Circulating neprilysin hypothesis
Circulating Neprilysin (sNEP) has emerged as a potential prognostic biomarker in heart failure (HF). In PARAGON-HF benefit of sacubitril/valsartan was only observed in patients with left ventricular ejection fraction (LVEF) ≤57%. We aimed to assess the prognostic value of sNEP in outpatients with HF and LVEF >57%, in comparison with patients with LVEF ≤
Lupón, Josep|| +10 more
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Sacubitril/valsartan fails to prevent doxorubicin-induced cognitive impairment and hippocampal oxidative, inflammatory, and apoptotic alterations in rats. [PDF]
Alresheedi MM, Aldubayan MA.
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PIONEER-HF: a new frontier in the role of neprilysin inhibition in the management of heart failure with reduced ejection fraction [PDF]
Kieran F. Docherty, John J.V. McMurray
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Angiotensin receptor-neprilysin inhibitors improve the outcome of lung cancer patients with hypertension undergoing immune checkpoint inhibitors treatment. [PDF]
Shang C +7 more
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Impact of prolonged utilization of neprilysin inhibition on the cognitive function of heart failure patients [PDF]
Niel Shah +7 more
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Angiotensin receptor-neprilysin inhibitor treatment in people with chronic obstructive pulmonary disease and heart failure. [PDF]
Hsu WH +10 more
europepmc +1 more source
Use of Angiotensin Receptor-Neprilysin Inhibitors (ARNis) in High-Output Heart Failure in a Young Hemodialysis Patient: Synergistic or Cumulative Effect? [PDF]
Silva SR +4 more
europepmc +1 more source
Investigating the binding potential of the Melissa officinalis oil against Alzheimer's targets by molecular docking and in vitro evaluations. [PDF]
Kolouei A, Barati M, Abbas-Mohammadi M.
europepmc +1 more source
Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models [PDF]
Mathew Blurton‐Jones +9 more
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