Results 31 to 40 of about 3,812 (144)

Detection of Novichok and V-Group Nerve Agents by Chemosensors Containing Nile Blue Chromophore

Chemosensors
This paper presents the results of experiments aiming for the detection and differentiation of selected nerve agents of the Novichok and V-group using simple strip detectors containing colourimetric indicator, specifically chemosensor Nile Blue A ...
Martin Urban, Tomáš Dropa, Markéta Zelenková, Michal Dymák, Vladimír Pitschmann   +4 more
doaj   +1 more source

Comparison of Binding Affinities of Water-Soluble Calixarenes with the Organophosphorus Nerve Agent Soman (GD) and Commonly-Used Nerve Agent Simulants

Molecules, 2018
The formation of inclusion complexes of the water-soluble p-sulfonatocalix[n]arenes, where n = 4 or 6, with the Chemical Warfare Agent (CWA) GD, or Soman, and commonly used dialkyl methylphosphonate simulants has been studied by experimental solution NMR
Jayne A. Ede, Peter J. Cragg, Mark R. Sambrook   +2 more
doaj   +1 more source

Enaminone Modulators of Extrasynaptic α4β3δ γ-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning

Frontiers in Pharmacology, 2019
Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABAARs) that rapidly internalize during status epilepticus (SE ...
Timothy B. C. Johnstone, Hilary S. McCarren, Jay Spampanato, F. Edward Dudek, John H. McDonough, Derk Hogenkamp, Kelvin W. Gee   +6 more
doaj   +1 more source

Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase

Communications Biology, 2021
Amitai et al. identified 4 potential small molecule antidotes toward nerve agents poisoning by high-throughput-screening of over 150,000 compounds. Unique non-quaternary oximes represent new potential antidotes for future development as they detoxified ...
Gabriel Amitai, Alexander Plotnikov, Shira Chapman, Shlomi Lazar, Rellie Gez, Dan Loewenthal, Khriesto A. Shurrush, Galit Cohen, Leonardo J. Solmesky, Haim Barr, Alan J. Russell   +10 more
doaj   +1 more source

Nerve agents: A clear and present danger to mankind [PDF]

Scripta Medica, 2019
This editorial is written on the occasion of the 25th anniversary of the infamous sarin and VX terrorist attacks in Japan, in order to increase the awareness of the potential terrorist use of nerve agents and to urge the preparedness to cope with its ...
Stojiljković Miloš P.
doaj  

Development of organophosphate hydrolase activity in a bacterial homolog of human cholinesterase

Frontiers in Chemistry, 2014
We applied a combination of rational design and directed evolution (DE) to Bacillus subtilis p-nitrobenzyl esterase (pNBE) with the goal of enhancing organophosphorus acid anhydride hydrolase (OPAAH) activity.
Patricia Marie Legler, Susanne eBoisvert, Jaimee R Compton, Charles B. Millard   +3 more
doaj   +1 more source

The value of 3D high-resolution IR-prepared fast spoiled gradient-recalled MRI in the diagnosis of meningeal carcinomatosis involving the cranial nerves

BMC Medical Imaging, 2023
Purpose The purpose of this study was to investigate the clinical utility of three-dimension (3D) high-resolution inversion recovery (IR)-prepared fast spoiled gradient-recalled (SPGR) magnetic resonance imaging (MRI) in the diagnosis of cranial nerve ...
Lulu Xuan, Jiafu Huang, Huikang Yin, Zehua Lu, Xiaoliang Yang, Liyue Yang, Chengjun Geng   +6 more
doaj   +1 more source

Analyzing the Salisbury Incident under International Law

Public and Private International Law Bulletin, 2022
On March 04, 2018, Sergei Skripal (former Russian spy) and his daughter, Yulia Skripal, were found unconscious in Salisbury in the United Kingdom. An investigation by the authorities found that Skripal and his daughter had been exposed to Novichok nerve ...
Selman Özdan, Büşra Beydüz
doaj   +1 more source

Biphasic response of human iPSC-derived neural network activity following exposure to a sarin-surrogate nerve agent

Frontiers in Cellular Neuroscience
Organophosphorus nerve agents (OPNA) are hazardous environmental exposures to the civilian population and have been historically weaponized as chemical warfare agents (CWA). OPNA exposure can lead to several neurological, sensory, and motor symptoms that
Chandrakumar Bogguri, Vivek Kurien George, Beheshta Amiri, Alexander Ladd, Nicholas R. Hum, Aimy Sebastian, Heather A. Enright, Carlos A. Valdez, T. Nathan Mundhenk, Jose Cadena, Doris Lam   +10 more
doaj   +1 more source

Antiseizure and Neuroprotective Efficacy of Midazolam in Comparison with Tezampanel (LY293558) against Soman-Induced Status Epilepticus

Toxics, 2022
Acute exposure to nerve agents induces status epilepticus (SE), which can cause death or long-term brain damage. Diazepam is approved by the FDA for the treatment of nerve agent-induced SE, and midazolam (MDZ) is currently under consideration to replace ...
Taiza H. Figueiredo, Vassiliki Aroniadou-Anderjaska, Volodymyr I. Pidoplichko, James P. Apland, Maria F. M. Braga   +4 more
doaj   +1 more source