATPase (NKA) is a signal transducer. Our group described the anti-apoptotic effect of ouabain to the signaling function of NKA.
Burlaka, Ievgeniia
core +1 more source
Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.Manganese porphyrin catalyst enables green PhI(OAc)2 oxidation of lupeol in ethyl acetate, achieving 94% conversion and the formation of eight products, including selective C20 olefin transformations and one‐pot conversion of the isopropenyl group to carboxylic acids, all without the need of C3‐OH protection step.
Leila Renan Oliveira +5 more
wiley +1 more source
A Lanosteryl Triterpene (RA-3) Exhibits Antihyperuricemic and Nephroprotective Effects in Rats
Molecules, 2020 Considering the global health threat posed by kidney disease burden, a search for new nephroprotective drugs from our local flora could prove a powerful strategy to respond to this health threat.
Nomadlozi Blessings Hlophe +5 more
doaj +1 more source
The Anti-Inflammatory Effect of Erythropoietin and Melatonin on Renal Ischemia Reperfusion Injury in Male Rats [PDF]
, 2014 Purpose: Renal ischemia reperfusion (IR) is an important cause of renal dysfunction. It contributes to the development of acute renal failure (ARF). The purpose of this study was to investigate the anti-inflammatory effect of erythropoietin (EPO) and ...
Alireza Alihemmati +4 more
core +1 more source