Results 181 to 190 of about 14,163 (275)

Neprilysin Inhibition in the Time of Precision Medicine ∗

JACC: Heart Failure, 2016
The recent results of the PARADIGM-HF trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) showing that the combination of the neprilysin (NEP) inhibitor sacubitril (sac) and the angiotensin receptor antagonist (ARB) valsartan (
openaire   +3 more sources

The efficacy of finerenone on hierarchical composite endpoint analysed using win statistics in patients with heart failure and mildly reduced or preserved ejection fraction: A prespecified analysis of FINEARTS‐HF

European Journal of Heart Failure, EarlyView.
Effect of finerenone on a hierarchical endpoint. CI, confidence interval; CV, cardiovascular; EF, ejection fraction; HF, heart failure. ABSTRACT Aims FINEARTS‐HF demonstrated the efficacy of finerenone in reducing total worsening heart failure (HF) events (first and recurrent) and cardiovascular death, compared to placebo, in patients with HF and ...
Toru Kondo, Pardeep S. Jhund, Alasdair D. Henderson, Brian L. Claggett, Akshay S. Desai, Meike Brinker, James Lay‐Flurrie, Patrick Schloemer, Prabhakar Viswanathan, Flaviana Amarante, Chern‐En Chiang, Gerasimos Filippatos, Carolyn S.P. Lam, Mark C. Petrie, Michele Senni, Morten Schou, Subodh Verma, Adriaan A. Voors, Dirk von Lewinski, Faiez Zannad, Bertram Pitt, Muthiah Vaduganathan, Scott D. Solomon, John J.V McMurray   +23 more
wiley   +1 more source

Integrated role of cardiac magnetic resonance and genetics in predicting left ventricular reverse remodelling in dilated and non‐dilated cardiomyopathy

European Journal of Heart Failure, EarlyView.
An integrated approach including late gadolinium enhancement data and genetics to predict left ventricular reverse remodelling in patients with dilated and non‐dilated left ventricular cardiomyopathy. DSP, desmoplakin; FLNC, filamin C; LMNA, lamin A/C; LVRR, left ventricular reverse remodelling; LGE, late gadolinium enhancement; MVA, major ventricular ...
Martina Setti, Manuela Iseppi, Job A.J. Verdonschot, Jacopo G. Rizzi, Alessia Paldino, Carola Pio Loco Detto Gava, Giulia Barbati, Matteo Dal Ferro, Max F.G.H.M. Venner, Anne G. Raafs, Marta Gigli, Davide Stolfo, Antonio De Luca, Giulia De Angelis, Teresa M. Capovilla, Sharon Graw, Flavio L. Ribichini, Matthew Taylor, Luisa Mestroni, Stephane R.B. Heymans, Gianfranco Sinagra, Marco Merlo   +21 more
wiley   +1 more source

Heart failure and obesity: Translational approaches and therapeutic perspectives. A scientific statement of the Heart Failure Association of the ESC

European Journal of Heart Failure, EarlyView.
Abstract Obesity and heart failure (HF) represent two growing pandemics. In the general population, obesity affects one in eight adults and is linked with an increased risk for HF. Obesity is even more common in patients with HF, where it complicates the diagnosis of HF and is linked with worse symptoms and impaired exercise capacity. Over the past few
Gianluigi Savarese, Gabriele G. Schiattarella, Felix Lindberg, Markus S. Anker, Antoni Bayes‐Genis, Magnus Bäck, Frieder Braunschweig, Chiara Bucciarelli‐Ducci, Javed Butler, Antonio Cannata, Federico Capone, Ovidiu Chioncel, Emilia D'Elia, Arantxa González, Gerasimos Filippatos, Nicolas Girerd, Jean‐Sébastien Hulot, Carolyn S.P. Lam, Lars H. Lund, Christoph Maack, Brenda Moura, Mark C. Petrie, Massimo Piepoli, Abdullah Shehab, Mehmet B. Yilmaz, Peter Seferovic, Carlo G. Tocchetti, Giuseppe M.C. Rosano, Marco Metra   +28 more
wiley   +1 more source

Safety and tolerability of sacubitril/valsartan in chronic heart failure and reduced ejection fraction: Results from the open‐label extension of the PARADIGM‐HF study

European Journal of Heart Failure, EarlyView.
Michele Senni, Pratap Paruchuru, Victor Shi, Michael Böhm   +3 more
wiley   +1 more source

Aetiological phenotypes of atrial and ventricular secondary tricuspid regurgitation and their prognostic implications: insights from the CARE‐TR registry

European Journal of Heart Failure, EarlyView.
Aetiological phenotypes of secondary tricuspid regurgitation. AF, atrial fibrillation; HFpE, heart failure with preserved ejection fraction; CARE‐TR, Consecutive pAtients with seveRE Tricuspid Regurgitation evaluated in Heart Failure and Valve Clinics; HF, heart failure; HFmrEF, heart failure with mildly reduced ejection fraction; HFrEF, heart failure ...
Laura Lupi, Elena Antonioli, Angelica Praderio, Alessandro Villaschi, Elisa Soranzo, Nicola Saccani, Kamil Stankowski, Daniele Cocianni, Beniamino Pagliaro, Valeria Magni, Marco Loffi, Daniela Tomasoni, Matteo Pagnesi, Antonio Mangieri, Davide Stolfo, Gianfranco Sinagra, Marianna Adamo, Marco Metra   +17 more
wiley   +1 more source

Angioedema following venipuncture in a patient on angiotensin‐converting enzyme inhibitor and dipeptidyl peptidase‐IV inhibitor therapy: A case report

JEADV Clinical Practice, EarlyView.
Abstract Acquired angioedema (AAE) is a rare, potentially life‐threatening condition, primarily induced by medications, with attacks typically triggered by major trauma. We report a rare case of AAE triggered locally by minor trauma—a forearm venipuncture—in a 77‐year‐old male taking ramipril and sitagliptin.
Adrien Bénic, Adrien Boyard, Alexan Pogossian, Laurent Misery, Anne‐Marie Roguedas‐Contios   +4 more
wiley   +1 more source

Role of ACE, ACE2 and Neprilysin in the Kidney

, 2007
From the initial description of renin activity over a century ago, ongoing study of the renin-angiotensin-aldosterone system (RAAS) continues to yield novel findings that redefine the functional nature of this system, as well as reveal the complexity of the interplay among the various RAAS components.
openaire   +2 more sources

The role of gut microbiota‐derived metabolites in neuroinflammation

Neuroprotection, EarlyView.
Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
wiley   +1 more source

Physical activity and beta-amyloid pathology in Alzheimer's disease [PDF]

, 2017
Alzheimer's disease (AD) is the most common type of dementia worldwide. Since curative treatment has not been established for AD yet and due to heavy financial and psychological costs of patients’ care, special attention has been paid to preventive ...
Baghaiee, Behrouz, Ebrahimi, Khadije, Hosseini, Seyed Hojjat, Majdi, Alireza, Sadigh-Eteghad, Saeed   +4 more
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